-
1
-
-
0032580354
-
Drug delivery and targeting
-
Langer, R. (1998) Drug delivery and targeting. Nature, 392 (Suppl. 6679), 5-10.
-
(1998)
Nature
, vol.392
, Issue.SUPPL. 6679
, pp. 5-10
-
-
Langer, R.1
-
2
-
-
14644439267
-
Cancer nanotechnology: opportunities and challenges
-
Ferrari, M. (2005) Cancer nanotechnology: opportunities and challenges. Nat. Rev. Cancer, 5, 161-171.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 161-171
-
-
Ferrari, M.1
-
3
-
-
51049090204
-
Nanoparticle therapeutics: an emerging treatment modality for cancer
-
Davis, M.E., Chen, Z.G., and Shin, D.M. (2008) Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov., 7, 771-782.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 771-782
-
-
Davis, M.E.1
Chen, Z.G.2
Shin, D.M.3
-
4
-
-
0033199028
-
Pretargeting of renal cell carcinoma: improved tumor targeting with a bivalent chelate
-
Boerman, O.C. et al. (1999) Pretargeting of renal cell carcinoma: improved tumor targeting with a bivalent chelate. Cancer Res., 59, 4400-4405.
-
(1999)
Cancer Res.
, vol.59
, pp. 4400-4405
-
-
Boerman, O.C.1
-
5
-
-
0032916670
-
Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin
-
Paganelli, G. et al. (1999) Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin. Eur. J. Nucl. Med., 26, 348-357.
-
(1999)
Eur. J. Nucl. Med.
, vol.26
, pp. 348-357
-
-
Paganelli, G.1
-
6
-
-
12944301124
-
Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity
-
Axworthy, D.B. et al. (2000) Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity. Proc. Natl. Acad. Sci. USA, 97, 1802-1807.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 1802-1807
-
-
Axworthy, D.B.1
-
7
-
-
0033506131
-
Generating improved single-chain Fv molecules for tumor targeting
-
Adams, G.P. and Schier, R. (1999) Generating improved single-chain Fv molecules for tumor targeting. J. Immunol. Methods, 231, 249-260.
-
(1999)
J. Immunol. Methods
, vol.231
, pp. 249-260
-
-
Adams, G.P.1
Schier, R.2
-
8
-
-
0029918942
-
Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers
-
Wu, A.M. et al. (1996) Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers. Immunotechnology, 2, 21-36.
-
(1996)
Immunotechnology
, vol.2
, pp. 21-36
-
-
Wu, A.M.1
-
9
-
-
57549090074
-
HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy
-
Alexis, F. et al. (2008) HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy. ChemMedChem, 3, 1839-1843.
-
(2008)
ChemMedChem
, vol.3
, pp. 1839-1843
-
-
Alexis, F.1
-
10
-
-
33646582037
-
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
-
Farokhzad, O.C. et al. (2006) Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc. Natl. Acad. Sci. USA, 103, 6315-6320.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 6315-6320
-
-
Farokhzad, O.C.1
-
11
-
-
7444223607
-
Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells
-
Farokhzad, O.C. et al. (2004) Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res., 64, 7668-7672.
-
(2004)
Cancer Res.
, vol.64
, pp. 7668-7672
-
-
Farokhzad, O.C.1
-
12
-
-
33646851877
-
Nanoparticle-aptamer bioconjugates for cancer targeting
-
Farokhzad, O.C., Karp, J.M., and Langer, R. (2006) Nanoparticle-aptamer bioconjugates for cancer targeting. Expert Opin. Drug Deliv., 3, 311-324.
-
(2006)
Expert Opin. Drug Deliv.
, vol.3
, pp. 311-324
-
-
Farokhzad, O.C.1
Karp, J.M.2
Langer, R.3
-
13
-
-
36849067019
-
Nanocarriers as an emerging platform for cancer therapy
-
Peer, D. et al. (2007) Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol., 2, 751-760.
-
(2007)
Nat. Nanotechnol.
