Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 781-788

  Redondo, Miriam ^a   Soteras, Ignacio ^a   Brea, José ^b   González García, Alejandro ^b   Cadavid, María Isabel ^b   Loza, María Isabel ^b   Martinez, Ana ^a   Gil, Carmen ^a   Campillo, Nuria E ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Allosteric sites; Docking; Neurodegeneration; PDE7; Surface study

Indexed keywords

PHOSPHODIESTERASE VII; PHOSPHODIESTERASE VII INHIBITOR;

ALLOSTERISM; ARTICLE; BINDING SITE; CARDIOTOXICITY; CRYSTAL STRUCTURE; DRUG BINDING SITE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; MOLECULAR DOCKING; SURFACE PROPERTY; VOMITING;

ALLOSTERIC SITES; DOCKING; NEURODEGENERATION; PDE7; SURFACE STUDY;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 7; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

EID: 84887371622     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.035     Document Type: Article

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