N-acetylcysteine improves group B streptococcus clearance in a rat model of chronic ethanol ingestion

Alcoholism: Clinical and Experimental Research

Volumn 33, Issue 7, 2009, Pages 1197-1201

  Tang, Sonja M ^b   Gabelaia, Levan ^b   Gauthier, Theresa W ^b   Brown, Lou Ann S ^a  

^a Department of Pediatrics ^*  (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute Lung Injury; Alcohol Abuse; Glutathione; Oxidative Stress; Sepsis

Indexed keywords

ACETYLCYSTEINE;

ACUTE LUNG INJURY; ALCOHOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; BACTERIUM IDENTIFICATION; CHRONIC DISEASE; CLEARANCE; CLINICAL ASSESSMENT; COLONY FORMING UNIT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE COURSE; DISEASE PREDISPOSITION; EXPERIMENTAL MODEL; IN VIVO STUDY; INFECTION RISK; LIVER; LUNG; LUNG INFECTION; LUNG LAVAGE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SPLEEN; STREPTOCOCCUS AGALACTIAE;

ACETYLCYSTEINE; ALCOHOLISM; ANIMALS; DISEASE MODELS, ANIMAL; ETHANOL; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; STREPTOCOCCUS AGALACTIAE;

BACTERIA (MICROORGANISMS); RATTUS; STREPTOCOCCUS SP. 'GROUP B';

EID: 67650685608     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2009.00943.x     Document Type: Article

References (31)