, vol.2
, pp. 751-760
-
-
Peer, D.1
-
14
-
-
54049111463
-
Nanotechnology for drug delivery: the perfect partnership
-
Farokhzad, O.C. (2008) Nanotechnology for drug delivery: the perfect partnership. Expert Opin. Drug Deliv., 5, 927-929.
-
(2008)
Expert Opin. Drug Deliv.
, vol.5
, pp. 927-929
-
-
Farokhzad, O.C.1
-
15
-
-
33748930410
-
Drug delivery systems in urology - getting ''smarter''
-
Farokhzad, O.C. et al. (2006) Drug delivery systems in urology - getting ''smarter''. Urology, 68, 463-469.
-
(2006)
Urology
, vol.68
, pp. 463-469
-
-
Farokhzad, O.C.1
-
16
-
-
33751419875
-
Nanomedicine: developing smarter therapeutic and diagnostic modalities
-
Farokhzad, O.C. and Langer, R. (2006) Nanomedicine: developing smarter therapeutic and diagnostic modalities. Adv. Drug Deliv. Rev., 58, 1456-1459.
-
(2006)
Adv. Drug Deliv. Rev.
, vol.58
, pp. 1456-1459
-
-
Farokhzad, O.C.1
Langer, R.2
-
17
-
-
61849153021
-
Impact of nanotechnology on drug delivery
-
Farokhzad, O.C. and Langer, R. (2009) Impact of nanotechnology on drug delivery. ACS Nano, 3, 16-20.
-
(2009)
ACS Nano
, vol.3
, pp. 16-20
-
-
Farokhzad, O.C.1
Langer, R.2
-
18
-
-
77955128541
-
Aptamers as therapeutics
-
Keefe, A.D., Pai, S., and Ellington, A. (2010) Aptamers as therapeutics. Nat. Rev. Drug Discov., 9, 537-550.
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 537-550
-
-
Keefe, A.D.1
Pai, S.2
Ellington, A.3
-
19
-
-
0029876415
-
Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2
-
Colas, P. et al. (1996) Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2. Nature, 380, 548-550.
-
(1996)
Nature
, vol.380
, pp. 548-550
-
-
Colas, P.1
-
20
-
-
34147125167
-
Selection and characterization of large collections of peptide aptamers through optimized yeast two-hybrid procedures
-
Bickle, M.B., Dusserre, E., Moncorge, O., Bottin, H., and Colas, P. (2006) Selection and characterization of large collections of peptide aptamers through optimized yeast two-hybrid procedures. Nat. Protoc., 1, 1066-1091.
-
(2006)
Nat. Protoc.
, vol.1
, pp. 1066-1091
-
-
Bickle, M.B.1
Dusserre, E.2
Moncorge, O.3
Bottin, H.4
Colas, P.5
-
21
-
-
41149117550
-
The eleven-year switch of peptide aptamers
-
Colas, P. (2008) The eleven-year switch of peptide aptamers. J. Biol., 7, 2.
-
(2008)
J. Biol.
, vol.7
, pp. 2
-
-
Colas, P.1
-
22
-
-
33645875308
-
Peptide aptamers as guides for small-molecule drug discovery
-
Baines, I.C. and Colas, P. (2006) Peptide aptamers as guides for small-molecule drug discovery. Drug Discov. Today, 11, 334-341.
-
(2006)
Drug Discov. Today
, vol.11
, pp. 334-341
-
-
Baines, I.C.1
Colas, P.2
-
23
-
-
0025074907
-
In vitro selection of RNA molecules that bind specific ligands
-
Ellington, A.D. and Szostak, J.W. (1990) In vitro selection of RNA molecules that bind specific ligands. Nature, 346, 818-822.
-
(1990)
Nature
, vol.346
, pp. 818-822
-
-
Ellington, A.D.1
Szostak, J.W.2
-
24
-
-
0025194307
-
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
-
Tuerk, C. and Gold, L. (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science, 249, 505-510.
-
(1990)
Science
, vol.249
, pp. 505-510
-
-
Tuerk, C.1
Gold, L.2
-
25
-
-
77649103704
-
Discovery and development of therapeutic aptamers
-
Bouchard, P.R., Hutabarat, R.M., and Thompson, K.M. (2010) Discovery and development of therapeutic aptamers. Annu. Rev. Pharmacol. Toxicol., 50, 237-257.
