Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 9, 2009, Pages 1249-1256

  Kanno, Hitomi ^a   Sekiguchi, Kyoji ^a   Yamaguchi, Takuji ^a   Terawaki, Kiyoshi ^a   Yuzurihara, Mitsutoshi ^a   Kase, Yoshio ^a   Ikarashi, Yasushi ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

Aggressive behaviour; p chloroamphetamine; Social behaviour; Yokukansan

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; BUSPIRONE; CHLORAMPHETAMINE; KAMPO; KETANSERIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; POTASSIUM ION; SEROTONIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG; YOKUKANSAN; HERBACEOUS AGENT; POTASSIUM; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; YI GAN SAN; YI-GAN SAN;

AGGRESSION; ANIMAL EXPERIMENT; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG EFFECT; HYPOTHALAMUS; INJECTION; JAPANESE; MALE; NONHUMAN; RAT; SEROTONIN BLOOD LEVEL; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; SOCIAL BEHAVIOR; SOCIAL INTERACTION; TRADITIONAL MEDICINE; ANIMAL; ANIMAL BEHAVIOR; DRUG INTERACTION; JAPAN; METABOLISM; ORIENTAL MEDICINE; TIME; WISTAR RAT;

AGGRESSION; ANIMALS; BEHAVIOR, ANIMAL; DRUG INTERACTIONS; DRUGS, CHINESE HERBAL; HYPOTHALAMUS; JAPAN; MALE; MEDICINE, EAST ASIAN TRADITIONAL; P-CHLOROAMPHETAMINE; POTASSIUM; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SOCIAL BEHAVIOR; TIME FACTORS;

EID: 70350517597     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp/61.09.0016     Document Type: Article

References (42)

