메뉴 건너뛰기




Volumn 2, Issue 1, 2013, Pages 61-66

Development of novel bioanalytical methods to determine the effective concentrations of phosphorodiamidate morpholino oligomers in tissues and cells

Author keywords

drug discovery; gene regulation; nucleic acids; virology

Indexed keywords

MORPHOLINO OLIGONUCLEOTIDE;

EID: 84887324689     PISSN: None     EISSN: 21647860     Source Type: Journal    
DOI: 10.1089/biores.2012.0276     Document Type: Article
Times cited : (8)

References (14)
  • 1
    • 0030862707 scopus 로고    scopus 로고
    • Morpholino antisense oligomers: Design, preparation, and properties
    • Summerton J, Weller D. Morpholino antisense oligomers: design, preparation, and properties. Antisense Nucleic Acid Drug Dev. 1997;7:187-195.
    • (1997) Antisense Nucleic Acid Drug Dev , vol.7 , pp. 187-195
    • Summerton, J.1    Weller, D.2
  • 3
    • 0141497030 scopus 로고    scopus 로고
    • Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing
    • Sazani P, Kole R. Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing. J Clin Invest. 2003;112:481-486.
    • (2003) J Clin Invest , vol.112 , pp. 481-486
    • Sazani, P.1    Kole, R.2
  • 4
    • 77956436149 scopus 로고    scopus 로고
    • Advanced antisense therapies for postexposure protection against lethal filovirus infections
    • Warren TK, Warfield KL, Wells J, et al. Advanced antisense therapies for postexposure protection against lethal filovirus infections. Nat Med. 2010;16:991-994.
    • (2010) Nat Med , vol.16 , pp. 991-994
    • Warren, T.K.1    Warfield, K.L.2    Wells, J.3
  • 5
    • 69949107887 scopus 로고    scopus 로고
    • Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: A single-blind, placebo-controlled, dose-escalation, proof-of-concept study
    • Kinali M, Arechavala-Gomeza V, Feng L, et al. Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study. Lancet Neurol. 2009;8:918-928.
    • (2009) Lancet Neurol , vol.8 , pp. 918-928
    • Kinali, M.1    Arechavala-Gomeza, V.2    Feng, L.3
  • 6
    • 0037479844 scopus 로고    scopus 로고
    • Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase i safety study in humans
    • Iversen PL, Arora V, Acker AJ, et al. Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans. Clin Cancer Res. 2003;9:2510-2519.
    • (2003) Clin Cancer Res , vol.9 , pp. 2510-2519
    • Iversen, P.L.1    Arora, V.2    Acker, A.J.3
  • 7
    • 79960663328 scopus 로고    scopus 로고
    • Chemical and mechanistic toxicology evaluation of exon skipping phosphorodiamidate morpholino oligomers in mdx mice
    • Sazani P, Ness KP, Weller DL, et al. Chemical and mechanistic toxicology evaluation of exon skipping phosphorodiamidate morpholino oligomers in mdx mice. Int J Toxicol. 2011; 30:322-333.
    • (2011) Int J Toxicol. , vol.30 , pp. 322-333
    • Sazani, P.1    Ness, K.P.2    Weller, D.L.3
  • 8
    • 77951110750 scopus 로고    scopus 로고
    • Safety pharmacology and genotoxicity evaluation of AVI-4658
    • Sazani P, Weller DL, Shrewsbury SB. Safety pharmacology and genotoxicity evaluation of AVI-4658. Int J Toxicol. 2010;29:143-156.
    • (2010) Int J Toxicol. , vol.29 , pp. 143-156
    • Sazani, P.1    Weller, D.L.2    Shrewsbury, S.B.3
  • 9
    • 34547778409 scopus 로고    scopus 로고
    • Arginine-rich cellpenetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing
    • Marshall NB, Oda SK, London CA, et al. Arginine-rich cellpenetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing. J Immunol Methods. 2007;325:114-126.
    • (2007) J Immunol Methods , vol.325 , pp. 114-126
    • Marshall, N.B.1    Oda, S.K.2    London, C.A.3
  • 10
    • 4844225667 scopus 로고    scopus 로고
    • Neutrally charged phosphorodiamidate morpholino antisense oligomers: Uptake, efficacy and pharmacokinetics
    • Arora V, Devi GR, Iversen PL. Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. Curr Pharm Biotechnol. 2004;5: 431-439.
    • (2004) Curr Pharm Biotechnol , vol.5 , pp. 431-439
    • Arora, V.1    Devi, G.R.2    Iversen, P.L.3
  • 11
    • 22044438502 scopus 로고    scopus 로고
    • Quantification of oligodeoxynucleotides in human plasma with a novel hybridization assay offers greatly enhanced sensitivity over capillary gel electrophoresis
    • Efler SM, Zhang L, Noll BO, et al. Quantification of oligodeoxynucleotides in human plasma with a novel hybridization assay offers greatly enhanced sensitivity over capillary gel electrophoresis. Oligonucleotides. 2005;15: 119-131.
    • (2005) Oligonucleotides , vol.15 , pp. 119-131
    • Efler, S.M.1    Zhang, L.2    Noll, B.O.3
  • 12
    • 70349453645 scopus 로고    scopus 로고
    • Peptidemorpholino conjugate: A promising therapeutic for Duchenne muscular dystrophy
    • Moulton HM, Wu B, Jearawiriyapaisarn N, et al. Peptidemorpholino conjugate: a promising therapeutic for Duchenne muscular dystrophy. Ann NY Acad Sci. 2009;1175: 55-60.
    • (2009) Ann NY Acad Sci , vol.1175 , pp. 55-60
    • Moulton, H.M.1    Wu, B.2    Jearawiriyapaisarn, N.3
  • 13
    • 63449099709 scopus 로고    scopus 로고
    • Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection
    • Swenson DL, Warfield KL, Warren TK, et al. Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection. Antimicrob Agents Chemother. 2009;53:2089-2099.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2089-2099
    • Swenson, D.L.1    Warfield, K.L.2    Warren, T.K.3
  • 14
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent endpoints
    • Reed L, Meunch H. A simple method of estimating fifty percent endpoints. Am J Hygiene 1838;27:493-497.
    • (1838) Am J Hygiene , vol.27 , pp. 493-497
    • Reed, L.1    Meunch, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.