-
(2010)
Annu. Rev. Pharmacol. Toxicol.
, vol.50
, pp. 237-257
-
-
Bouchard, P.R.1
Hutabarat, R.M.2
Thompson, K.M.3
-
26
-
-
70349786346
-
The chemical biology of aptamers
-
Mayer, G. (2009) The chemical biology of aptamers. Angew. Chem. Int. Ed. Engl., 48, 2672-2689.
-
(2009)
Angew. Chem. Int. Ed. Engl.
, vol.48
, pp. 2672-2689
-
-
Mayer, G.1
-
27
-
-
33845723241
-
An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform
-
Bagalkot, V., Farokhzad, O.C., Langer, R., and Jon, S. (2006) An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew. Chem. Int. Ed., 45, 8149-8152.
-
(2006)
Angew. Chem. Int. Ed.
, vol.45
, pp. 8149-8152
-
-
Bagalkot, V.1
Farokhzad, O.C.2
Langer, R.3
Jon, S.4
-
28
-
-
36248973801
-
Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer
-
Bagalkot, V. et al. (2007) Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer. Nano Lett., 7, 3065-3070.
-
(2007)
Nano Lett.
, vol.7
, pp. 3065-3070
-
-
Bagalkot, V.1
-
29
-
-
57349179892
-
Aptamer-based endocytosis of a lysosomal enzyme
-
Chen, C.H. et al. (2008) Aptamer-based endocytosis of a lysosomal enzyme. Proc. Natl. Acad. Sci. USA, 105, 15908-15913.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 15908-15913
-
-
Chen, C.H.1
-
30
-
-
33745714275
-
Aptamer:toxin conjugates that specifically target prostate tumor cells
-
Chu, T.C. et al. (2006) Aptamer:toxin conjugates that specifically target prostate tumor cells. Cancer Res., 66, 5989-5992.
-
(2006)
Cancer Res.
, vol.66
, pp. 5989-5992
-
-
Chu, T.C.1
-
31
-
-
33745128099
-
Aptamer mediated siRNA delivery
-
Chu, T.C., Twu, K.Y., Ellington, A.D., and Levy, M. (2006) Aptamer mediated siRNA delivery. Nucleic Acids Res., 34, e73.
-
(2006)
Nucleic Acids Res.
, vol.34
-
-
Chu, T.C.1
Twu, K.Y.2
Ellington, A.D.3
Levy, M.4
-
32
-
-
33747031960
-
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
-
McNamara, J.O. II et al. (2006) Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat. Biotechnol., 24, 1005-1015.
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 1005-1015
-
-
McNamara, J.O.1
-
33
-
-
31044432108
-
Correlation between PSMA and VEGF expression as markers for LNCaP tumor angiogenesis
-
Tsui, P., Rubenstein, M., and Guinan, P. (2005) Correlation between PSMA and VEGF expression as markers for LNCaP tumor angiogenesis. J. Biomed. Biotechnol., 2005, 287-290.
-
(2005)
J. Biomed. Biotechnol.
, vol.2005
, pp. 287-290
-
-
Tsui, P.1
Rubenstein, M.2
Guinan, P.3
-
34
-
-
0034797419
-
A unique folate hydrolase, prostate-specific membrane antigen (PSMA): a target for immunotherapy?
-
Tasch, J., Gong, M., Sadelain, M., and Heston, W.D. (2001) A unique folate hydrolase, prostate-specific membrane antigen (PSMA): a target for immunotherapy? Crit. Rev. Immunol., 21, 249-261.
-
(2001)
Crit. Rev. Immunol.
, vol.21
, pp. 249-261
-
-
Tasch, J.1
Gong, M.2
Sadelain, M.3
Heston, W.D.4
-
35
-
-
0032530135
-
Constitutive and antibody-induced internalization of prostate-specific membrane antigen
-
Liu, H. et al. (1998) Constitutive and antibody-induced internalization of prostate-specific membrane antigen. Cancer Res., 58, 4055-4060.
