Geissoschizine methyl ether, an indole alkaloid extracted from Uncariae Ramulus et Uncus, is a potent vasorelaxant of isolated rat aorta

European Journal of Pharmacology

Volumn 444, Issue 3, 2002, Pages 183-189

  Yuzurihara, Mitsutoshi ^a   Ikarashi, Yasushi ^a   Goto, Kazuhiro ^a   Sakakibara, Iwao ^a   Hayakawa, Terumasa ^a   Sasaki, Hiroshi ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

Aorta, rat; Ca2+ channel; Endothelium; Geissoschizine methyl ether; Nitric oxide (NO); Vasorelaxation

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; GEISSOSCHIZINE METHYL ETHER; HIRSUTINE; INDOLE ALKALOID; N(G) NITROARGININE; NITRIC OXIDE; NORADRENALIN; PLANT EXTRACT; POTASSIUM ION; UNCARIAE RAMULUS EXTRACT; UNCLASSIFIED DRUG; GEISSOSCHIZINE METHYLETHER; INDOLE DERIVATIVE;

ANIMAL TISSUE; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ISOLATED ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; AORTA; CHEMISTRY; DOSE RESPONSE; IN VITRO STUDY; ISOLATION AND PURIFICATION; PHYSIOLOGY; UNCARIA; VASCULAR ENDOTHELIUM; VASODILATATION; WISTAR RAT;

ANIMAL; AORTA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; IN VITRO; INDOLE ALKALOIDS; INDOLES; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; UNCARIA; VASODILATION; ANIMALS;

EID: 0037204739     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01623-0     Document Type: Article

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