Modified oligonucleotides: Strides towards antisense drugs

Trends in Carbohydrate Research

Volumn 5, Issue 3, 2013, Pages 1-7

  Sharma, Vivek K ^a   Kumar, Rajesh ^a   Rungta, Pallavi ^a   Parmar, Virinder S ^a   Prasad, Ashok K ^a  

^a UNIVERSITY OF DELHI   (India)

Author keywords

Antisense therapeutics; Locked nucleic acid; Modified oligonucleotides; Peptide nucleic acid and phosphorodiamidate morpholino modification; Phosphate backbone modification; Phosphorothioate linkage; Sugar modified nucleosides

Indexed keywords

EID: 84887387999     PISSN: None     EISSN: 09750304     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Zamecmk, P. C; Stephenson, M. L. Proc. Natl. Acad. Sci, USA 1978, 75, 280.
2. Mulamba, G. B.; Hu, A; Azad, R. F.; Anderson, K. P.; Coen, D. M. Antimicrob. Agents Chemother. I998, 42, 97l.
3. McGowan, M. P.; Tardtf, J.; Ceska, R; Burgess, L. J.; Soran, H, Goum-Berthold, I.; Wagener, G.; Chasan-Taber, S. PLoS One 2012, 7, e49006.
4. Corey, D.R.J. Clin. Invest. 2007, 117, 3615.
5. Mickelfield, J. Curr. Med. Chem.2001, 8, 1157.
6. (a) Prakash, T. P.; Kawasala, A. M.; Wancewicz, E. V.; Shen, L, Monia, B. P.; Ross, B. S.; Bhat, B.; Manoharan, M. J. Med. Chem. 2008, 51, 2766
7. (b) Wengel, J. ACC. Chem. Res. 1999, 52, 301.
8. (a) Xie, X.; Uang, J.; Pu, T.; Xu, F; Yao, F; Yang, Y; Zhao, Y L, You, D.; Zhou, X.; Deng, Z.; Wang, Z. Nucleic Acids Res. 2012, 40, 9115.
9. (b) Rahman, S. M.; Baba, T.; Kodama, T.; Islam, MA; Obika, S. Bioorg. Med. Chem. 2012, 20, 4098.
10. (c) DeClerq, E, Eckstein, F.; Mengan, T. C. Science 1969, 165, 1137.
11. (a) Monn, S. T.; Schürch, S. J. Am. Soc. Mass Spectrom. 2007, 18, 984.
12. (b) Shoji, Y;Akhtar, S.; Penasamy, A.; Herman, B.; Juliano, R.L. Nucleic Acids Res. 1991, 19, 5543
13. (a) Crooke, S. T. Therapeutic applications of oligonucleotides, Austin, Ed. Landes, R. G 1995
14. (b) Coughlin, IE.; Pandey, R. K; Padmanabhan, S.; O'Loughlm, K. G; Marquis, J.; Green, C. E.; Mirsalis, J. C.; Iyer, R P. Drug Metab. Dispos. 2012, 40, 970.
15. (a) Yamada, T.; Okaniwa, N.; Saneyoshi, H.; Ohkubo, A.; Seio, K; Nagata, T.; Aoki, Y; Takeda, S; Sekine, M. J. Org. Chem. 2011, 76, 3042.
16. (b) Cummms, L. L.; Owens, S. R.; Risen, L. M, Lesnik, E.A.; Freier, S. M; McGee, D.; Guinosso, C. J.; Cook, P D. Nucleic Acids Res. 1995, 23, 2019.
17. Prakash, T.P. Chem. Biodivers.2011, 8, 1616.
18. SproatB.S.; Lamond, A.L; Beyer, B.; Neuner, P.; Ryder, U. Nucleic Acids Res. 1989,17,3313.
19. (a) Seth, P. P.; Jazayeri, A.; Yu, J.; Allerson, C. R; Bhat, B, Swayze, E. E. Mol. Ther Nucleic Acids 2012, 1, e47.
20. (b) Monia, B. P; Lesnik, E. A.; Gonzalez, C; Lima, W. F; McGee, D.; Guinosso, C. J.; Kawasaki, A. M; Cook, P. D.; Freier, S. M. J. Biol. Chem. 1993, 268, 14514.
21. Mesmaeker, A.D.; Häner, R; Martm, P.; Moser, H.E. ACC. Chem Res. 1995, 28, 366.
22. Guschlbauer, W.; Jankowski, K. Nucleic Acids Res. 1980, 8, 1421.
23. (a) Saenger, W. Principles of nucleic acid structures, Springer-Verlag, New York 1984.
24. (b) Prakash, T. P.; Bhat, B. Curr Top. Med Chem.2001, 7, 641
25. Kurreck, J. Eur. J. Biochem. 2003, 270, 1628.
26. Gleave, M. E.; Monia, B.P. Nat. Rev. Cancer2005, 5, 468.
27. (a) Nielsen, P. E.; Egholm, M; Berg, R H.; Buchardt, O. Science 1991, 254, 1497.
28. (b) Banerjee, A, Kumar, V. A. Bioorg. Med. Chem.2013, 21, 4092.
29. Nielson, P.E. Mol. Biotechnol. 2004, 26, 233.
30. Hildebrandt-Enksen, E. S.; Aarup, V.; Persson, R.; Hansen, H. F, Munk, M.E.; Orum, H. Nucleic. Acid. Ther. 2012, 22, 152.