-
(1998)
Cancer Res.
, vol.58
, pp. 4055-4060
-
-
Liu, H.1
-
36
-
-
0037099536
-
Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen
-
Lupold, S.E., Hicke, B.J., Lin, Y., and Coffey, D.S. (2002) Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen. Cancer Res., 62, 4029-4033.
-
(2002)
Cancer Res.
, vol.62
, pp. 4029-4033
-
-
Lupold, S.E.1
Hicke, B.J.2
Lin, Y.3
Coffey, D.S.4
-
37
-
-
47049115502
-
Nanotechnology and aptamers: applications in drug delivery
-
Levy-Nissenbaum, E., Radovic-Moreno, A.F., Wang, A.Z., Langer, R., and Farokhzad, O.C. (2008) Nanotechnology and aptamers: applications in drug delivery. Trends Biotechnol., 26, 442-449.
-
(2008)
Trends Biotechnol.
, vol.26
, pp. 442-449
-
-
Levy-Nissenbaum, E.1
Radovic-Moreno, A.F.2
Wang, A.Z.3
Langer, R.4
Farokhzad, O.C.5
-
38
-
-
67650477343
-
Aptamers and aptamer targeted delivery
-
Yan, A.C. and Levy, M. (2009) Aptamers and aptamer targeted delivery. RNA Biol., 6, 316-320.
-
(2009)
RNA Biol.
, vol.6
, pp. 316-320
-
-
Yan, A.C.1
Levy, M.2
-
39
-
-
70349272617
-
Therapeutic applications of DNA and RNA aptamers
-
Thiel, K.W. and Giangrande, P.H. (2009) Therapeutic applications of DNA and RNA aptamers. Oligonucleotides, 19, 209-222.
-
(2009)
Oligonucleotides
, vol.19
, pp. 209-222
-
-
Thiel, K.W.1
Giangrande, P.H.2
-
40
-
-
0032081316
-
Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T lymphocyte function
-
Kraus, E., James, W., and Barclay, A.N. (1998) Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T lymphocyte function. J. Immunol., 160, 5209-5212.
-
(1998)
J. Immunol.
, vol.160
, pp. 5209-5212
-
-
Kraus, E.1
James, W.2
Barclay, A.N.3
-
41
-
-
66249129385
-
Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells
-
Zhou, J. et al. (2009) Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells. Nucleic Acids Res., 37, 3094-3109.
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 3094-3109
-
-
Zhou, J.1
-
42
-
-
21844443592
-
Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1
-
Dey, A.K., Griffiths, C., Lea, S.M., and James, W. (2005) Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1. RNA, 11, 873-884.
-
(2005)
RNA
, vol.11
, pp. 873-884
-
-
Dey, A.K.1
Griffiths, C.2
Lea, S.M.3
James, W.4
-
43
-
-
27144483814
-
An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction
-
Dey, A.K. et al. (2005) An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction. J. Virol., 79, 13806-13810.
-
(2005)
J. Virol.
, vol.79
, pp. 13806-13810
-
-
Dey, A.K.1
-
44
-
-
0035966106
-
Tenascin-C aptamers are generated using tumor cells and purified protein
-
Hicke, B.J. et al. (2001) Tenascin-C aptamers are generated using tumor cells and purified protein. J. Biol. Chem., 276, 48644-48654.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 48644-48654
-
-
Hicke, B.J.1
-
45
-
-
70349898026
-
Reversible cell-specific drug delivery with aptamer-functionalized liposomes
-
Cao, Z. et al. (2009) Reversible cell-specific drug delivery with aptamer-functionalized liposomes. Angew. Chem. Int. Ed., 48, 6494-6498.
-
(2009)
Angew. Chem. Int. Ed.
, vol.48
, pp. 6494-6498
-
-
Cao, Z.1
-
46
-
-
63349112005
-
Phototoxic aptamers selectivelyenter and kill epithelial cancer cells
-
Ferreira, C.S., Cheung, M.C., Missailidis, S., Bisland, S., and Gariepy, J. (2009) Phototoxic aptamers selectivelyenter and kill epithelial cancer cells. Nucleic Acids Res., 37, 866-876.
