Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 33, Issue 2, 2009, Pages 308-311

  Monji, Akira ^a   Takita, Masashi ^b   Samejima, Takaaki ^c   Takaishi, Toshihiro ^c   Hashimoto, Kazuhito ^d   Matsunaga, Hiroyuki ^e   Oda, Mariko ^f   Sumida, Yasuhisa ^g   Mizoguchi, Yoshito ^a   Kato, Takahiro ^a   Horikawa, Hideki ^a   Kanba, Shigenobu ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Imazu Sekijuji Hospital   (Japan)

^c Sameshima Hospital   (Japan)

^d Seiyu Hospital   (Japan)

^e Hayatsue Hospital   (Japan)

^f Nakataku Hospital   (Japan)

^g Sumida Hospital   (Japan)

Author keywords

Alzheimer's disease (AD); Behavioral and psychological symptoms of dementia (BPSD); Herbal medicine; Sulpiride; Yokukansan

Indexed keywords

NOOTROPIC AGENT; POTASSIUM; SULPIRIDE; UNCLASSIFIED DRUG; YOKUKANSAN;

AGED; ALZHEIMER DISEASE; ARTICLE; BARTHEL INDEX; BEHAVIOR DISORDER; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DRUG DOSE REDUCTION; EXTRAPYRAMIDAL SYMPTOM; FEMALE; HUMAN; HYPOKALEMIA; MALE; MENTAL DISEASE; MINI MENTAL STATE EXAMINATION; NEUROPSYCHIATRIC INVENTORY; PSYCHOLOGICAL RATING SCALE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIPSYCHOTIC AGENTS; BEHAVIOR; DRUG THERAPY, COMBINATION; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; SULPIRIDE;

EID: 60049099127     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.12.008     Document Type: Article

References (25)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Association, Washington, DC
2. Assal F., Alarcon M., Solomon E.C., Masterman D., Geschwind D.H., and Cummings J.L. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. Arch Neurol 61 8 (2004) 1249-1253
3. Cummings J.L., Mega M., Gray K., Rosenberg-Thompson S., Carusi D.A., and Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 44 12 (1994) 2308-2314
4. Dos Santos-Neto L.L., de Vilhena Toledo M.A., Medeiros-Souza P., and de Souza G.A. The use of herbal medicine in Alzheimer's disease-a systematic review. Evid Based Complement Alternat Med 3 4 (2006) 441-445
5. 2A receptors in the prefrontal cortex. Prog Neuro-Psychopharmacol Biol Psychiatr 32 6 (2008) 1516-1520
6. Iwasaki K., Satoh-Nakagawa T., Maruyama M., Monma Y., Nemoto M., Tomita N., et al. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatr 66 2 (2005) 248-252
7. Iwasaki K., Maruyama M., Tomita N., Furukawa K., Nemoto M., Fujiwara H., et al. Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies. J Clin Psychiatr 66 12 (2005) 1612-1613
8. Jeste D.V., Blazer D., Casey D., Meeks T., Salzman C., Schneider L., et al. ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology 33 5 (2008) 957-970
9. Kuehn B.M. FDA: Antipsychotics Risky for Elderly 300 (4) (2008), JAMA 379-380
10. 2AT102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease. Int J Geriat Psychiatr 19 6 (2004) 523-536
11. Lanari A., Amenta F., Silvestrelli G., Tomassoni D., and Parnetti L. Neurotransmitter deficits in behavioral and psychological symptoms of Alzheimer's disease. Mech Age Develop 127 2 (2006) 158-165
12. Lawlor B. Managing behavioural and psychological symptoms in dementia. Br J Psychiatr 181 (2002) 463-465
13. Liao J.F., Jan Y.M., Huang S.Y., Wang H.H., Yu L.L., and Chen C.F. Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs. Proc Natl Sci Counc Repub China, B 19 13 (1995) 151-158
14. Mahoney F.I., and Barthel D.W. Functional evaluation:The Barthel Index. Md State Med J 14 (1965) 61-65
15. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Standlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 7 (1984) 939-944
16. Mckeith I., and Cummings J. Behavioural changes and psychological symptoms in dementia disorders. Lancet Neurol 4 11 (2005) 735-742
17. Pritchard A.L., Pritchard C.W., Bentham P., and Lendon C.L. Role of serotonin transporter polymorphisms in the behavioural and psychological symptoms in probable Alzheimer disease patients. Dement Geriatr Cogn Disord 24 3 (2007) 201-206
18. Pritchard A.L., Harris J., Prichard C.W., Coates J., Haque S., Holder R., et al. Role of 5HT2A and 5HT2C polymorphisms in behavioural and psychological symptoms of Alzheimer's disease. Neurobiol Aging 29 3 (2008) 341-347
19. Rainer M., Haushofer M., Pfolz H., Struhal C., and Wick W. Quetiapine versus risperidone in elderly patients with behavioural and psychological symptoms of dementia: Efficacy, safety and cognitive function. Eur Psychiatr 22 6 (2007) 395-403
20. Shinno H., Utani E., Okazaki S., Kawamukai T., Yasuda H., Inagaki T., et al. Successful treatment with Yi-Gan San for psychosis and sleep disturbance in a patient with dementia with Lewy bodies. Prog Neuro-Psychopharmacol Biol Psychiatr 31 7 (2007) 1543-1545
21. Shinno H., Inami Y., Inagaki T., Nakamura Y., and Horiguchi J. Effect of Yi-Gan-San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia. Prog Neuro-Psychopharmacol Biol Psychiatr 32 3 (2008) 881-885
22. Schneider L.S., Tariot P.N., Dagerman K.S., Davis S.M., Hsiao J.K., Ismail M.S., et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. N Engl J Med 355 15 (2006) 1525-1538
23. Sultzer D.L., Davis S.M., Tariot P.N., Dagerman K.S., Lebowitz B.D., Lyketsos C.G., Rosenheck R.A., et al. Clinical symptom responses to atypical antipsychotic medications in Alzheimer's disease: Phase 1 outcomes from CATIE-AD effectiveness trial. Am J Psychiatr 165 7 (2008) 844-854
24. Tateno M., Ukai W., Ono T., Saito S., Hashimoto E., and Saito T. Neuroprotective effects of Yi-Gan San against beta amyloid-induced cytotoxicity on rat cortical neurons. Prog Neuro-Psychopharmacol Biol Psychiatr 32 (2008) 1704-1707
25. Zubenko G.S., Moosy J., Martinez A.J., Rao G., Claassen D., Rosen J., et al. Neuropathologic and neurochemical correlates of psychosis in primary dementia. Arch Neurol 48 6 (1991) 619-624