The surgical margin status after breast-conserving surgery: Discussion of an open issue

Breast Cancer Research and Treatment

Volumn 113, Issue 2, 2009, Pages 397-402

  Luini, Alberto ^a,b   Rososchansky, Joel ^a,c   Gatti, Giovanna ^a   Zurrida, Stefano ^a   Caldarella, Pietro ^a   Viale, Giuseppe ^a,d   Rosali Dos Santos, Gabriela ^a   Frasson, Antonio ^e  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c Unimast Clinic Mastology and Plastic Surgery   (Brazil)

^d UNIVERSITY OF MILAN   (Italy)

^e PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Breast carcinoma; Local relapse; Surgical margins

Indexed keywords

ARTICLE; BREAST CARCINOMA; BREAST SURGERY; CANCER CONTROL; CANCER RELAPSE; CANCER SURGERY; HUMAN; INVASIVE CARCINOMA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; SURGICAL APPROACH; SURGICAL TECHNIQUE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA; CARCINOMA, INTRADUCTAL, NONINFILTRATING; COMBINED MODALITY THERAPY; FEMALE; HUMANS; MASTECTOMY, SEGMENTAL; NEOPLASM RECURRENCE, LOCAL; NEOPLASM, RESIDUAL; RADIOTHERAPY, ADJUVANT; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REOPERATION; RETROSPECTIVE STUDIES; RISK; TREATMENT FAILURE;

EID: 58149231348     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-008-9929-0     Document Type: Article

References (51)

