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Volumn , Issue , 2013, Pages 1-31

ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling

Author keywords

Chemical prioritization; Computational modeling; Computational toxicology; High throughput screening; In vitro assays

Indexed keywords


EID: 84887236218     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118538203.ch1     Document Type: Chapter
Times cited : (9)

References (58)
  • 1
    • 67650445156 scopus 로고    scopus 로고
    • Toxicology for the twenty-first century
    • Hartung, T. (2009). Toxicology for the twenty-first century. Nature, 460, 208-212.
    • (2009) Nature , vol.460 , pp. 208-212
    • Hartung, T.1
  • 8
    • 79959471969 scopus 로고    scopus 로고
    • BioAssay Ontology (BAO): A semantic description of bioassays and high-throughput screening results
    • Visser, U., Abeyruwan, S., Vempati, U., Smith, R.P., Lemmon, V., Scḧurer, S.C. (2011). BioAssay Ontology (BAO): A semantic description of bioassays and high-throughput screening results. BMC Bioinformatics, 12, 257.
    • (2011) BMC Bioinformatics , vol.12 , pp. 257
    • Visser, U.1    Abeyruwan, S.2    Vempati, U.3    Smith, R.P.4    Lemmon, V.5    Scḧurer, S.C.6
  • 9
    • 39349118236 scopus 로고    scopus 로고
    • Toxicology: Transforming environmental health protection
    • Collins, F.S., Gray, G.M., Bucher, J.R. (2008). Toxicology: Transforming environmental health protection. Science, 319, 906-907.
    • (2008) Science , vol.319 , pp. 906-907
    • Collins, F.S.1    Gray, G.M.2    Bucher, J.R.3
  • 10
    • 62749084516 scopus 로고    scopus 로고
    • Toxicity testing in the 21st Century: Implications for human health risk assessment
    • Kavlock, R.J., Austin, C.P., Tice, R.R. (2009). Toxicity testing in the 21st Century: Implications for human health risk assessment. Risk Analysis, 29, 485-487.
    • (2009) Risk Analysis , vol.29 , pp. 485-487
    • Kavlock, R.J.1    Austin, C.P.2    Tice, R.R.3
  • 12
    • 40049100210 scopus 로고    scopus 로고
    • Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure
    • Bender, A., Scheiber, J., Glick, M., Davies, J.W., Azzaoui, K., Hamon, J., Urban, L., Whitebread, S., Jenkins, J.L. (2007). Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure. ChemMedChem, 2, 861-873.
    • (2007) ChemMedChem , vol.2 , pp. 861-873
    • Bender, A.1    Scheiber, J.2    Glick, M.3    Davies, J.W.4    Azzaoui, K.5    Hamon, J.6    Urban, L.7    Whitebread, S.8    Jenkins, J.L.9
  • 13
    • 84887230346 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. Accessed May 4, 2012
    • U.S. Food and Drug Administration. (1999). Guidance for industry: Antimicrobial food additives. Available at http://www.fda.gov/Food/GuidanceComplianceRegulatory Information/GuidanceDocuments/FoodIngredientsandPackaging/ucm077256.htm. Accessed May 4, 2012.
    • (1999) Guidance for industry: Antimicrobial food additives
  • 14
    • 84880398277 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency. Accessed May 4, 2012
    • U.S. Environmental Protection Agency. (2012). Data requirements for pesticide registration. Available at http://www.epa.gov/pesticides/regulating/data requirements.htm. Accessed May 4, 2012.
    • (2012) Data requirements for pesticide registration
  • 15
    • 33845311498 scopus 로고    scopus 로고
    • Unidentified inert ingredients in pesticides: Implications for human and environmental health
    • Cox, C., Surgan, M. (2006). Unidentified inert ingredients in pesticides: Implications for human and environmental health. Environmental Health Perspectives, 114, 1803-1806.
    • (2006) Environmental Health Perspectives , vol.114 , pp. 1803-1806
    • Cox, C.1    Surgan, M.2
  • 17
    • 84887231126 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. CFSAN: Scope of responsibility. Accessed May 22, 2012
    • U.S. Food and Drug Administration. CFSAN: Scope of responsibility. Available at http:// www.fda.gov/AboutFDA/CentersOffices/OfficeofFoods/CFSAN/WhatWeDo/default .htm. Accessed May 22, 2012.
  • 20
    • 79955428497 scopus 로고    scopus 로고
