Ion pairing with bile salts modulates intestinal permeability and contributes to food-drug interaction of BCS class III compound trospium chloride

Molecular Pharmaceutics

Volumn 10, Issue 11, 2013, Pages 3989-3996

  Heinen, Christian A ^a   Reuss, Stefan ^a   Amidon, Gordon L ^b   Langguth, Peter ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

bile; ion pairing; negative food effect; rat; trospium chloride; Ussing chamber

Indexed keywords

BILE SALT; GLYCOCHENODEOXYCHOLIC ACID; OLIVE OIL; TAUROCHENODEOXYCHOLIC ACID; TAURODEOXYCHOLIC ACID; TROSPIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; EMULSION; FAT INTAKE; FOOD DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE MUCOSA PERMEABILITY; ISOTHERMAL TITRATION CALORIMETRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; BENZILATES; BILE ACIDS AND SALTS; CACO-2 CELLS; CATTLE; FOOD-DRUG INTERACTIONS; GLYCOCHENODEOXYCHOLIC ACID; HUMANS; INTESTINAL ABSORPTION; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NORTROPANES; RATS; RATS, WISTAR; TAURODEOXYCHOLIC ACID;

EID: 84887381890     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400179v     Document Type: Article

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