Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated

Journal of Cell Science

Volumn 126, Issue 21, 2013, Pages 4985-4994

  Fleck, Oliver ^a,b   Vejrup Hansen, Rasmus ^a,c   Watson, Adam ^d   Carr, Antony M ^d   Nielsen, Olaf ^a   Holmberg, Christian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b BANGOR UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Checkpoint kinase; Ddb1; Genome instability; Ribonucleotide reductase; Spd1

Indexed keywords

CHECKPOINT KINASE 2; DEOXYRIBONUCLEOTIDE; MUTANT PROTEIN; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE CDC22; SPD1 PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA REPLICATION; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME SUBUNIT; FUNGAL GENOME; GENE DELETION; GENE POOL; GENOMIC INSTABILITY; MUTATION RATE; NEGATIVE FEEDBACK; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TARGETING; SCHIZOSACCHAROMYCES;

CHECKPOINT KINASE; DDB1; GENOME INSTABILITY; RIBONUCLEOTIDE REDUCTASE; SPD1;

CELL CYCLE PROTEINS; DEOXYRIBONUCLEOTIDES; DNA-BINDING PROTEINS; GENOME, FUNGAL; GENOMIC INSTABILITY; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EID: 84887575673     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.132837     Document Type: Article

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