Synthesis of 2′-O-[2-(N-methylcarbamoyl)ethyl]ribonucleosides using oxa-michael reaction and chemical and biological properties of oligonucleotide derivatives incorporating these modified ribonucleosides

Journal of Organic Chemistry

Volumn 76, Issue 9, 2011, Pages 3042-3053

  Yamada, Takeshi ^a   Okaniwa, Natsuki ^a   Saneyoshi, Hisao ^a   Ohkubo, Akihiro ^a   Seio, Kohji ^a   Nagata, Tetsuya ^b   Aoki, Yoshitsugu ^b   Takeda, Shin'ichi ^b   Sekine, Mitsuo ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE; BASIC CONDITIONS; BIOLOGICAL PROPERTIES; CHIMERIC OLIGOMERS; DNA STRANDS; DYSTROPHIN; HYDROXYL GROUPS; MICHAEL REACTIONS; NUCLEIC ACID DRUGS; O-METHYL GROUP; OLIGORIBONUCLEOTIDES; PHOSPHORAMIDITES; PHOSPHOROTHIOATES; PRE-MRNA; RIBONUCLEOSIDES; SPLICING REACTIONS;

ADDITION REACTIONS; FUNCTIONAL GROUPS; NUCLEIC ACIDS; OLIGOMERS; REACTION INTERMEDIATES; RNA; SYNTHESIS (CHEMICAL);

OLIGONUCLEOTIDES;

2 (METHOXYCARBONYL)ETHYL; 2 (N METHYLCARBAMOYL)ETHYL; 2 (N,N DIMETHYLCARBAMOYL)ETHYL; ADENINE; ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY RNA; CYTOSINE; DYSTROPHIN; GUANINE; MESSENGER RNA; METHYL GROUP; NUCLEASE; OLIGOMER; OLIGONUCLEOTIDE; PHOSPHORAMIDOUS ACID; RIBONUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; URACIL; URIDINE DERIVATIVE; ACRYLIC ACID DERIVATIVE; HYDROXIDE; HYDROXIDE ION; OLIGORIBONUCLEOTIDE; ORGANOPHOSPHORUS COMPOUND; PURINE NUCLEOTIDE; RIBONUCLEASE; URIDINE;

ANIMAL TISSUE; ARTICLE; ASSAY; CHIMERA; EXON; HYBRIDIZATION; MICHAEL ADDITION; MOUSE; NONHUMAN; SYNTHESIS; ANIMAL; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; METABOLISM; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE; PH; RNA SPLICING;

ACRYLATES; ANIMALS; BASE SEQUENCE; DYSTROPHIN; EXONS; HYDROGEN-ION CONCENTRATION; HYDROXIDES; MICE; NUCLEIC ACID HYBRIDIZATION; OLIGORIBONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; PURINE NUCLEOTIDES; RIBONUCLEASES; RNA SPLICING; SUBSTRATE SPECIFICITY; URIDINE;

EID: 79955569494     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo101963z     Document Type: Article

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