Erratum: P16INK4A Represses the paracrine tumor-promoting effects of breast stromal fibroblasts (Oncogene (2013) 32 (2356-2364) DOI: 10.1038/onc.2012.270);P16 INK4A Represses the paracrine tumor-promoting effects of breast stromal fibroblasts

Oncogene

Volumn 32, Issue 18, 2013, Pages 2356-2364

  Al Ansari, M M ^a   Hendrayani, S F ^a   Shehata, A I ^b   Aboussekhra, A ^a  

^a Department of Molecular Oncology ^*  (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

AUF1; breast cancer; cell nonautonomous tumor suppression; p16INK4A; stromal fibroblasts

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLOOXYGENASE 2; GELATINASE A; GELATINASE B; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; MESSENGER RNA; PROTEIN KINASE B; SMALL INTERFERING RNA; STROMAL CELL DERIVED FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST; BREAST CANCER; CANCER ASSOCIATED FIBROBLAST; CANCER CELL; CANCER GROWTH; CANCER TISSUE; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FEMALE; FIBROBLAST; GROWTH RATE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; STROMA; TUMOR PROMOTION; TUMOR XENOGRAFT; TURNOVER TIME; UPREGULATION;

MUS;

EID: 84877585372     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.58     Document Type: Erratum

References (41)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. Ca Cancer J Clin 2011; 61: 69-90.
2. Shimoda M, Mellody KT, Orimo A. Carcinoma-associated fibroblasts are a ratelimiting determinant for tumour progression. Semin Cell Dev Biol 2009; 21: 19-25.
3. Franco OE, Shaw AK, Strand DW, Hayward SW. Cancer associated fibroblasts in cancer pathogenesis. Semin Cell Dev Biol 2009; 21: 33-39.
4. Dong-Le Bourhis X, Berthois Y, Millot G, Degeorges A, Sylvi M, Martin PM et al. Effect of stromal and epithelial cells derived from normal and tumorous breast tissue on the proliferation of human breast cancer cell lines in co-culture. Int J Cancer 1997; 71: 42-48.
5. Kim JB, Stein R, O'Hare MJ. Tumour-stromal interactions in breast cancer: the role of stroma in tumourigenesis. Tumour Biol 2005; 26: 173-185.
6. van Roozendaal KE, Klijn JG, van Ooijen B, Claassen C, Eggermont AM, Henzen-Logmans SC et al. Differential regulation of breast tumor cell proliferation by stromal fibroblasts of various breast tissue sources. Int J Cancer 1996; 65: 120-125.
7. Noel A, De Pauw-Gillet MC, Purnell G, Nusgens B, Lapiere CM, Foidart JM. Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts. Br J Cancer 1993; 68: 909-915.
8. Camps JL, Chang SM, Hsu TC, Freeman MR, Hong SJ, Zhau HE et al. Fibroblastmediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci USA 1990; 87: 75-79.
9. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005; 121: 335-348.
10. Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006; 6: 392-401.
11. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366: 704-707.
12. Ohtani N, Yamakoshi K, Takahashi A, Hara E. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest 2004; 51: 146-153.
13. Wang W, Martindale JL, Yang X, Chrest FJ, Gorospe M. Increased stability of the p16 mRNA with replicative senescence. EMBO Rep 2005; 6: 158-164.
14. Al-Mohanna MA, Al-Khalaf HH, Al-Yousef N, Aboussekhra A. The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light. Nucleic Acids Res 2007; 35: 223-233.
15. Mitra J, Dai CY, Somasundaram K, El-Deiry WS, Satyamoorthy K, Herlyn M et al. Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). Mol Cell Biol 1999; 19: 3916-3928.
16. Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen JV et al. RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. Mol Cell 2009; 35: 511-522.
17. Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009; 119: 1429-1437doi:1410.1172/JCI36183.
18. Arendt LM, Rudnick JA, Keller PJ, Kuperwasser C. Stroma in breast development and disease. Semin Cell Dev Biol 2009; 21: 11-18.
19. Hu M, Polyak K. Molecular characterisation of the tumour microenvironment in breast cancer. Eur J Cancer 2008; 44: 2760-2765.