    • The NCGC pharmaceutical collection: A comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics
    • Huang, R., Southall, N.,Wang, Y., Yasgar, A., Shinn, P., Jadhav, A., Nguyen, D.T., Austin, C.P. (2011). The NCGC pharmaceutical collection: A comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Science Translational Medicine, 3, 80ps16.
    • (2011) Science Translational Medicine , vol.3 , Issue.80
    • Huang, R.1    Southall, N.2    Wang, Y.3    Yasgar, A.4    Shinn, P.5    Jadhav, A.6    Nguyen, D.T.7    Austin, C.P.8
  • 21
    • 33746742909 scopus 로고    scopus 로고
    • Looking towards label-free biomolecular interaction analysis in a high-throughput format: A review of new surface plasmon resonance technologies
    • Boozer, C., Kim, G., Cong, S., Guan, H., Londergan, T. (2006). Looking towards label-free biomolecular interaction analysis in a high-throughput format: A review of new surface plasmon resonance technologies. Current Opinion in Biotechnology, 17, 400-405.
    • (2006) Current Opinion in Biotechnology , vol.17 , pp. 400-405
    • Boozer, C.1    Kim, G.2    Cong, S.3    Guan, H.4    Londergan, T.5
  • 22
    • 0029761822 scopus 로고    scopus 로고
    • HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine
    • Roy, M., Dumaine, R., Brown, A.M. (1996). HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation, 94, 817-823.
    • (1996) Circulation , vol.94 , pp. 817-823
    • Roy, M.1    Dumaine, R.2    Brown, A.M.3
  • 24
    • 0034973773 scopus 로고    scopus 로고
    • Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
    • Guengerich, F.P. (2001). Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chemical Research in Toxicology, 14, 611-650.
    • (2001) Chemical Research in Toxicology , vol.14 , pp. 611-650
    • Guengerich, F.P.1
  • 25
    • 43149118341 scopus 로고    scopus 로고
    • The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox)
    • Szakács, G., Váradi, A., Özvegy-Laczka, C., Sarkadi, B. (2008). The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). Drug Discovery Today, 13, 379-393.
    • (2008) Drug Discovery Today , vol.13 , pp. 379-393
    • Szakács, G.1    Váradi, A.2    Özvegy-Laczka, C.3    Sarkadi, B.4
  • 26
    • 0032779083 scopus 로고    scopus 로고
    • Teratology Society Public Affairs Committee position paper: Developmental toxicity of endocrine disruptors to humans
    • Barlow, S., Kavlock, R.J., Moore, J.A., Schantz, S.L., Sheehan, D.M., Shuey, D.L., Lary, J.M. (1999). Teratology Society Public Affairs Committee position paper: Developmental toxicity of endocrine disruptors to humans. Teratology, 60, 365-375.
    • (1999) Teratology , vol.60 , pp. 365-375
    • Barlow, S.1    Kavlock, R.J.2    Moore, J.A.3    Schantz, S.L.4    Sheehan, D.M.5    Shuey, D.L.6    Lary, J.M.7
  • 29
    • 21744434042 scopus 로고    scopus 로고
    • Multiplexed high content screening assays create a systems cell biology approach to drug discovery
    • Taylor, D.L., Giuliano, K.A. (2005). Multiplexed high content screening assays create a systems cell biology approach to drug discovery. Drug Discovery Today, 2, 149-154.
    • (2005) Drug Discovery Today , vol.2 , pp. 149-154
    • Taylor, D.L.1    Giuliano, K.A.2
  • 30
    • 67349242950 scopus 로고    scopus 로고
    • Multiplexed quantitative high content screening reveals that cigarette smoke condensate induces changes in cell structure and function through alterations in cell signaling pathways in human bronchial cells
    • Cartera, C.A., Hamm, J.T. (2009). Multiplexed quantitative high content screening reveals that cigarette smoke condensate induces changes in cell structure and function through alterations in cell signaling pathways in human bronchial cells. Toxicology, 261, 89-102.
    • (2009) Toxicology , vol.261 , pp. 89-102
    • Cartera, C.A.1    Hamm, J.T.2
  • 32
    • 78049403279 scopus 로고    scopus 로고
    • Ligand binding assays at equilibrium: Validation and interpretation
    • Hulme, E.C., Trevethick, M.A. (2010). Ligand binding assays at equilibrium: Validation and interpretation. British Journal of Pharmacology, 161, 1219-1237.
