Conformational switch of syntaxin-1 controls synaptic vesicle fusion

Science

Volumn 321, Issue 5895, 2008, Pages 1507-1510

  Gerber, Stefan H ^a,f   Rah, Jong Cheol ^b,c,g   Min, Sang Won ^a,h   Liu, Xinran ^a   De Wit, Heidi ^d   Dulubova, Irina ^a   Meyer, Alexander C ^c   Rizo, Josep ^a   Arancillo, Marife ^b   Hammer, Robert E ^a   Verhage, Matthijs ^d   Rosenmund, Christian ^b,c   Südhof, Thomas C ^a,e,i  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^d VU UNIVERSITY AMSTERDAM   (Netherlands)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f UNIVERSITY OF HEIDELBERG   (Germany)

^g NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUNC18 PROTEIN; MUTANT PROTEIN; SNARE PROTEIN; SYNTAXIN 1;

BRAIN; PROTEIN; RODENT;

ARTICLE; ELECTRON MICROSCOPY; EXOCYTOSIS; GENE MUTATION; GRAND MAL SEIZURE; HIPPOCAMPUS; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SYNAPSE VESICLE;

ANIMALS; CALCIUM; EPILEPSY; EXCITATORY POSTSYNAPTIC POTENTIALS; MEMBRANE FUSION; MICE; MICE, KNOCKOUT; MUNC18 PROTEINS; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SNARE PROTEINS; SUCROSE; SYNAPSES; SYNAPTIC VESICLES; SYNTAXIN 1;

MUS;

EID: 51749100843     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1163174     Document Type: Article

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24. We thank N. Hamlin, I. Kornblum, A. Roth, I. Herfort, and E. Borowicz for technical assistance. This work was supported by grants from Deutsche Forschungsgemeinschaft (GE1042/1-1, GE1042/3-1, and GE1042/3-2 to S.H.G. and Ro1296/5-3 to C.R.), NIH (NS051262 to C.R. and NS37200 to J.R.), and Netherlands Organization for Scientific Research (GpD970-10-036 and 900-01-001 to M.V. and 916-36-043 to H.d.W.).