The Golgi puppet master: COG complex at center stage of membrane trafficking interactions

Histochemistry and Cell Biology

Volumn 140, Issue 3, 2013, Pages 271-283

  Willett, Rose ^a   Ungar, Daniel ^b   Lupashin, Vladimir ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

COG; Golgi; Membrane trafficking; Rab; SNARE; Tether

Indexed keywords

COAT PROTEIN COMPLEX I; PROTEIN SM; RAB PROTEIN; SNARE PROTEIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

CONSERVED OLIGOMERIC GOLGI COMPLEX; EUKARYOTIC CELL; GLYCOSYLATION; GOLGI COMPLEX; HOMEOSTASIS; HUMAN; IMMUNOGOLD ELECTRON MICROSCOPY; MEMBRANE FUSION; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; REVIEW; WESTERN BLOTTING; ANIMAL; CHEMISTRY; INTRACELLULAR MEMBRANE; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

EUKARYOTA;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BIOLOGICAL TRANSPORT; EUKARYOTIC CELLS; GLYCOSYLATION; GOLGI APPARATUS; HOMEOSTASIS; HUMANS; INTRACELLULAR MEMBRANES;

EID: 84887478931     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-013-1117-6     Document Type: Review

References (82)

1. Arabidopsis Interactome Mapping C (2011) Evidence for network evolution in an Arabidopsis interactome map. Science 333(6042):601-607. doi: 10.1126/science.1203877
2. Arasaki K, Taniguchi M, Tani K, Tagaya M (2006) RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. Mol Biol Cell 17(6):2780-2788. doi: 10.1091/mbc.E05-10-0973
3. Bonifacino JS, Glick BS (2004) The mechanisms of vesicle budding and fusion. Cell 116(2):153-166
4. Boxem M, Maliga Z, Klitgord N, Li N, Lemmens I, Mana M, de Lichtervelde L, Mul JD, van de Peut D, Devos M, Simonis N, Yildirim MA, Cokol M, Kao HL, de Smet AS, Wang H, Schlaitz AL, Hao T, Milstein S, Fan C, Tipsword M, Drew K, Galli M, Rhrissorrakrai K, Drechsel D, Koller D, Roth FP, Iakoucheva LM, Dunker AK, Bonneau R, Gunsalus KC, Hill DE, Piano F, Tavernier J, van den Heuvel S, Hyman AA, Vidal M (2008) A protein domain-based interactome network for C. elegans early embryogenesis. Cell 134(3):534-545. doi: 10.1016/j.cell.2008.07. 009
5. Burkhardt P, Hattendorf DA, Weis WI, Fasshauer D (2008) Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J 27(7):923-933. doi: 10.1038/emboj.2008.37
6. Carr CM, Grote E, Munson M, Hughson FM, Novick PJ (1999) Sec1p binds to SNARE complexes and concentrates at sites of secretion. J Cell Biol 146(2):333-344. doi: 10.1083/jcb.146.2.333
7. Chen S, Cai H, Park SK, Menon S, Jackson CL, Ferro-Novick S (2011) Trs65p, a subunit of the Ypt1p GEF TRAPPII, interacts with the Arf1p exchange factor Gea2p to facilitate COPI-mediated vesicle traffic. Mol Biol Cell 22(19):3634-3644. doi: 10.1091/mbc.E11-03-0197
8. Collins KM, Thorngren NL, Fratti RA, Wickner WT (2005) Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion. EMBO J 24(10):1775-1786. doi: 10.1038/sj.emboj.7600658
9. Cottam NP, Ungar D (2012) Retrograde vesicle transport in the Golgi. Protoplasma 249(4):943-955. doi: 10.1007/s00709-011-0361-7
10. Domanska MK, Kiessling V, Stein A, Fasshauer D, Tamm LK (2009) Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion. J Biol Chem 284(46):32158-32166. doi: 10.1074/jbc.M109.047381
11. Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Sudhof TC, Rizo J (1999) A conformational switch in syntaxin during exocytosis: role of munc18. EMBO J 18(16):4372-4382. doi: 10.1093/emboj/18.16.4372
12. Dulubova I, Yamaguchi T, Gao Y, Min SW, Huryeva I, Sudhof TC, Rizo J (2002) How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J 21(14):3620-3631. doi: 10.1093/emboj/cdf381