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 866-876
-
-
Ferreira, C.S.1
Cheung, M.C.2
Missailidis, S.3
Bisland, S.4
Gariepy, J.5
-
47
-
-
56249097260
-
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles
-
Dhar, S., Gu, F.X., Langer, R., Farokhzad, O.C., and Lippard, S.J. (2008) Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc. Natl. Acad. Sci. USA, 105, 17356-17361.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 17356-17361
-
-
Dhar, S.1
Gu, F.X.2
Langer, R.3
Farokhzad, O.C.4
Lippard, S.J.5
-
48
-
-
70249110439
-
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
-
Dassie, J.P. et al. (2009) Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat. Biotechnol., 27, 839-849.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 839-849
-
-
Dassie, J.P.1
-
49
-
-
55449127119
-
Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2
-
Wullner, U. et al. (2008) Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2. Curr. Cancer Drug Targets, 8, 554-565.
-
(2008)
Curr. Cancer Drug Targets
, vol.8
, pp. 554-565
-
-
Wullner, U.1
-
50
-
-
25444482607
-
Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
-
Hu-Lieskovan, S., Heidel, J.D., Bartlett, D.W., Davis, M.E., and Triche, T.J. (2005) Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res., 65, 8984-8992.
-
(2005)
Cancer Res.
, vol.65
, pp. 8984-8992
-
-
Hu-Lieskovan, S.1
Heidel, J.D.2
Bartlett, D.W.3
Davis, M.E.4
Triche, T.J.5
-
51
-
-
48349105059
-
Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy
-
Zhou, J., Li, H., Li, S., Zaia, J., and Rossi, J.J. (2008) Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy. Mol. Ther., 16, 1481-1489.
-
(2008)
Mol. Ther.
, vol.16
, pp. 1481-1489
-
-
Zhou, J.1
Li, H.2
Li, S.3
Zaia, J.4
Rossi, J.J.5
-
52
-
-
65549102827
-
Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells
-
Huang, Y.F. et al. (2009) Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells. ChemBioChem, 10, 862-868.
-
(2009)
ChemBioChem
, vol.10
, pp. 862-868
-
-
Huang, Y.F.1
-
53
-
-
68249159427
-
Viral capsid DNA aptamer conjugates as multivalent cell-targeting vehicles
-
Tong, G.J., Hsiao, S.C., Carrico, Z.M., and Francis, M.B. (2009) Viral capsid DNA aptamer conjugates as multivalent cell-targeting vehicles. J. Am. Chem. Soc., 131, 11174-11178.
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 11174-11178
-
-
Tong, G.J.1
Hsiao, S.C.2
Carrico, Z.M.3
Francis, M.B.4
-
54
-
-
41649102043
-
The cancer biomarker problem
-
Sawyers, C.L. (2008) The cancer biomarker problem. Nature, 452, 548-552.
-
(2008)
Nature
, vol.452
, pp. 548-552
-
-
Sawyers, C.L.1
-
55
-
-
0347364648
-
A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment
-
Daniels, D.A., Chen, H., Hicke, B.J., Swiderek, K.M., and Gold, L. (2003) A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment. Proc. Natl. Acad. Sci. USA, 100, 15416-15421.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 15416-15421
-
-
Daniels, D.A.1
Chen, H.2
Hicke, B.J.3
Swiderek, K.M.4
Gold, L.5
-
56
-
-
43049143065
-
CELL-SELEX: Novel perspectives of aptamer-based therapeutics
-
Guo, K.T., Ziemer, G., Paul, A., and Wendel, H.P. (2008) CELL-SELEX: Novel perspectives of aptamer-based therapeutics. Int. J. Mol. Sci., 9, 668-678.
-
(2008)
Int. J. Mol. Sci.
