Determination of the quaternary ammonium compound trospium in human plasma by LC-MS/MS: Application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 13-14, 2010, Pages 981-986

  Hotha, Kishore Kumar ^a,b   Bharathi, D Vijaya ^a   Kumar, Sanagapati Sirish ^a   Reddy, Y Narasimha ^a   Chatki, Pankaj K ^a   Ravindranath, L K ^c   Jayaveera, K N ^b  

^a DR REDDY'S LABORATORIES LTD   (India)

^b JNT University   (India)

^c SRI KRISHNADEVARAYA UNIVERSITY   (India)

Author keywords

Human plasma; LC MS MS; Pharmacokinetics; Quaternary compound; Trospium

Indexed keywords

ANALYTES; ASSAY METHODS; FREEZE/THAW CYCLES; HIGHLY SENSITIVE; HUMAN PLASMAS; INTERNAL STANDARDS; ISOCRATIC MOBILE PHASE; LC-MS/MS; LINEAR RESPONSE FUNCTIONS; LOWER LIMIT OF QUANTIFICATIONS; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC STUDIES; QUATERNARY AMMONIUM COMPOUND; QUATERNARY COMPOUND; REVERSE-PHASE COLUMN; RUNTIMES; SPE EXTRACTION; STABILITY STUDY;

AMMONIUM COMPOUNDS; PHARMACOKINETICS; PLASMA (HUMAN);

PLASMAS;

QUATERNARY AMMONIUM DERIVATIVE; TROSPIUM CHLORIDE;

ARTICLE; ELUTION; FREEZE DRYING; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; THAWING;

CHROMATOGRAPHY, LIQUID; LIMIT OF DETECTION; NORTROPANES; QUATERNARY AMMONIUM COMPOUNDS; TANDEM MASS SPECTROMETRY;

EID: 77950216475     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.02.028     Document Type: Article

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