    • (2010) British Journal of Pharmacology , vol.161 , pp. 1219-1237
    • Hulme, E.C.1    Trevethick, M.A.2
  • 38
    • 0003043542 scopus 로고
    • The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves
    • Hill, A.V. (1910). The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. Journal of Physiology, 40, 4-7.
    • (1910) Journal of Physiology , vol.40 , pp. 4-7
    • Hill, A.V.1
  • 42
    • 0034010667 scopus 로고    scopus 로고
    • Threshold of toxicological concern for chemical substances present in the diet: A practical tool for assessing the need for toxicity testing
    • Kroesa, R., Gallib, C., Munroc, I., Schilterd, B., Trane, L.-A., Walkerf, R., Ẅurtzeng, G. (2000). Threshold of toxicological concern for chemical substances present in the diet: A practical tool for assessing the need for toxicity testing. Food and Chemical Toxicology, 38, 255-312.
    • (2000) Food and Chemical Toxicology , vol.38 , pp. 255-312
    • Kroesa, R.1    Gallib, C.2    Munroc, I.3    Schilterd, B.4    Trane, L.-A.5    Walkerf, R.6    Ẅurtzeng, G.7
  • 49
    • 0037253774 scopus 로고    scopus 로고
    • EGF and TGF-alpha expression influence the developmental toxicity of TCDD: Dose response and AhR phenotype in EGF, TGF-alpha, and EGF + TGF-alpha knockout mice
    • Abbott, B.D., Buckalew, A.R., DeVito, M.J., Ross, D., Bryant, P.L., Schmid, J.E. (2003). EGF and TGF-alpha expression influence the developmental toxicity of TCDD: Dose response and AhR phenotype in EGF, TGF-alpha, and EGF + TGF-alpha knockout mice. Toxicological Sciences, 71, 84-95.
    • (2003) Toxicological Sciences , vol.71 , pp. 84-95
    • Abbott, B.D.1    Buckalew, A.R.2    DeVito, M.J.3    Ross, D.4    Bryant, P.L.5    Schmid, J.E.6
  • 50
    • 0032957695 scopus 로고    scopus 로고
    • Ah receptor and NFkappa B interactions, a potential mechanism for dioxin toxicity
    • Tian, Y., Ke, S., Denison, M.S., Rabson, A.B., Gallo, M.A. (1999). Ah receptor and NFkappa B interactions, a potential mechanism for dioxin toxicity. Journal of Biological Chemistry, 274, 510-515.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 510-515
    • Tian, Y.1    Ke, S.2    Denison, M.S.3    Rabson, A.B.4    Gallo, M.A.5
  • 51
    • 59349114674 scopus 로고    scopus 로고
    • Ah receptor and NF-kappa B interplay on the stage of epigenome
    • Tian, Y.A. (2009). Ah receptor and NF-kappa B interplay on the stage of epigenome. Biochemical Pharmacology, 77, 670-680.
    • (2009) Biochemical Pharmacology , vol.77 , pp. 670-680
    • Tian, Y.A.1
  • 52
    • 0037145026 scopus 로고    scopus 로고
    • Ah receptor and NF-kappa B interactions: Mechanisms and physiological implications
    • Tian, Y.N., Rabson, A.B., Gallo, M. A. (2002). Ah receptor and NF-kappa B interactions: Mechanisms and physiological implications. Chemico-Biological Interactions, 141, 97-115.
    • (2002) Chemico-Biological Interactions , vol.141 , pp. 97-115
    • Tian, Y.N.1    Rabson, A.B.2    Gallo, M.A.3
  • 53
    • 77954130868 scopus 로고    scopus 로고
    • A theory of chemicals testing and regulation
    • Gabbert, S., Weikard, H.P. (2010). A theory of chemicals testing and regulation. Natural Resources Forum, 34, 155-164.
    • (2010) Natural Resources Forum , vol.34 , pp. 155-164
    • Gabbert, S.1    Weikard, H.P.2
  • 56
    • 0347753697 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptors and cancers: Complex stories
    • Michalik, L., Desvergne, B., Wahli, W. (2004). Peroxisome-proliferator-activated receptors and cancers: Complex stories. Nature Reviews Cancer, 4, 61-70.
    • (2004) Nature Reviews Cancer , vol.4 , pp. 61-70
    • Michalik, L.1    Desvergne, B.2    Wahli, W.3
  • 58
    • 77954612559 scopus 로고    scopus 로고
    • Simulating microdosimetry in a virtual hepatic lobule
    • Wambaugh, J., Imran, S. (2010). Simulating microdosimetry in a virtual hepatic lobule. PLoS Computational Biology, 6(4), e1000756.
    • (2010) PLoS Computational Biology , vol.6 , Issue.4
    • Wambaugh, J.1    Imran, S.2


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