1. B Fisher J Dignam N Wolmark 1998 Lumpectomy and radiation therapy for the treatment of intraductal breast cancer. Findings from National Surgical Adjuvant Breast and Bowel Project B-17 J Clin Oncol 16 441 452
2. ER Fisher J Dignam E Tan-Chiu 1999 Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP): eight-year update of protocol B-17 Cancer 86 429 438
3. ER Fisher J Costantino B Fisher 1995 Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) protocol B-17 Cancer 75 1310 1319
4. T Ikeda F Akiyama M Hiraoka 1999 Surgical margin status as a cause of local failure after breast conserving therapy Breast Cancer 6 93 97
5. I Gage SJ Schnitt AJ Nixon 1996 Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy Cancer 9 1921 1928
6. MS Anscher P Jones LR Prosnitz 1993 Local failure and margin status in early stage breast carcinoma treated with conservation surgery and radiation therapy Ann Surg 218 22 28
7. L Tafra J Guenter A Giuliano 1993 Planeed segmentectomy: a necessity for breast carcinoma Arch Surg 128 1014 1020
8. CC Park M Mitsumori A Nixon 2000 Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence J Clin Oncol 8 1668 1675
9. G Freedman B Fowble A Hanlon 1999 Patients with early stage invasive cancer with close or positive margins treated with conservative surgery and radiation have an increased risk of breast recurrence that is delayed by adjuvant systemic therapy Int J Radiat Oncol Biol Phys 44 1005 1015
10. DE Wazer T DiPetrillo RK Schmidt-Ulrich L Weld 1992 Factors influencing cosmetic outcome and complication risk after conservative surgery and radiotherapy for early stage breast carcinoma J Clin Oncol 10 356 363
11. MC Smitt KW Nowels MJ Zdeblick 1995 The importance of the lumpectomy surgical margin status in long-term results of breast conservation Cancer 76 259 267
12. MZ Papa D Zippel M Koller 1999 Positive margins of breast biopsy : is reexcision always necessary? J Surg Oncol 70 167 171
13. ME Peterson DJ Schultz C Reynolds 1999 Outcome in breast cancer patients relative to margin status after treatment with breast-conserving surgery and radiation therapy. The University of Pennsylvania experience Int J Radiat Oncol Biol Phys 43 1029 1035
14. SJ Schnitt A Abner R Gelman 1994 The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast-conserving surgery and radiation therapy Cancer 74 1746 1751
15. TP Pittinger NC Maronian CA Poulter 1994 Importance of margin status in outcome of breast-conserving surgery for carcinoma Surgery 116 605 609
16. FA Vicini LL Kestin NS Goldstein 2001 Relationship between excision volume, margin status, and tumor size with the development of local recurrence in patients with ductal carcinoma in situ treated with breast-conserving therapy J Surg Oncol 76 245 254
17. DE Wazer RK Schmidt- Ullrich CH Schmid 1997 The value of breast lumpectomy margin assessment as a predictor of residual tumor burden Int J Radiat Oncol Biol Phys 38 291 299
18. CC Park M Mitsumori A Reacht 1998 The relationship between pathologic margin status and outcome after breast-conserving therapy (Abstr) Int J Radiat Oncol Biol Phys 42 125
19. LJ Solin BL Fowble DJ Schultz 1991 The significance of the pathology margins of the tumor excision on the outcome of patients treated with definitive irradiation for early stage breast cancer Int J Radiat Oncol Biol Phys 21 279 287
20. AC Neuschatz T DiPetrillo M Steinhoff 2002 The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast Cancer 94 1917 1924
21. GP Swanson K Rynearson R Symmonds 2002 Significance of margins of excision on breast cancer recurrence Am J Clin Oncol (CCT) 5 438 441
22. ER Sauter JP Hoffman FD Ottery 1994 Is frozen section analysis of reexcision lumpectomy margins worthwhile? Margin analysis in breast reexcisions Cancer 73 2607 2612
23. DE Wazer RK Schmidt-Ulrich R Ruthazer 1998 Factors determining outcome for breast-conserving irradiation with margin-directed dose escalation to the tumor bed Int J Radiat Oncol Biol Phys 40 851 858
24. B Spivack MM Khanna L Tafra 1994 Margins status and local recurrence after breast conserving surgery Arch Surg 129 952 956
25. N Sneige Mc Neese EN Atkinson 1995 Ductal carcinoma in situ treated with lumpectomy and irradiation: histopathological analysis of 49 specimens with emphasis on risk factors and long term results Hum Pathol 26 642 649
26. SJ DiBiase LT Komarnicky DE Heron 2002 Influence of radiation dose on positive surgical margins in women undergoing breast conservation therapy Int J Radiat Oncol Biol Phys 3 680 686
27. PI Tartter J Kaplan I Bleiweiss 2000 Lumpectomy margins, reexcision, and local recurrence of breast cancer Am J Surg 179 81 85
28. MJ Silverstein JR Waisman P Gamagami 1990 Intraductal carcinoma of the breast (208 cases): clinical factors influencing treatment choice Cancer 66 102 108
29. LJ Solin J Kurtz A Fourquet 1996 Fifteen-year results of breast-conserving surgery and definitive breast irradiation for the treatment of ductal carcinoma in situ of the breast J Clin Oncol 14 754 763
30. MJ Silverstein BF Cohlan ED Gierson 1992 Duct carcinoma in situ: 227 cases without microinvasion Eur J Cancer 28 630 634
31. GF Schwartz LJ Solin IA Olivotto 2000 Consensus conference on the treatment of in situ ductal carcinoma of the breast, April 22-25, 1999 Cancer 88 946 954
32. KJ Van Zee L Liberman B Samli 1999 Long term follow-up of women with ductal carcinoma in situ treated with breast-conserving surgery: the effect of age Cancer 86 1757 1767
33. LJ Solin I Yeh J Kurtz 1993 Ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive irradiation Cancer 71 2532 2542
34. U Veronesi E Marubini L Mariani V Galimberti A Luini P Veronesi B Salvadori R Zucali 2001 Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial Ann Oncol 12 7 997 1003
35. MC Ryoo AR Kagan M Wollin 1989 Prognostic factors for recurrence and cosmesis in 393 patients after radiation therapy for early mammary carcinoma Radiology 172 555 559
36. R Heimann C Powers HJ Halpern 1996 Breast preservation in stage I and II carcinoma of the breast. The university of Chicago experience Cancer 78 1722 1730
37. JP Julien N Bijker IS Fentiman 2000 Radiotherapy in breast-conserving treatment for ductal carcinoma in situ: first results of the EORTC randomized phase III trial 10853 Lancet 355 528 533
38. JM Kurtz 1992 Factors influencing the risk of local recurrence in the breast Eur J Cancer 28 660 666
39. J Borger H Kemperman A Hart 1994 Risk factors in breast conservation therapy J Clin Oncol 12 653 660
40. F Darvishian SI Hajdu DC DeRisi 2003 Significance of linear extent of breast carcinoma at surgical margin Ann Surg Oncol 1 48 51
41. NQ Mirza G Vlastos F Meric 2002 Predictors of locoregional recurrence among patients with early-stage breast cancer treated with breast-conserving therapy Ann Surg Oncol 9 256 265
42. S Ohsumi S Takashima T Saeki K Aogi 2002 Breast-conserving therapy of wide excision, axillary dissection, and radiotherapy for early-stage breast cancer: the experience of the National Shikoku Cancer Center Biomed Pharmacother 56 196 200
43. MJ Silverstein MD Lagios S Groshem 1999 The influence of margin width on local control of ductal carcinoma in situ of the breast N Engl J Med 340 1455 1461
44. DH Clarke MG Le D Sarrazing 1985 Analysis of local regional relapses in patients with early breast cancers treated by excision and radiotherapy: experience of the institute Gustave-Roussy Int J Radiat Oncol Biol Phys 11 137 145
45. JA Dewar R Arriagada S Benhamou 1995 Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982) Cancer 76 2260 2265
46. A Forquet F Campana B Zafrani 1989 Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-years follow-up Int J Radiat Oncol Biol Phys 17 719 725
47. U Veronesi B Salvadori A Luini M Greco R Saccozzi M del Vecchio L Mariani S Zurrida F Rilke 1995 Breast conservation is a safe method in patients with small cancer of the breast. Long-term results of three randomised trials on 1,973 patients Eur J Cancer 31A 10 1574 1579
48. S Zurrida A Costa A Luini 2001 The Veronesi quadrantectomy: an established procedure for the conservative treatment of early breast cancer Int J Surg Investig 2 6 423 431
49. PA Holland A Gandhi WF Knox M Wilson AD Baildam NJ Bundred 1998 The importance of complete excision in the prevention of local recurrence of ductal carcinoma in situ Br J Cancer 77 110 114
50. U Veronesi F Volterrani A Luini 1990 Quadrantectomy versus lumpectomy for small size breast cancer Eur J Cancer 26 6 671 673
51. A Wallgren M Bonetti RD Gelber 2003 Risk factors for locoregional recurrence among breast cancer patients: results from International Breast Cancer Study Group Trials I through VII J Clin Oncol 21 1205 1213