, vol.9
, pp. 668-678
-
-
Guo, K.T.1
Ziemer, G.2
Paul, A.3
Wendel, H.P.4
-
57
-
-
75449119505
-
Aptamers generated from cell-SELEX for molecular medicine: a chemical biology approach
-
Fang, X. and Tan, W. (2009) Aptamers generated from cell-SELEX for molecular medicine: a chemical biology approach. Acc. Chem. Res., 43, 48-57.
-
(2009)
Acc. Chem. Res.
, vol.43
, pp. 48-57
-
-
Fang, X.1
Tan, W.2
-
58
-
-
34249870129
-
Aptamers evolved from cultured cancer cells reveal molecular differences of cancer cells in patient samples
-
Shangguan, D., Cao, Z.C., Li, Y., and Tan, W. (2007) Aptamers evolved from cultured cancer cells reveal molecular differences of cancer cells in patient samples. Clin. Chem., 53, 1153-1155.
-
(2007)
Clin. Chem.
, vol.53
, pp. 1153-1155
-
-
Shangguan, D.1
Cao, Z.C.2
Li, Y.3
Tan, W.4
-
59
-
-
46049108242
-
Cell-specific internalization study of an aptamer from whole cell selection
-
Xiao, Z., Shangguan, D., Cao, Z., Fang, X., and Tan, W. (2008) Cell-specific internalization study of an aptamer from whole cell selection. Chemistry, 14, 1769-1775.
-
(2008)
Chemistry
, vol.14
, pp. 1769-1775
-
-
Xiao, Z.1
Shangguan, D.2
Cao, Z.3
Fang, X.4
Tan, W.5
-
60
-
-
48149099772
-
Enrichment of cell-targeting and population-specific aptamers by fluorescence-activated cell sorting
-
Raddatz, M.S. et al. (2008) Enrichment of cell-targeting and population-specific aptamers by fluorescence-activated cell sorting. Angew. Chem. Int. Ed. Engl., 47, 5190-5193.
-
(2008)
Angew. Chem. Int. Ed. Engl.
, vol.47
, pp. 5190-5193
-
-
Raddatz, M.S.1
-
61
-
-
38349089990
-
Methods for selection of aptamers to protein targets
-
Kulbachinskiy, A.V. (2007) Methods for selection of aptamers to protein targets. Biochemistry., 72, 1505-1518.
-
(2007)
Biochemistry.
, vol.72
, pp. 1505-1518
-
-
Kulbachinskiy, A.V.1
-
62
-
-
77954362096
-
Aptamer-targeted cell-specific RNA interference
-
Zhou, J. and Rossi, J.J. (2010) Aptamer-targeted cell-specific RNA interference. Silence, 1, 4.
-
(2010)
Silence
, vol.1
, pp. 4
-
-
Zhou, J.1
Rossi, J.J.2
-
63
-
-
34247186502
-
Using aptamers to identify and enter cells
-
Chu, T., Ebright, J., and Ellington, A.D. (2007) Using aptamers to identify and enter cells. Curr. Opin. Mol. Ther., 9, 137-144.
-
(2007)
Curr. Opin. Mol. Ther.
, vol.9
, pp. 137-144
-
-
Chu, T.1
Ebright, J.2
Ellington, A.D.3
-
64
-
-
0019212385
-
Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells
-
Stirpe, F., Olsnes, S., and Pihl, A. (1980) Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A. J. Biol. Chem., 255, 6947-6953.
-
(1980)
Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A. J. Biol. Chem.
, vol.255
, pp. 6947-6953
-
-
Stirpe, F.1
Olsnes, S.2
Pihl, A.3
-
65
-
-
0028228495
-
Gelonin analogs with engineered cysteine residues form antibody immunoconjugates with unique properties
-
Better, M. et al. (1994) Gelonin analogs with engineered cysteine residues form antibody immunoconjugates with unique properties. J. Biol. Chem., 269, 9644-9650.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 9644-9650
-
-
Better, M.1
-
66
-
-
38849194768
-
Cancer cell targeting using multiple aptamers conjugated on nanorods
-
Huang, Y.F., Chang, H.T., and Tan, W. (2008) Cancer cell targeting using multiple aptamers conjugated on nanorods. Anal. Chem., 80, 567-572.
