Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost

International Journal of Radiation Oncology Biology Physics

Volumn 66, Issue 5, 2006, Pages 1335-1338

  Vaidya, Jayant S ^a   Baum, Michael ^b   Tobias, Jeffrey S ^b   Massarut, Samuele ^d   Wenz, Frederik ^c   Murphy, Olive ^b   Hilaris, Basil ^f   Houghton, Joan ^b   Saunders, Christobel ^e   Corica, Tammy ^e   Roncadin, Mario ^d   Kraus Tiefenbacher, Uta ^c   Melchaert, Frank ^c   Keshtgar, Mohammed ^b   Sainsbury, Richard ^b   Douek, Michael ^b   Harrison, Elly ^b   Thompson, Alastair ^a   Joseph, David ^e  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^d UNIVERSITY OF MANNHEIM   (Germany)

^e SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^f NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Boost; Breast cancer; Breast conserving surgery; Recurrence rate; Targeted intraoperative radiotherapy (TARGIT)

Indexed keywords

MAMMOGRAPHY; ONCOLOGY; PATIENT MONITORING; TUMORS;

BOOST; BREAST-CONSERVING SURGERY; RECURRENCE RATE; TARGETED INTRAOPERATIVE RADIOTHERAPY (TARGIT);

RADIOTHERAPY;

ADULT; AGED; ARTICLE; AXILLARY LYMPH NODE; BREAST CARCINOMA; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RISK; CANCER SURGERY; CONTROLLED STUDY; EXTERNAL BEAM RADIOTHERAPY; FOLLOW UP; HIGH RISK POPULATION; HUMAN; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RADIATION BEAM;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; COMBINED MODALITY THERAPY; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTRAOPERATIVE PERIOD; MASTECTOMY, SEGMENTAL; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PILOT PROJECTS; RADIOTHERAPY; RADIOTHERAPY DOSAGE;

EID: 33751174515     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.07.1378     Document Type: Article

References (16)

1. Vaidya J.S., Vyas J.J., Mittra I., et al. Multicentricity and its influence on conservative breast cancer treatment strategy. Hong Kong Int Cancer Congress (1995) November; Abstract 44.4.
2. Machtay M., Lanciano R., Hoffman J., et al. Inaccuracies in using the lumpectomy scar for planning electron boosts in primary breast carcinoma. Int J Radiat Oncol Biol Phys 30 (1994) 43-48
3. Sedlmayer F., Rahim H.B., Kogelnik H.D., et al. Quality assurance in breast cancer brachytherapy: Geographic miss in the interstitial boost treatment of the tumor bed. Int J Radiat Oncol Biol Phys 34 (1996) 1133-1139
4. Benda R.K., Yasuda G., Sethi A., et al. Breast boost: Are we missing the target?. Cancer 97 (2003) 905-909
5. Vaidya J.S., Baum M., Tobias J.S., et al. Targeted intraoperative radiotherapy (TARGIT): An innovative method of treatment for early breast cancer. Ann Oncol 12 (2001) 1075-1080
6. Vaidya J.S., Baum M., Tobias J.S., et al. The novel technique of delivering targeted intraoperative radiotherapy (TARGIT) for early breast cancer. Eur J Surg Oncol 28 (2002) 447-454
7. Vaidya J.S., Baum M., Tobias J.S., et al. Targeted Intraoperative Radiothearpy (TARGIT)-trial protocol. Lancet (1999). http://www.thelancet.com/journals/lancet/misc/protocol/99PRT-47 online. Available at: http://www.thelancet.com/journals/lancet/misc/protocol/99PRT-47.
8. Vaidya J.S., Joseph D., Hilaris B.S., et al. Targeted intraoperative radiotherapy for breast cancer: An international trial. Abstract Book of ESTRO-21 (Prague) 21 (2002) 135
9. Kraus-Tiefenbacher U., Scheda A., Steil V., et al. Intraoperative radiotherapy (IORT) for breast cancer using the Intrabeam system. Tumori 91 (2005) 339-345
10. Joseph D.J., Bydder S., Jackson L.R., et al. Prospective trial of intraoperative radiation treatment for breast cancer. ANZ J Surg 74 (2004) 1043-1048
11. Vaidya J.S. A novel approach for local treatment of early breast cancer (2002), University of London 1-242 PhD thesis, May
12. Vaidya J.S., Wilson A.J., Houghton J., et al. Cosmetic outcome after targeted intraoperative radiotherapy (TARGIT) for early breast caner. Breast Cancer Res Treatment 82 (2003) 1039
13. Tobias J.S., Vaidya J.S., Keshtgar M., et al. Reducing radiotherapy dose in early breast cancer: The concept of conformal intraoperative brachytherapy. Br J Radiol 77 (2004) 279-284
14. Massarut S., Baldassarre G., Belletti B., et al. Intraoperative radiotherapy impairs breast cancer cell motility by surgical wound fluid. [Abstract]. J Clin Oncol 24 18 suppl (2006) 10611
15. Enderling H., Anderson A.R., Chaplain M.A., et al. Mathematical modelling of radiotherapy strategies for early breast cancer. J Theor Biol 241 (2006) 158-171
16. Bartelink H., Horiot J.C., Poortmans P., et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 345 (2001) 1378-1387