20. Matros E, Wang ZC, Lodeiro G, Miron A, Iglehart JD, Richardson AL. BRCA1 promoter methylation in sporadic breast tumors: relationship to gene expression profiles. Breast Cancer Res Treat 2005; 91: 179-186.
21. Mazan-Mamczarz K, Kuwano Y, Zhan M, White EJ, Martindale JL, Lal A et al. Identification of a signature motif in target mRNAs of RNA-binding protein AUF1. Nucleic Acids Res 2009; 37: 204-214.
22. Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H et al. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 2004; 6: 17-32.
23. Sadlonova A, Bowe DB, Novak Z, Mukherjee S, Duncan VE, Page GP et al. Identification of molecular distinctions between normal breast-associated fibroblasts and breast cancer-associated fibroblasts. Cancer Microenviron 2009; 2: 9-21.
24. Bauer M, Su G, Casper C, He R, Rehrauer W, Friedl A. Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast. Oncogene 2010; 29: 1732-1740.
25. Singer CF, Gschwantler-Kaulich D, Fink-Retter A, Haas C, Hudelist G, Czerwenka K et al. Differential gene expression profile in breast cancer-derived stromal fibroblasts. Breast Cancer Res Treat 2008; 110: 273-281.
26. Moskovits N, Kalinkovich A, Bar J, Lapidot T, Oren M. p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts. Cancer Res 2006; 66: 10671-10676.
27. Atienza JM, Yu N, Kirstein SL, Xi B, Wang X, Xu X et al. Dynamic and label-free cellbased assays using the real-time cell electronic sensing system. Assay Drug Dev Technol 2006; 4: 597-607.
28. Chintala SK, Fueyo J, Gomez-Manzano C, Venkaiah B, Bjerkvig R, Yung WK et al. Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro. Oncogene 1997; 15: 2049-2057.
29. Romagosa C, Simonetti S, Lopez-Vicente L, Mazo A, Lleonart ME, Castellvi J et al. p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors. Oncogene 2011; 30: 2087-2097.
30. Witkiewicz AK, Knudsen KE, Dicker AP, Knudsen ES. The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments. Cell Cycle 2011; 10: 2497-2503.
31. Souza-Rodrigues E, Estanyol JM, Friedrich-Heineken E, Olmedo E, Vera J, Canela N et al. Proteomic analysis of p16ink4a-binding proteins. Proteomics 2007; 7: 4102-4111.
32. Sun P, Nallar SC, Raha A, Kalakonda S, Velalar CN, Reddy SP et al. GRIM-19 and p16(INK4a) synergistically regulate cell cycle progression and E2F1-responsive gene expression. J Biol Chem 2010; 285: 27545-27552.
33. Gao MQ, Kim BG, Kang S, Choi YP, Park H, Kang KS et al. Stromal fibroblasts from the interface zone of human breast carcinomas induce an epithelialmesenchymal transition-like state in breast cancer cells in vitro. J Cell Sci 2010; 123: 3507-3514.
34. Hu M, Peluffo G, Chen H, Gelman R, Schnitt S, Polyak K. Role of COX-2 in epithelialstromal cell interactions and progression of ductal carcinoma in situ of the breast. Proc Natl Acad Sci USA 2009; 106: 3372-3377.
35. Aboussekhra A. Role of cancer-associated fibroblasts in breast cancer development and prognosis. Int J Develop Biol 2011; 55: 841-849.
36. Kiaris H, Chatzistamou I, Trimis G, Frangou-Plemmenou M, Pafiti-Kondi A, Kalofoutis A. Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis. Cancer Res 2005; 65: 1627-1630.
37. Trimis G, Chatzistamou I, Politi K, Kiaris H, Papavassiliou AG. Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors. Hum Mol Genet 2008; 17: 3596-3600.
38. Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N et al. Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature 2009; 461: 1084-1091.
39. Trimmer C, Sotgia F, Whitaker-Menezes D, Balliet RM, Eaton G, Martinez-Outschoorn UE et al. Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts. Cancer Biol Ther 2011; 11: 383-394.
40. Hawsawi NM, Ghebeh H, Hendrayani SF, Tulbah A, Al-Eid M, Al-Tweigeri T et al. Breast carcinoma-associated fibroblasts and their counterparts display neoplasticspecific changes. Cancer Res 2008; 68: 2717-2725.
41. Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ et al. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 2001; 413: 86-91.