Increased affinity to canalicular P-gp via formation of lipophilic ion-pair complexes with endogenous bile salts is associated with mw threshold in hepatobiliary excretion of quaternary ammonium compounds

Pharmaceutical Research

Volumn 27, Issue 5, 2010, Pages 823-831

  Song, Im Sook ^a   Choi, Min Koo ^b   Jin, Qing Ri ^b   Shim, Won Sik ^b   Shim, Chang Koo ^b  

^a Inje University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Hepato biliary excretion; Ion pair complex; Molecular weight threshold; P gp

Indexed keywords

BILE SALT; DAUNORUBICIN; GLYCOPROTEIN P; OCTANOL; ORGANIC CATION TRANSPORTER 1; PHOSPHATE; QUATERNARY AMMONIUM DERIVATIVE; TAURODEOXYCHOLIC ACID;

ANIMAL CELL; ARTICLE; BILIARY EXCRETION; CELL STRAIN; COMPLEX FORMATION; CONTROLLED STUDY; HEPATOBILIARY SYSTEM; MOLECULAR WEIGHT; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTEIN BINDING; RAT; WESTERN BLOTTING;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; BILE; BILE ACIDS AND SALTS; BILE CANALICULI; BIOLOGICAL TRANSPORT, ACTIVE; BLOTTING, WESTERN; CATECHOLAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; CELL LINE; DATA INTERPRETATION, STATISTICAL; DAUNORUBICIN; DOGS; LIPIDS; LIVER; MOLECULAR WEIGHT; P-GLYCOPROTEIN; QUATERNARY AMMONIUM COMPOUNDS; RATS; SOLUBILITY; TAURODEOXYCHOLIC ACID;

EID: 77953290975     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0075-0     Document Type: Article

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