13. Fernandez I, Ubach J, Dulubova I, Zhang X, Sudhof TC, Rizo J (1998) Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. Cell 94(6):841-849
14. Fotso P, Koryakina Y, Pavliv O, Tsiomenko AB, Lupashin VV (2005) Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex. J Biol Chem 280(30):27613-27623. doi: 10.1074/jbc.M504597200
15. Fukuda M, Kanno E, Ishibashi K, Itoh T (2008) Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. Mol Cell Proteomics 7(6):1031-1042. doi: 10.1074/mcp.M700569-MCP200
16. Gerber SH, Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Sudhof TC (2008) Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science 321(5895):1507-1510. doi: 10.1126/science.1163174
17. Giot L, Bader JS, Brouwer C, Chaudhuri A, Kuang B, Li Y, Hao YL, Ooi CE, Godwin B, Vitols E, Vijayadamodar G, Pochart P, Machineni H, Welsh M, Kong Y, Zerhusen B, Malcolm R, Varrone Z, Collis A, Minto M, Burgess S, McDaniel L, Stimpson E, Spriggs F, Williams J, Neurath K, Ioime N, Agee M, Voss E, Furtak K, Renzulli R, Aanensen N, Carrolla S, Bickelhaupt E, Lazovatsky Y, DaSilva A, Zhong J, Stanyon CA, Finley RL Jr, White KP, Braverman M, Jarvie T, Gold S, Leach M, Knight J, Shimkets RA, McKenna MP, Chant J, Rothberg JM (2003) A protein interaction map of Drosophila melanogaster. Science 302(5651):1727-1736. doi: 10.1126/science.1090289
18. Glick BS, Elston T, Oster G (1997) A cisternal maturation mechanism can explain the asymmetry of the Golgi stack. FEBS Lett 414(2):177-181. doi: 10.1016/S0014-5793(97)00984-8
19. Gokhale A, Larimore J, Werner E, So L, Moreno-De-Luca A, Lese-Martin C, Lupashin VV, Smith Y, Faundez V (2012) Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1. J Neurosci 32(11):3697-3711. doi: 10.1523/JNEUROSCI.5640-11.2012
20. Guo W, Roth D, Walch-Solimena C, Novick P (1999) The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. EMBO J 18(4):1071-1080. doi: 10.1093/emboj/18.4.1071
21. Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (2004) Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. EMBO J 23(6):1267-1278. doi: 10.1038/sj.emboj.7600135
22. Hua Y, Scheller RH (2001) Three SNARE complexes cooperate to mediate membrane fusion. Proc Natl Acad Sci USA 98(14):8065-8070. doi: 10.1073/pnas.131214798
23. Hutagalung AH, Novick PJ (2011) Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev 91(1):119-149. doi: 10.1152/physrev.00059.2009
24. Kingsley DM, Kozarsky KF, Segal M, Krieger M (1986) Three types of low density lipoprotein receptor-deficient mutant have pleiotropic defects in the synthesis of N-linked, O-linked, and lipid- linked carbohydrate chains. J Cell Biol 102(5):1576-1585
25. Kloepper TH, Kienle CN, Fasshauer D (2007) An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system. Mol Biol Cell 18(9):3463-3471. doi: 10.1091/mbc.E07-03-0193
26. Kristensen AR, Gsponer J, Foster LJ (2012) A high-throughput approach for measuring temporal changes in the interactome. Nat Methods 9(9):907-909. doi: 10.1038/nmeth.2131
27. Kudlyk T, Willett R, Pokrovskaya ID, Lupashin V (2013) COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity. Traffic 14(2):194-204. doi: 10.1111/tra.12020
28. Laufman O, Kedan A, Hong W, Lev S (2009) Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. EMBO J 28(14):2006-2017. doi: 10.1038/emboj.2009.168
29. Laufman O, Hong W, Lev S (2011) The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport. J Cell Biol 194(3):459-472. doi: 10.1083/jcb.201102045
