Design, synthesis and biological evaluation of some novel substituted 2-mercapto-3-phenethylquinazolines as antitumor agents

Medicinal Chemistry Research

Volumn 22, Issue 11, 2013, Pages 5566-5577

  Alanazi, Amer M ^a   Al Suwaidan, Ibrahim A ^a   Abdel Aziz, Alaa A M ^a,b   Mohamed, Menshawy A ^c,d   El Morsy, Ahmad M ^c   El Azab, Adel S ^a,c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b University of Mansoura   (Egypt)

^c Cairo University   (Egypt)

^d PRINCE SATTAM BIN ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

In vitro antitumor evaluation; NCI; Quinazoline; Selective activity; Synthesis

Indexed keywords

2 (2 MORPHOLINOETHYLTHIO) 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 (2 OXO 2 PHENYLETHYLTHIO) 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 (4 CHLOROBENZYLTHIO) 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 (4 NITROBENZYLTHIO) 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETOHYDRAZIDE; 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETONITRILE; 2 (BENZYLTHIO) 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 (ETHYLTHIO) 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 (METHYLTHIO) 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 [(4 BENZYL 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL)METHYLTHIO] 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 [(4 ETHYL 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL)METHYLTHIO] 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 [(5 MERCAPTO 4 PHENYL 4H 1,2,4 TRIAZOL 3 YL)METHYLTHIO] 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 [2 (4 FLUOROPHENYL) 2 OXOETHYLTHIO] 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 [2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETYL]N PHENYLHYDRAZINECARBOTHIOAMIDE; 2 [2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ETHYL]ISOINDOLINE 1,3 DIONE; 2 [3 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)PROPYL]ISOINDOLINE 1,3 DIONE; 2 [[5 MERCAPTO 4 (4 METHOXYPHENYL) 4H 1,2,4 TRIAZOL 3 YL]METHYLTHIO] 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 2 MERCAPTO 3 PHENETHYLQUINAZOLIN 4 (3H)ONE; 3 PHENETHYL 2 [2 (PIPERIDIN 1 YL)ETHYLTHIO]QUINAZOLIN 4 (3H)ONE; 4 [(4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)METHYL]BENZOIC ACID; ANTINEOPLASTIC AGENT; ETHYL 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETATE; N BENZYL 2 [2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETYL]HYDRAZINECARBOTHIOAMIDE; N ETHYL 2 [2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETYL]HYDRAZINECARBOTHIOAMIDE; N(4 FLUOROPHENYL) 2 [2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETYL]HYDRAZINECARBOTHIOAMIDE; N(4 METHOXYPHENYL) 2 [2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETYL]HYDRAZINECARBOTHIOAMIDE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; DERIVATIZATION; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CANCER; LEUKEMIA; LUNG NON SMALL CELL CANCER; MELANOMA; OVARY CANCER; PROSTATE CANCER;

EID: 84887458720     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0546-z     Document Type: Article

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