Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 6, 2011, Pages 1424-1431

  Brea, David ^a   Blanco, Miguel ^a   Ramos Cabrer, Pedro ^a   Moldes, Octavio ^a   Arias, Susana ^a   Pérez Mato, María ^a   Leira, Rogelio ^a   Sobrino, Tomás ^a   Castillo, José ^a  

^a University Hospital of Santiago de Compostela   (Spain)

Author keywords

brain ischemia; endogenous ligands; inflammation; outcome; Toll like receptors

Indexed keywords

ANTITHROMBOCYTIC AGENT; C REACTIVE PROTEIN; FIBRONECTIN; HEAT SHOCK PROTEIN 60; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

AGED; ANTICOAGULANT THERAPY; ARTICLE; BRAIN ISCHEMIA; DISEASE ASSOCIATION; FEMALE; HEART ATRIUM FIBRILLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TREATMENT OUTCOME; UMBILICAL VEIN ENDOTHELIAL CELL;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CELL LINE; CELLS, CULTURED; CHAPERONIN 60; FEMALE; FIBRONECTINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LIGANDS; MALE; MIDDLE AGED; MONOCYTES; STROKE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 79957938359     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.231     Document Type: Article

References (21)

1. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE, III (1993) Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24:35-41 (Pubitemid 23014379)
2. Adams Jr HP, Davis PH, Leira EC, Chang KC, Bendixen BH, Clarke WR, Woolson RF, Hansen MD (1999) Baseline NIH Stroke Scale score strongly predicts outcome after stroke: a report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology 53:126-31 (Pubitemid 29329660)
3. Akira S (2006) TLR signaling. Curr Top Microbiol Immunol 311:1-16 (Pubitemid 47413193)
4. Cao CX, Yang QW, Lv FL, Cui J, Fu HB, Wang JZ (2007) Reduced cerebral ischemia-reperfusion injury in Tolllike receptor 4 deficient mice. Biochem Biophys Res Commun 353:509-14 (Pubitemid 46023466)
5. Caso JR, Pradillo JM, Hurtado O, Leza JC, Moro MA, Lizasoain I (2008) Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke. Stroke 39:1314-20 (Pubitemid 351440707)
6. Chapman KZ, Dale VQ, Denes A, Bennett G, Rothwell NJ, Allan SM, McColl BW (2009) A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke. J Cereb Blood Flow Metab 29:1764-8
7. Damas JK, Jensenius M, Ueland T, Otterdal K, Yndestad A, Froland SS, Rolain JM, Myrvang B, Raoult D, Aukrust P (2006) Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. J Immunol 177: 2699-706 (Pubitemid 44201029)
8. Fischer S, Nishio M, Peters SC, Tschernatsch M, Walberer M, Weidemann S, Heidenreich R, Couraud PO, Weksler BB, Romero IA, Gerriets T, Preissner KT (2009) Signaling mechanism of extracellular RNA in endothelial cells. FASEB J 23:2100-9
9. Goos M, Lange P, Hanisch UK, Prinz M, Scheffel J, Bergmann R, Ebert S, Nau R (2007) Fibronectin is elevated in the cerebrospinal fluid of patients suffering from bacterial meningitis and enhances inflammation caused by bacterial products in primary mouse micro-glial cell cultures. J Neurochem 102:2049-60 (Pubitemid 47329276)
10. Hua F, Ma J, Ha T, Kelley JL, Kao RL, Schweitzer JB, Kalbfleisch JH, Williams DL, Li C (2009) Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice. Brain Res 1262:100-8
11. Kamgang RK, Ramos I, Rodrigues Duarte L, Ghielmetti M, Freudenberg M, Dahinden C, Padovan E (2008) Using distinct molecular signatures of human monocytes and dendritic cells to predict adjuvant activity and pyro-genicity of TLR agonists. Med Microbiol Immunol 197:369-79
12. Kariko K, Ni H, Capodici J, Lamphier M, Weissman D (2004) mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 279:12542-50 (Pubitemid 38445825)
13. Kikkert R, de Groot ER, Aarden LA (2008) Cytokine induction by pyrogens: comparison of whole blood, mononuclear cells, and TLR-transfectants. J Immunol Methods 336:45-55
14. Lasarte JJ, Casares N, Gorraiz M, Hervas-Stubbs S, Arribillaga L, Mansilla C, Durantez M, Llopiz D, Sarobe P, Borras-Cuesta F, Prieto J, Leclerc C (2007) The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo. J Immunol 178:748-56 (Pubitemid 46098855)
15. Lehnardt S, Lehmann S, Kaul D, Tschimmel K, Hoffmann O, Cho S, Krueger C, Nitsch R, Meisel A, Weber JR (2007) Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia. J Neuroimmunol 190:28-33 (Pubitemid 47625604)
16. Lin YC, Chang YM, Yu JM, Yen JH, Chang JG, Hu CJ (2005) Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan. Atherosclerosis 180:305-9
17. Methe H, Kim JO, Kofler S, Weis M, Nabauer M, Koglin J (2005) Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome. Circulation 111:2654-61 (Pubitemid 40740866)
18. Offner H, Subramanian S, Parker SM, Afentoulis ME, Vandenbark AA, Hurn PD (2006) Experimental stroke induces massive, rapid activation of the peripheral immune system. J Cereb Blood Flow Metab 26:654-65
19. Sims JR, Gharai LR, Schaefer PW, Vangel M, Rosenthal ES, Lev MH, Schwamm LH (2009) ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes. Neurology 72:2104-10
20. Urra X, Cervera A, Obach V, Climent N, Planas AM, Chamorro A (2009) Monocytes are major players in the prognosis and risk of infection after acute stroke. Stroke 40:1262-8
21. Yang QW, Li JC, Lu FL, Wen AQ, Xiang J, Zhang LL, Huang ZY, Wang JZ (2008) Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction. J Cereb Blood Flow Metab 28:1588-96