30. Laufman O, Hong W, Lev S (2013) The COG complex interacts with multiple Golgi SNAREs and enhances fusogenic assembly of SNARE complexes. J Cell Sci 126(Pt 6):1506-1516. doi: 10.1242/jcs.122101
31. Li S, Armstrong CM, Bertin N, Ge H, Milstein S, Boxem M, Vidalain PO, Han JD, Chesneau A, Hao T, Goldberg DS, Li N, Martinez M, Rual JF, Lamesch P, Xu L, Tewari M, Wong SL, Zhang LV, Berriz GF, Jacotot L, Vaglio P, Reboul J, Hirozane-Kishikawa T, Li Q, Gabel HW, Elewa A, Baumgartner B, Rose DJ, Yu H, Bosak S, Sequerra R, Fraser A, Mango SE, Saxton WM, Strome S, Van Den Heuvel S, Piano F, Vandenhaute J, Sardet C, Gerstein M, Doucette-Stamm L, Gunsalus KC, Harper JW, Cusick ME, Roth FP, Hill DE, Vidal M (2004) A map of the interactome network of the metazoan C. elegans. Science 303(5657):540-543. doi: 10.1126/science.1091403
32. McNew JA, Parlati F, Fukuda R, Johnston RJ, Paz K, Paumet F, Sollner TH, Rothman JE (2000) Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature 407(6801):153-159. doi: 10.1038/35025000
33. Miller VJ, Ungar D (2012) Re'COG'nition at the Golgi. Traffic 13(7):891-897
34. Miller VJ, Sharma P, Kudlyk TA, Frost L, Rofe AP, Watson IJ, Duden R, Lowe M, Lupashin VV, Ungar D (2013) Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF). J Biol Chem 288(6):4229-4240. doi: 10.1074/jbc.M112.426767
35. Misura KM, Scheller RH, Weis WI (2000) Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex [see comments]. Nature 404(6776):355-362
36. Morgera F, Sallah MR, Dubuke ML, Gandhi P, Brewer DN, Carr CM, Munson M (2012) Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1. Mol Biol Cell 23(2):337-346. doi: 10.1091/mbc.E11-08-0670
37. Munro S (2011) The golgin coiled-coil proteins of the Golgi apparatus. Cold Spring Harb Perspect Biol 3 (6). doi: 10.1101/cshperspect.a005256
38. Oka T, Ungar D, Hughson FM, Krieger M (2004) The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. Mol Biol Cell 15(5):2423-2435. doi: 10.1091/mbc.E03-09-0699
39. Parlati F, McNew JA, Fukuda R, Miller R, Sollner TH, Rothman JE (2000) Topological restriction of SNARE-dependent membrane fusion [see comments]. Nature 407(6801):194-198
40. Perez-Victoria FJ, Bonifacino JS (2009) Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. Mol Cell Biol 29(19):5251-5263. doi: 10.1128/MCB.00495-09
41. Pokrovskaya ID, Willett R, Smith RD, Morelle W, Kudlyk T, Lupashin VV (2011) Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery. Glycobiology 21(12):1554-1569. doi: 10.1093/glycob/cwr028
42. Rabouille C, Levine TP, Peters JM, Warren G (1995) An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments. Cell 82(6):905-914
43. Rabouille C, Kondo H, Newman R, Hui N, Freemont P, Warren G (1998) Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro. Cell 92(5):603-610. doi: 10.1016/S0092-8674(00)81128-9
44. Ram RJ, Li BJ, Kaiser CA (2002) Identification of Sec36p, Sec37p, and Sec38p: components of yeast complex that contains Sec34p and Sec35p. Mol Biol Cell 13(5):1484-1500. doi: 10.1091/mbc.01-10-0495
45. Ramirez IB, Lowe M (2009) Golgins and GRASPs: holding the Golgi together. Semin Cell Dev Biol 20(7):770-779. doi: 10.1016/j.semcdb.2009.03.011
46. Rothman JE, Wieland FT (1996) Protein sorting by transport vesicles. Science 272(5259):227-234
47. Schultz J, Doerks T, Ponting CP, Copley RR, Bork P (2000) More than 1,000 putative new human signalling proteins revealed by EST data mining. Nat Genet 25(2):201-204. doi: 10.1038/76069
48. Sengupta D, Truschel S, Bachert C, Linstedt AD (2009) Organelle tethering by a homotypic PDZ interaction underlies formation of the Golgi membrane network. J Cell Biol 186(1):41-55. doi: 10.1083/jcb.200902110