-
(2008)
Anal. Chem.
, vol.80
, pp. 567-572
-
-
Huang, Y.F.1
Chang, H.T.2
Tan, W.3
-
67
-
-
55549144337
-
Selective photothermal therapy for mixed cancer cells using aptamer-conjugated nanorods
-
Huang, Y.F., Sefah, K., Bamrungsap, S., Chang, H.T., and Tan, W. (2008) Selective photothermal therapy for mixed cancer cells using aptamer-conjugated nanorods. Langmuir, 24, 11860-11865.
-
(2008)
Langmuir
, vol.24
, pp. 11860-11865
-
-
Huang, Y.F.1
Sefah, K.2
Bamrungsap, S.3
Chang, H.T.4
Tan, W.5
-
68
-
-
0036308857
-
RNA interference: antiviral defense and genetic tool
-
Cullen, B.R. (2002) RNA interference: antiviral defense and genetic tool. Nat. Immunol., 3, 597-599.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 597-599
-
-
Cullen, B.R.1
-
69
-
-
22844444380
-
On the delivery of small interfering RNAs into mammalian cells
-
Sioud, M. (2005) On the delivery of small interfering RNAs into mammalian cells. Expert Opin. Drug Deliv., 2, 639-651.
-
(2005)
Expert Opin. Drug Deliv.
, vol.2
, pp. 639-651
-
-
Sioud, M.1
-
70
-
-
32444445649
-
Harnessing in vivo siRNA delivery for drug discovery and therapeutic development
-
Xie, F.Y., Woodle, M.C., and Lu, P.Y. (2006) Harnessing in vivo siRNA delivery for drug discovery and therapeutic development. Drug Discov. Today, 11, 67-73.
-
(2006)
Drug Discov. Today
, vol.11
, pp. 67-73
-
-
Xie, F.Y.1
Woodle, M.C.2
Lu, P.Y.3
-
71
-
-
0033621140
-
RNA aptamers as effective protein antagonists in a multicellular organism
-
Shi, H., Hoffman, B.E., and Lis, J.T. (1999) RNA aptamers as effective protein antagonists in a multicellular organism. Proc. Natl. Acad. Sci. USA, 96, 10033-10038.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 10033-10038
-
-
Shi, H.1
Hoffman, B.E.2
Lis, J.T.3
-
72
-
-
0242610799
-
Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity
-
Santulli-Marotto, S., Nair, S.K., Rusconi, C., Sullenger, B., and Gilboa, E. (2003) Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity. Cancer Res., 63, 7483-7489.
-
(2003)
Cancer Res.
, vol.63
, pp. 7483-7489
-
-
Santulli-Marotto, S.1
Nair, S.K.2
Rusconi, C.3
Sullenger, B.4
Gilboa, E.5
-
73
-
-
38149096315
-
Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice
-
McNamara, J.O. et al. (2008) Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. J. Clin. Invest., 118, 376-386.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 376-386
-
-
McNamara, J.O.1
-
74
-
-
46849111987
-
Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer
-
Dollins, C.M. et al. (2008) Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer. Chem. Biol., 15, 675-682.
-
(2008)
Chem. Biol.
, vol.15
, pp. 675-682
-
-
Dollins, C.M.1
-
75
-
-
0027163099
-
In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits
-
Griffin, L.C., Tidmarsh, G.F., Bock, L.C., Toole, J.J., and Leung, L.L. (1993) In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits. Blood, 81, 3271-3276.
-
(1993)
Blood
, vol.81
, pp. 3271-3276
-
-
Griffin, L.C.1
Tidmarsh, G.F.2
Bock, L.C.3
Toole, J.J.4
Leung, L.L.5
-
77
-
-
77952248366
-
Epidemiology and risk factors for kidney cancer
-
Chow, W.H., Dong, L.M., and Devesa, S.S. (2010) Epidemiology and risk factors for kidney cancer. Nat. Rev. Urol., 7, 245-257.
-
(2010)
Nat. Rev. Urol.