31. Veedu, R. N.; Wengel, J. Chem. Biodivers. 2010, 7,536.
32. Bamasch, D.A.; CorSy, D.R. Chem. Biol. 2001, 8, 1.
33. Kurreck, J.; Wyszko, E.; Gillen, C; Erdmarm, V. A. Nucleic Acids Res.2002, 30, 1911.
34. Schnell, F J.; Crumley, S. L.; Mourich, D. V.; Iversen, P. L. Biores. OpenAccess2013, 2, 61.
35. Amantana, A.; Iversen, P. L. Curr. Opin. Pharmacol. 2005, J, 550.
36. Nelson, M. H.; Stein, D. A.; Kroeker, A. D.; Hatlevig, S. A, Iversen, P.L.; Moulton, H.M. Bioconjug. Chem. 2005, 16, 959
37. McCaffrey, A. P.; Meuse, L.; Karimi, M.; Contag, C. H.; Kay, M. A. Hepatology 2003,38,503.
38. Iversen, P. L.; Warren, T. K.; Wells, J. B.; Garza, N. L.; Mourich, D. V; Welch, L. S.; Panchal, R G; Bavari, S. Viruses 2012, 4, 2806.
39. Malerba, A.; Kang, J. K.; McClorey, M. G.; Saleh, A. F, Popplewell, L.; Gait, M. J.; Wood, M. J; Dickson, G Mol. Ther. Nucleic Acids2012, 1, e62.
40. Perry, C. M; Balfour, J.A. Drugs 1999, 57, 375.
41. Hair, P.; Cameron, F; McKeage, K. Drugs 2013, 73, 487.
42. (a) Akar, E. E.; Oner, V.; Küçükerdönmez, C.; Aydm, A. Y Int. J. Ophthalmol. 2013, 6,136.
43. (b) Ng, E. W.; Shima, D. T.; Calias, P, Cunningham, E. T. Jr.; Guyer D. R.; Adamis, A. P. Nat. Rev. Drug Discov. 2006, J, 123.
44. (c) Burnett, J. C.; Rossi, J. J. Chem. Biol. 2012, 19, 60.
45. Borthakur, G.; O'Brien, S. Blood and Lymphatic Cancer: Targets and Therapy 2012, 2, 137.
46. Jaschinski, F; Rothhammer, T.; Jachimczak, P.; Seitz, C, Schneider, A.; Schlingensiepen, K.H. Curr. Pharm. Biotechnol. 2011, 72, 2203.
47. Cursiefen, C; Bock, F; Horn, F K.; Kruse, F E.; Seitz, B, Borderie, V; Früh, B.; Thiel, M. A.; Wilhelm, F; Geudelin, B; Descohand, I.; Steuhl, K. P.; Hahn, A.; Meller, D. Ophthalmology 2009, 116, 1630.
48. Grossman, S. A.; Alavi, J. B.; Supko, J. G.; Carson, K. A.; Priet, R.; Dorr, F A.; Grundy, J. S.; Holmlund, J. T. Neuro-oncol. 2005, 7, 32.
49. Laskin, J. J.; Nicholas, G; Lee, C; Gitlitz, B.; Vincent, M, Cormier, Y; Stephenson, J.; Ung, Y; Sanborn, R.; Pressnail, B; Nugent, F, Nemunaitis, J, Gleave, M. E, Murray, N, Hao, D. J. Thorac. Oncol. 2012, 7, 519.
50. http://clinicaltrials.gov/ct2/results?term=GSK-2402968
51. Singerman, L. Retina 2009, 29, S49.
52. (a) http://www.gentium.com/products/defibrotide.
53. (b) Richardson, P. G; Soiffer, R J.; Antin, J. H.; Uno, H.; Jin, Z.; Kurtzberg, J.; Martin, P. L.; Steinbach, G; Murray, K. F; Vogelsang, G B; Chen, A. R; Krishnan, A.; Kernan, N. A.; Avigan, D. E.; Spitzer, T. R.; Shulman, H. M.; Di Salvo, D. N.; Revta, C.; Warren, D.; Momtaz, P.; Bradwin, G.; Wei, L. J.; Iacobelli. M.; McDonald, G B.; Guinan, E. C. Biol. Blood Marrow Transplant2010, 16, 1005.
54. (a) Kim, Y H.; Girardi, M.; Duvic, M.; Kuzel, T.; Link, B. K, Pinter-Brown, L.; Rook, A. H. J. Am. Acad. Dermatol. 2010, 63, 975.
55. (b) Murad, Y M.; Clay, T. M.; Lyerly, H. K.; Morse, M. A. Expert Opin. Biol Ther. 2007, 7, 1257.
56. (c) http://www.im.org/AcademicAffairs/Aging/IGP/ExpandingResearchEfforts/Documents/lCPG%207909.pdf
57. Barry, M.; Cooper, C. Expert Opin. Biol. Ther 2001, 7, 1131.
58. Yacyshyn, B.; Chey, W Y; Wedel, M. K; Yu, R. Z.; Paul, D, Chuang, E. Clin. Gastroenterol Hepatol. 2001, 5, 215.
59. (a) Sekhon, H. S.;London, C.A.; Sekhon, M.;Iversen, PL.;Devi, G. R. Lung Cancer 2008, 60, 347.
60. (b) http://investorrelations.avibio.com/phoenix.zhtml?c=64231&p=irol-newsArticle&ID=928275&highlight=
61. (a) http://www.drugfuture.com/chemdata/edifoligide-sodiumhtml.
62. (b) Hoel, A. W.; Conte, M. S. Cardiovasc Drug Rev.2001, 25, 221.