49. Shestakova A, Zolov S, Lupashin V (2006) COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation. Traffic 7(2):191-204. doi: 10.1111/j.1600-0854.2005.00376.x
50. Shestakova A, Suvorova E, Pavliv O, Khaidakova G, Lupashin V (2007) Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability. J Cell Biol 179(6):1179-1192. doi: 10.1083/jcb.200705145
51. Simonis N, Rual JF, Carvunis AR, Tasan M, Lemmens I, Hirozane-Kishikawa T, Hao T, Sahalie JM, Venkatesan K, Gebreab F, Cevik S, Klitgord N, Fan C, Braun P, Li N, Ayivi-Guedehoussou N, Dann E, Bertin N, Szeto D, Dricot A, Yildirim MA, Lin C, de Smet AS, Kao HL, Simon C, Smolyar A, Ahn JS, Tewari M, Boxem M, Milstein S, Yu H, Dreze M, Vandenhaute J, Gunsalus KC, Cusick ME, Hill DE, Tavernier J, Roth FP, Vidal M (2009) Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Nat Methods 6(1):47-54
52. Siniossoglou S, Pelham HR (2002) Vps51p links the VFT complex to the SNARE Tlg1p. J Biol Chem 277(50):48318-48324. doi: 10.1074/jbc.M209428200
53. Sohda M, Misumi Y, Yoshimura S, Nakamura N, Fusano T, Ogata S, Sakisaka S, Ikehara Y (2007) The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity. Traffic 8(3):270-284. doi: 10.1111/j.1600-0854.2006.00530.x
54. Sohda M, Misumi Y, Yamamoto A, Nakamura N, Ogata S, Sakisaka S, Hirose S, Ikehara Y, Oda K (2010) Interaction of Golgin-84 with the COG complex mediates the intra-Golgi retrograde transport. Traffic 11(12):1552-1566. doi: 10.1111/j.1600-0854.2010.01123.x
55. Söllner T, Bennett MK, Whiteheart SW, Scheller RH, Rothman JE (1993) A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell 75(3):409-418
56. Struwe WB, Reinhold VN (2012) The conserved oligomeric Golgi complex is required for fucosylation of N-glycans in Caenorhabditis elegans. Glycobiology 22(6):863-875. doi: 10.1093/glycob/cws053
57. Sutton RB, Fasshauer D, Jahn R, Brunger AT (1998) Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature 395(6700):347-353. doi: 10.1038/26412
58. Suvorova ES, Duden R, Lupashin VV (2002) The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins. J Cell Biol 157(4):631-643. doi: 10.1083/jcb.200111081
59. Tang BL, Low DY, Lee SS, Tan AE, Hong W (1998) Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins. Biochem Biophys Res Commun 242(3):673-679. doi: 10.1006/bbrc.1997.8029
60. Tarassov K, Messier V, Landry CR, Radinovic S, Molina MMS, Shames I, Malitskaya Y, Vogel J, Bussey H, Michnick SW (2008) An in vivo map of the yeast protein interactome. Science 320(5882):1465-1470. doi: 10.1126/science.1153878
61. Toikkanen JH, Miller KJ, Soderlund H, Jantti J, Keranen S (2003) The beta subunit of the Sec61p endoplasmic reticulum translocon interacts with the exocyst complex in Saccharomyces cerevisiae. J Biol Chem 278(23):20946-20953. doi: 10.1074/jbc.M213111200
62. Uchiyama K, Kondo H (2005) p97/p47-mediated biogenesis of Golgi and ER. J Biochem 137(2):115-119. doi: 10.1093/jb/mvi028
63. Uetz P, Giot L, Cagney G, Mansfield TA, Judson RS, Knight JR, Lockshon D, Narayan V, Srinivasan M, Pochart P, Qureshi-Emili A, Li Y, Godwin B, Conover D, Kalbfleisch T, Vijayadamodar G, Yang M, Johnston M, Fields S, Rothberg JM (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403(6770):623-627. doi: 10.1038/35001009
64. Ullrich O, Stenmark H, Alexandrov K, Huber LA, Kaibuchi K, Sasaki T, Takai Y, Zerial M (1993) Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins. J Biol Chem 268(24):18143-18150