, vol.7
, pp. 245-257
-
-
Chow, W.H.1
Dong, L.M.2
Devesa, S.S.3
-
78
-
-
33645095226
-
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
-
Ng, E.W. et al. (2006) Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat. Rev. Drug Discov., 5, 123-132.
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 123-132
-
-
Ng, E.W.1
-
79
-
-
19944428130
-
'-O-methyl aptamer to VEGF
-
'-O-methyl aptamer to VEGF. Chem. Biol., 12, 25-33.
-
(2005)
Chem. Biol.
, vol.12
, pp. 25-33
-
-
Burmeister, P.E.1
-
80
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek, J. et al. (2004) Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature, 432, 173-178.
-
(2004)
Nature
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
-
81
-
-
8344221992
-
Antidote-mediated control of an anticoagulant aptamer in vivo
-
Rusconi, C.P. et al. (2004) Antidote-mediated control of an anticoagulant aptamer in vivo. Nat. Biotechnol., 22, 1423-1428.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1423-1428
-
-
Rusconi, C.P.1
-
82
-
-
0033790673
-
Escort aptamers: a delivery service for diagnosis and therapy
-
Hicke, B.J. and Stephens, A.W. (2000) Escort aptamers: a delivery service for diagnosis and therapy. J. Clin. Invest., 106, 923-928.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 923-928
-
-
Hicke, B.J.1
Stephens, A.W.2
-
83
-
-
0029824564
-
Small peptides radiolabeled with 99mTc
-
Lister-James, J., Moyer, B.R., and Dean, T. (1996) Small peptides radiolabeled with 99mTc. Q. J. Nucl. Med., 40, 221-233.
-
(1996)
Q. J. Nucl. Med.
, vol.40
, pp. 221-233
-
-
Lister-James, J.1
Moyer, B.R.2
Dean, T.3
-
84
-
-
33745108827
-
Tumor targeting by an aptamer
-
Hicke, B.J. et al. (2006) Tumor targeting by an aptamer. J. Nucl. Med., 47, 668-678.
-
(2006)
J. Nucl. Med.
, vol.47
, pp. 668-678
-
-
Hicke, B.J.1
-
85
-
-
7444267493
-
Toxicology of antisense therapeutics
-
Jason, T.L., Koropatnick, J., and Berg, R.W. (2004) Toxicology of antisense therapeutics. Toxicol. Appl. Pharmacol., 201, 66-83.
-
(2004)
Toxicol. Appl. Pharmacol.
, vol.201
, pp. 66-83
-
-
Jason, T.L.1
Koropatnick, J.2
Berg, R.W.3
-
86
-
-
0032697942
-
A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides
-
Levin, A.A. (1999) A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochim. Biophys. Acta, 1489, 69-84.
-
(1999)
Biochim. Biophys. Acta
, vol.1489
, pp. 69-84
-
-
Levin, A.A.1
-
87
-
-
0036844423
-
Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide
-
Henry, S.P. et al. (2002) Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide. Int. Immunopharmacol., 2, 1657-1666.
-
(2002)
Int. Immunopharmacol.
, vol.2
, pp. 1657-1666
-
-
Henry, S.P.1
-
88
-
-
77953532645
-
Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9
-
Lenert, P.S. (2010) Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9. Mediators Inflamm., 2010, 986596.
-
(2010)
Mediators Inflamm.
, vol.2010
, pp. 986596
-
-
Lenert, P.S.1
-
89
-
-
69049101144
-
Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9
-
Yu, D. et al. (2009) Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9. J. Med. Chem., 52, 5108-5114.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 5108-5114
-
-
Yu, D.1
-
90
-
-
45949092349
-
Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers
-
Cooper, C.L. et al. (2008) Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers. J. Immune Based Ther. Vaccines, 6, 3.
-
(2008)
J. Immune Based Ther. Vaccines
, vol.6
, pp. 3
-
-
Cooper, C.L.1
-
91
-
-
37849002321
-
Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
-
Krieg, A.M. (2008) Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene, 27, 161-167.
-
(2008)
Oncogene
, vol.27
, pp. 161-167
-
-
Krieg, A.M.1
|