1. Auerbach-Rubin F, Ottolenghi-Nightingale E (1971) Effect of ethanol on the clearance of airborne pneumococci and the rate of pneumococcal transformations in the lung. Infect Immun 3 : 688 693.
2. Bagasra O, Howeedy A, Kajdacsy-Balla A (1988) Macrophage function in chronic experimental alcoholism. I. Modulation of surface receptors and phagocytosis. Immunology 65 : 405 409. (Pubitemid 18274909)
3. Blancas D, Santin M, Olmo M, Alcaide F, Carratala J, Gudiol F (2004) Group B streptococcal disease in nonpregnant adults: incidence, clinical characteristics, and outcome. Eur J Clin Microbiol Infect Dis 23 : 168 173. (Pubitemid 38471421)
4. Boé DM, Nelson S, Zhang P, Bagby GJ (2001) Acute ethanol intoxication suppresses lung chemokine production following infection with Streptococcus pneumoniae. J Infect Dis 184 : 1134 1142. (Pubitemid 33010466)
5. Brown LA, Harris FL, Ping XD, Gauthier TW (2004) Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability? Alcohol 33 : 191 197. (Pubitemid 41123661)
6. Brown LA, Ping XD, Harris FL, Gauthier TW (2007) Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat. Am J Physiol Lung Cell Mol Physiol 292 : L824 L832.
7. Burnham EL, Brown LA, Halls L, Moss M (2003) Effects of chronic alcohol abuse on alveolar epithelial barrier function and glutathione homeostasis. Alcohol Clin Exp Res 27 : 1167 1172. (Pubitemid 36890395)
8. Burnham EL, Moss M, Harris F, Brown LA (2004) Elevated plasma and lung endothelial selectin levels in patients with acute respiratory distress syndrome and a history of chronic alcohol abuse. Crit Care Med 32 : 675 679. (Pubitemid 38340062)
9. Fernandez-Sola J, Junque A, Estruch R, Monforte R, Torres A, Urbano-Marquez A (1995) High alcohol intake as a risk and prognostic factor for community-acquired pneumonia. Arch Intern Med 155 : 1649 1654.
10. Gamble L, Mason C, Nelson S (2006) The effects of alcohol on immunity and bacterial infection in the lung. Médecine et maladies infectieuses 36 : 72 77. (Pubitemid 43294627)
11. Green GM, Kass EH (1964) The role of the alveolar macrophage in the clearance of bacteria from the lung. J Exp Med 119 : 167 176.
12. Guidot DM, Modelska K, Lois M, Jain L, Moss IM, Pittet JF, Brown LA (2000) Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats. Am J Physiol Lung Cell Mol Physiol 279 : L127 L135.
13. Guidot D, Moss M, Holguin F, Lois M, Brown L (1999) Ethanol ingestion impairs alveolar epithelial glutathione homeostasis and function, and predisposes to endotoxin-mediated acute lung injury. Chest 116 (Suppl 1 82S. (Pubitemid 29340221)
14. Happel K, Bagby G, Nelson S (2004) Host defense and bacterial pneumonia. Semin Respir Crit Care Med 25 : 43 52. (Pubitemid 38296158)
15. Happel KI, Nelson S (2005) Alcohol, immunosuppression, and the lung. Proc Am Thorac Soc 2 : 428 432. (Pubitemid 43128038)
16. Holguin F, Moss IM, Brown L, Guidot D (1998) Chronic ethanol ingestion impairs alveolar type II cell glutathione homeostasis and function and predisposes to endotoxin-mediated acute edematous lung injury in rats. J Clin Invest 101 : 761 768. (Pubitemid 28096072)
17. Huang P-Y, Lee M-H, Yang C-C, Leu H-S (2006) Group B streptococcal bacteremia in non-pregnant adults. J Microbiol Immunol Infect 39 : 237 241. (Pubitemid 44385742)
18. Jong GM, Hsiue TR, Chen CR, Chang HY, Chen CW (1995) Rapidly fatal outcome of bacteremic Klebsiella pneumoniae pneumonia in alcoholics. Chest 107 : 214 217.
19. Joshi PC, Guidot DM (2007) The alcoholic lung: epidemiology, pathophysiology, and potential therapies. Am J Physiol Lung Cell Mol Physiol 292 : L813 L823.
20. Moss M, Guidot DM, Wong-Lambertina M, Ten Hoor T, Perez RL, Brown LA (2000) The effects of chronic alcohol abuse on pulmonary glutathione homeostasis. Am J Respir Crit Care Med 161 (2 Pt 1 414 419. (Pubitemid 30129446)
21. Moss M, Parsons P, Steinberg K, Hudson L, Guidot D, Burnham E, Eaton S, Cotsonis G (2003) Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med 31 : 869 877. (Pubitemid 36379598)
22. Moss M, Steinberg KP, Guidot DM, Duhon GF, Treece P, Wolken R, Hudson LD, Parsons PE (1999) The effect of chronic alcohol abuse on the incidence of ARDS and the severity of the multiple organ dysfunction syndrome in adults with septic shock: an interim and multivariate analysis. Chest 116 : 97S 98S. (Pubitemid 29340235)
23. Mufti S, Prabhala R, Moriguchi S, Sipes I, Watson R (1988) Functional and numerical alterations induced by ethanol in the cellular immune system. Immunopharmacology 15 : 85 94. (Pubitemid 18102468)
24. Perlino CA, Rimland D (1985) Alcoholism, leukopenia, and pneumococcal sepsis. Am Rev Respir Dis 132 : 757 760. (Pubitemid 16247734)
25. Ping XD, Harris FL, Brown LA, Gauthier TW (2007) In vivo dysfunction of the term alveolar macrophage after in utero ethanol exposure. Alcohol Clin Exp Res 31 : 308 316. (Pubitemid 46156867)
26. Ruiz M, Ewig S, Torres A, Arancibia F, Marco F, Mensa J, Sanchez M, Martinez JA (1999) Severe community-acquired pneumonia. risk factors and follow-up epidemiology. Am J Respir Crit Care Med 160 : 923 929. (Pubitemid 29442032)
27. Sisson JH, Wyatt TA, Guidot DM, Bagby GJ, Helander A, Tonnesen H, Spies CD (2005) Bench to bedside: mechanisms and consequences of alcohol-altered host defenses. Alcohol Clin Exp Res 29 : 1090 1097. (Pubitemid 40934214)
28. Thomsen JL, Sogaard P (1999) Bacteria in lung tissue from an autopsy population of alcoholics. Forensic Sci Int 99 : 53 59. (Pubitemid 29010325)
29. Velasquez A, Bechara RI, Lewis JF, Malloy J, McCaig L, Brown LA, Guidot DM (2002) Glutathione replacement preserves the functional surfactant phospholipid pool size and decreases sepsis-mediated lung dysfunction in ethanol-fed rats. Alcohol Clin Exp Res 26 : 1245 1251. (Pubitemid 34913212)
30. Wyatt TA, Sisson JH (2001) Chronic ethanol downregulates PKA activation and ciliary beating in bovine bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 281 : L575 L581.
31. Yeh MY, Burnham EL, Moss M, Brown LA (2007) Chronic alcoholism alters systemic and pulmonary glutathione redox status. Am J Respir Crit Care Med 176 : 270 276. (Pubitemid 47195877)