65. Ungar D, Hughson FM (2003) SNARE protein structure and function. Annu Rev Cell Dev Biol 19:493-517. doi: 10.1146/annurev.cellbio.19.110701.155609
66. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (2002) Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. J Cell Biol 157(3):405-415. doi: 10.1083/jcb.200202016
67. Ungar D, Oka T, Vasile E, Krieger M, Hughson FM (2005) Subunit architecture of the conserved oligomeric Golgi complex. J Biol Chem 280(38):32729-32735. doi: 10.1074/jbc.M504590200
68. VanRheenen SM, Cao X, Lupashin VV, Barlowe C, Waters MG (1998) Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking. J Cell Biol 141(5):1107-1119
69. Vasile E, Oka T, Ericsson M, Nakamura N, Krieger M (2006) IntraGolgi distribution of the conserved oligomeric Golgi (COG) complex. Exp Cell Res 312(16):3132-3141. doi: 10.1016/j.yexcr.2006.06.005
70. Volchuk A, Ravazzola M, Perrelet A, Eng WS, Di Liberto M, Varlamov O, Fukasawa M, Engel T, Sollner TH, Rothman JE, Orci L (2004) Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol Biol Cell 15(4):1506-1518. doi: 10.1091/mbc.E03-08-0625
71. Weber T, Zemelman BV, McNew JA, Westermann B, Gmachl M, Parlati F, Sollner TH, Rothman JE (1998) SNAREpins: minimal machinery for membrane fusion. Cell 92(6):759-772
72. Whyte JRC, Munro S (2001) The SeC34/35 golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. Dev Cell 1(4):527-537. doi: 10.1016/S1534-5807(01)00063-6
73. Willett R, Kudlyk T, Pokrovskaya I, Schonherr R, Ungar D, Duden R, Lupashin V (2013) COG complexes form spatial landmarks for distinct SNARE complexes. Nat Commun 4:1553. doi: 10.1038/ncomms2535
74. Wu X, Steet RA, Bohorov O, Bakker J, Newell J, Krieger M, Spaapen L, Kornfeld S, Freeze HH (2004) Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder. Nat Med 10(5):518-523. doi: 10.1038/nm1041
75. Wuestehube LJ, Duden R, Eun A, Hamamoto S, Korn P, Ram R, Schekman R (1996) New mutants of Saccharomyces cerevisiae affected in the transport of proteins from the endoplasmic reticulum to the Golgi complex. Genetics 142(2):393-406
76. Xu D, Joglekar AP, Williams AL, Hay JC (2000) Subunit structure of a mammalian ER/Golgi SNARE complex [in process citation]. J Biol Chem 275(50):39631-39639
77. Yu H, Braun P, Yildirim MA, Lemmens I, Venkatesan K, Sahalie J, Hirozane-Kishikawa T, Gebreab F, Li N, Simonis N, Hao T, Rual JF, Dricot A, Vazquez A, Murray RR, Simon C, Tardivo L, Tam S, Svrzikapa N, Fan C, de Smet AS, Motyl A, Hudson ME, Park J, Xin X, Cusick ME, Moore T, Boone C, Snyder M, Roth FP, Barabasi AL, Tavernier J, Hill DE, Vidal M (2008) High-quality binary protein interaction map of the yeast interactome network. Science 322(5898):104-110. doi: 10.1126/science.1158684
78. Yu CC, Yang JC, Chang YC, Chuang JG, Lin CW, Wu MS, Chow LP (2013) VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. PLoS ONE 8(1):e55724. doi: 10.1371/journal.pone.0055724
79. Zeevaert R, Foulquier F, Jaeken J, Matthijs G (2008) Deficiencies in subunits of the Conserved Oligomeric Golgi (COG) complex define a novel group of Congenital Disorders of Glycosylation. Mol Genet Metab 93(1):15-21. doi: 10.1016/j.ymgme.2007.08.118
80. Zerial M, McBride H (2001) Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2(2):107-117
81. Zhang XM, Ellis S, Sriratana A, Mitchell CA, Rowe T (2004) Sec15 is an effector for the Rab11 GTPase in mammalian cells. J Biol Chem 279(41):43027-43034. doi: 10.1074/jbc.M402264200
82. Zolov SN, Lupashin VV (2005) Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells. J Cell Biol 168(5):747-759. doi: 10.1083/jcb.200412003