1. Nagaratnam N et al. Behavioral and psychiatric manifestations in dementia patients in a community: caregiver burden and outcome. Alzheimer Dis Assoc Disord 1998; 12: 330-334.
2. Tanji H et al. Dementia caregivers' burdens and use of public services. Geriatr Gerontol Int 2005; 5: 94-98.
3. Steele C et al. Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease. Am J Psychiatry 1990; 147: 1049-1051.
4. Food and Drug Administration. FDA public health advisory: deaths with antipsychotics in elderly patients with behavioral disturbances. http://www.fda.gov/cder/drug/advisory/antipsych otics.htm (accessed 11 April 2005).
5. Iwasaki K et al. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatry 2005; 66: 248-252.
6. Iwasaki K et al. Effect of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies. J Clin Psychiatry 2005; 66: 1612-1613.
7. Mizukami K et al. A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia. Int J Neuropsychopharmacol 2009; 12: 191-199.
8. Shinno H et al. Successful treatment with Yi-Gan San for psychosis and sleep disturbance in a patient with dementia with Lewy bodies. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 1543-1545.
9. Aletrino MA et al. Cell loss in the nucleus raphes dorsalis in Alzheimer's disease. Neurobiol Aging 1992; 13: 461-468.
10. Halliday GM et al. Brain stem serotonin-synthesizing neurons in Alzheimer's disease: a clinicopathological correlation. Acta Neuropathol 1992; 84: 638-650.
11. Yamamoto T, Hirano A. Nucleus raphe dorsalis in Alzheimer's disease: neurofibrillary tangles and loss of large neurons. Ann Neurol 1985; 17: 573-577.
12. Lai MK et al. Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease. Brain Res 2003; 974: 82-87.
13. Nichols DE. Hallucinogens. Pharmacol Ther 2004; 101: 131-181.
14. Ando RD et al. Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test. Neuropharmacology 2006; 50: 884-896.
15. Bjork JM et al. The effects of tryptophan depletion and loading on laboratory aggression in men: time course and a foodrestricted control. Psychopharmacology (Berl) 1999; 142: 24-30.
16. Keele NB. Phenytoin inhibits isolation-induced aggression specifically in rats with low serotonin. Neuroreport 2001; 12: 1107-1112.
17. Vergnes M et al. Selective increase of offensive behavior in the rat following intrahypothalamic 5,7-DHT-induced serotonin depletion. Behav Brain Res 1988; 29: 85-91.
18. Sheard MH, Davis M. p-Chloroamphetamine: short and long term effects upon shock-elicited aggression. Eur J Pharmacol 1976; 40: 295-302.
19. Winslow JT, Miczek KA. Habituation of aggression in mice: pharmacological evidence of catecholaminergic and serotonergic mediation. Psychopharmacology (Berl) 1983; 81: 286-291.
20. Terawaki K et al. Partial agonistic effects for serotonin 1A receptors of yokukansan, a traditional Japanese medicine. Bull Jpn Soc Neurochem 2008; 47 (Suppl.): 257.
21. Fuller RW. Effects of p-chloroamphetamine on brain serotonin neurons. Neurochem Res 1992; 17: 449-456.
22. Sekiguchi K et al. Effects of yokukansan, a traditional Japanese medicine, on aggressiveness induced by intracerebroventricular injection of amyloid b protein into mice. Phytother Res 2009 (in press).
23. Ikarashi Y et al. Binding characteristics of various neurochemicals to glassy carbon. J Chromatogr 1993; 645: 219-231.
24. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 2nd edn. Australia, Sydney: Academic Press, 1986.
25. Shioda K et al. Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. Neurotoxicology 2008; 29: 1030-1036.
26. Gibb JW et al. The effects of amphetamine-like designer drugs on monoaminergic systems in rat brain. NIDA Res Monogr 1987; 76: 316-321.
27. Peat MA et al. The acute effects of methamphetamine, amphetamine and p-chloroamphetamine on the cortical serotonergic system of the rat brain: evidence for differences in the effects of methamphetamine and amphetamine. Eur J Pharmacol 1985; 116: 11-16.
28. Wasman M, Flynn JR. Directed attack elicited from hypothalamus. Arch Neurol 1962; 6: 220-227.
29. Carrasco GA et al. Single exposure to a serotonin 1A receptor agonist, (+)8-hydroxy-2-(di-n-propylamino)-tetralin, produces a prolonged heterologous desensitization of serotonin 2A receptors in neuroendocrine neurons in vivo. J Pharmacol Exp Ther 2007; 320: 1078-1086.
30. Ikarashi Y et al. Postmortem changes in catecholamines, indoleamines, and their metabolites in rat brain regions: prevention with 10-kW microwave irradiation. J Neurochem 1985; 45: 935-939.
31. Amargos-Bosch M et al. Co-expression and in vivo interaction of serotonin 1A and serotonin 2A receptors in pyramidal neurons of prefrontal cortex. Cereb Cortex 2004; 14: 281-299.
32. Darmani NA et al. Do functional relationships exist between 5-HT1A and 5-HT2 receptors? Pharmacol Biochem Behav 1990; 36: 901-906.
33. Kitamura Y et al. The 5-HT1A receptor full agonist 8-OHDPAT inhibits ACTH-induced 5-HT2A receptor hyperfunction in rats: involvement of 5-HT1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats. Biol Pharm Bull 2007; 30: 117-120.
34. Sakaue M et al. Modulation by 5-HT2A receptors of aggressive behavior in isolated mice. Jpn J Pharmacol 2002; 89: 89-92.
35. Wieland S et al. Effect of chronic treatments with tandospirone and imipramine on serotonin-mediated behavioral responses and monoamine receptors. Neuropharmacology 1993; 32: 561-573.
36. File SE, Seth P. A review of 25 years of the social interaction test. Eur J Pharmacol 2003; 463: 35-53.
37. Kuribara H, Maruyama Y. The anxiolytic effect of oriental herbal medicines by an improved plus-maze test in mice. Jpn J Neuropsychopharmacol 1996; 18: 179-190.
38. Egashira N et al. Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT) 2A receptors in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 1516-1520.
39. Zhu M et al. Application of radioligand receptor binding assays in the search for CNS active principles from Chinese medicinal plants. J Ethnopharmacol 1996; 54: 153-164.
40. Jung JW et al. Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla. J Ethonopharmacol 2006; 108: 193-197.
41. Kanatani H et al. The active principles of the branchlet and hook of Uncaria sinensis Oliv. examined with a 5-hydroxytryptamine receptor binding assay. J Pharm Pharmacol 1985; 37: 401-404.
42. Pengsuparp T et al. Pharmacological studies of geissoschizine methyl ether, isolated from Uncaria sinensis Oliv., in the central nervous system. Eur J Pharmacol 2001; 425: 211-218.