Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: First phosphodiesterase 7 inhibitors

Journal of Medicinal Chemistry

Volumn 43, Issue 4, 2000, Pages 683-689

  Martínez, Ana ^a   Castro, Ana ^a   Gil, Carmen ^a   Miralpeix, Montserrat ^b   Segarra, Victor ^b   Doménech, Teresa ^b   Beleta, Jorge ^b   Palacios, Jose M ^b   Ryder, Hamish ^b   Miró, Xavier ^c   Bonet, Carles ^c   Casacuberta, Josep M ^c   Azorín, Ferran ^c   Piña, Benjamí ^c   Puigdoménech, Pere ^c  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b Almirall Prodesfarma SA ^*  (Spain)

^c INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(3,4 DICHLOROPHENYL)METHYL] 2,1,3 BENZOTHIADIAZIN 4(3H) ONE 2,2 DIOXIDE; 1 [(4 DIPHENYL)CARBONYLMETHYL]BENZOTHIENO[3,2 A] 1,2,6 THIADIAZIN 4(3H) ONE 2,2 DIOXIDE; 1 [(4 METHOXYPHENYL)CARBONYLMETHYL]BENZOTHIENO[3,2 A] 1,2,6 THIADIAZIN 4(3H) ONE 2,2 DIOXIDE; BENZYL DERIVATIVE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; BENZOTHIADIAZINES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; ISOENZYMES; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZINES;

EID: 0343986277     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990382n     Document Type: Article

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