Design, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents

Medicinal Chemistry Research

Volumn 22, Issue 11, 2013, Pages 5610-5616

  Xu, Shengjie ^a   Li, Shenghui ^a   Tang, Yonghe ^a   Zhang, Jinchao ^a   Wang, Shuxiang ^a   Zhou, Chuanqi ^a   Li, Xiaoliu ^a  

^a HEBEI UNIVERSITY   (China)

Author keywords

Aromatic substitution; Cancer cell lines; Cytotoxicity; N Arylpyrazole; Pyrazole

Indexed keywords

1 (4 NITROPHENYL) 4 [4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE; 1,2 BIS(3,5 DIMETHYL 1H PYRAZOL 4 YL)BENZENE; 1,2 BIS[3,5 DIMETHYL 1 (4 NITROPHENYL)PYRAZOL 4 YL]BENZENE; 1,3 BIS(3,5 DIMETHYL 1H PYRAZOL 4 YL)BENZENE; 1,3 BIS[3,5 DIMETHYL 1 (4 NITROPHENYL)PYRAZOL 4 YL]BENZENE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 (1H PYRAZOL 4 YL)PYRIDINE; 4 (4 NITROPHENYL) 1 (4 NITROPHENYL) 1H PYRAZOLE; 4 (4 NITROPHENYL) 1H PYRAZOLE; 4 [1 (4 NITROPHENYL) 1H PYRAZOL 4 YL]PYRIDINE; 4 [3,5 BIS(TRIFLUOROMETHYL)PHENYL] 1 (4 NITROPHENYL) 1H PYRAZOLE; 4 [3,5 BIS(TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE; 4 [4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE; 4,4' [5 (OCTYLOXY) 1,3 PHENYLENE]BIS(3,5 DIMETHYL 1H PYRAZOLE); 4,4' [5 (OCTYLOXY) 1,3 PHENYLENE]BIS[3,5 DIMETHYL 1 (4 NITROPHENYL)PYRAZOLE]; BENZENE DERIVATIVE; CARBON; CISPLATIN; CYTOTOXIC AGENT; HYDROGEN; NITROGEN; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NASOPHARYNX CARCINOMA; PROTON NUCLEAR MAGNETIC RESONANCE; STOMACH CARCINOMA; SUBSTITUTION REACTION;

EID: 84887477070     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0552-1     Document Type: Article

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