Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid β proteins in amyloid precursor protein transgenic mice

Neuroscience

Volumn 180, Issue , 2011, Pages 305-313

  Fujiwara, H ^a   Takayama, S ^a   Iwasaki, K ^a,b   Tabuchi, M ^c   Yamaguchi, T ^c   Sekiguchi, K ^c   Ikarashi, Y ^c   Kudo, Y ^d   Kase, Y ^c   Arai, H ^d   Yaegashi, N ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b National Hospital Organization Sendai Nishitaga Hospital   (Japan)

^c TSUMURA AND CO   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

Aggression; Alzheimer's disease; Amyloid proteins; Traditional medicine; Uncaria hook; Yokukansan

Indexed keywords

AMYLOID PRECURSOR PROTEIN; HERBACEOUS AGENT; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; YOKUKANSAN;

AGGRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMORY DISORDER; MOUSE; NONHUMAN; PLANT HOOK; PLANT MORPHOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; SOCIAL INTERACTION; SOCIOPATHY; TRADITIONAL MEDICINE; TRANSGENIC MOUSE; UNCARIA; UNCARIA RHYNCHOPHYLLA;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; INTERPERSONAL RELATIONS; JAPAN; MALE; MEDICINE, EAST ASIAN TRADITIONAL; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; NEUROPROTECTIVE AGENTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 79953218001     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.01.064     Document Type: Article

References (47)

1. Adriani W., Ognibene E., Heuland E., Ghirardi O., Caprioli A., Laviola G. Motor impulsivity in APP-SWE mice: a model of Alzheimer's disease. Behav Pharmacol 2006, 17:525-533.
2. Barghorn S., Nimmrich V., Striebinger A., Krantz C., Keller P., Janson B., Bahr M., Schmidt M., Bitner R.S., Harlan J., Barlow E., Ebert U., Hillen H. Globular amyloid β-peptide1-42 oligomer-a homogenous and stable neuropathological protein in Alzheimer's disease. J Neurochem 2005, 95:834-847.
3. Barnes P., Hale G., Good M. Intramaze and extramaze cue processing in adult APPSWE Tg2576 transgenic mice. Behav Neurosci 2004, 118:1184-1195.
4. Barrow C.J., Zagorski M.G. Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition. Science 1991, 253:179-182.
5. Calon F., Lim G.P., Yang F., Morihara T., Teter B., Ubeda O., Rostaing P., Triller A., Salem N., Ashe K.H., Frautschy S.A., Cole G.M. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 2004, 43:633-645.
6. Darreh-Shori T., Hellström-Lindahl E., Flores-Flores C., Guan Z.Z., Soreq H., Nordberg A. Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients. J Neurochem 2004, 88:1102-1113.
7. Dong H., Csernansky C.A., Martin M.V., Bertchume A., Vallera D., Csernansky J.G. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology 2005, 181:145-152.
8. Egashira N., Iwasaki K., Ishibashi A., Hayakawa K., Okuno R., Abe M., Uchida N., Mishima K., Takasaki K., Nishimura R., Oishi R., Fujiwara M. Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:1516-1520.
9. File S.E. The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs. J Neurosci Methods 1980, 2:219-238.
10. Fujiwara H., Iwasaki K., Furukawa K., Seki T., He M., Maruyama M., Tomita N., Kudo Y., Higuchi M., Saido T.C., Maeda S., Takashima A., Hara M., Ohizumi Y., Arai H. Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's β-amyloid proteins. J Neurosci Res 2006, 84:427-433.
11. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 1996, 274:99-102.
12. Ikarashi Y., Harigaya Y., Tomidokoro Y., Kanai M., Ikeda M., Matsubara E., Kawarabayashi T., Kuribara H., Younkin S.G., Maruyama Y., Shoji M. Decreased level of brain acetylcholine and memory disturbance in APPSW mice. Neurobiol Aging 2004, 25:483-490.
13. Ikarashi Y., Iizuka S., Imamura S., Yamaguchi T., Sekiguchi K., Kanno H., Kawakami Z., Yuzurihara M., Kase Y., Takeda S. Effects of Yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. Biol Pharm Bull 2009, 32:1701-1709.
14. Iwasaki K., Kobayashi S., Chimura Y., Taguchi M., Inoue K., Cho S., Akiba T., Arai H., Cyong J.C., Sasaki H. A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine "ba wei di huang wan" in the treatment of dementia. J Am Geriatr Soc 2004, 52:1518-1521.
15. Iwasaki K., Satoh-Nakagawa T., Maruyama M., Monma Y., Nemoto M., Tomita N., Tanji H., Fujiwara H., Seki T., Fujii M., Arai H., Sasaki H. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatry 2005, 66:248-252.
16. Iwasaki K., Maruyama M., Tomita N., Furukawa K., Nemoto M., Fujiwara H., Seki T., Fujii M., Kodama M., Arai H. Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies. J Clin Psychiatry 2005, 66:1612-1613.
17. Kanno H., Sekiguchi K., Yamaguchi T., Terawaki K., Yuzurihara M., Kase Y., Ikarashi Y. Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats. J Pharm Pharmacol 2009, 61:1249-1256.
18. Kawakami Z., Kanno H., Ueki T., Terawaki K., Tabuchi M., Ikarashi Y., Kase Y. Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells. Neuroscience 2009, 159:1397-1407.
19. Kawakami Z., Ikarashi Y., Kase Y. Glycyrrhizin and its metabolite 18β-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes. Eur J Pharmacol 2010, 626:154-158.
20. Kawarabayashi T., Younkin L.H., Saido T.C., Shoji M., Ashe K.H., Younkin S.G. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 2001, 21(2):372-381.
21. Lalonde R., Lewis T.L., Strazielle C., Kim H., Fukuchi K. Transgenic mice expressing the βAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination. Brain Res 2003, 977:38-45.
22. Makino T., Ohtake N., Watanabe A., Tsuchiya N., Imamura S., Iizuka S., Inoue M., Mizukami H. Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of Glycyrrhizin and its metabolites in a rat model of chronic liver injury. Drug Metab Dispos 2008, 36:1438-1443.
23. Maruyama M., Tomita N., Iwasaki K., Ootsuki M., Matsui O., Nemoto M., Okamura N., Higuchi M., Tsutsui M., Suzuki T., Seki T., Kaneta T., Furukawa K., Arai H. Benefits of combining donepezil plus traditional Japanese herbal medicine on cognition and brain perfusion in Alzheimer's disease: a 12-week observer-blind, donepezil monotherapy controlled trial. J Am Geriatr Soc 2006, 54:869-871.
24. Millard C.B., Broomfield C.A. Anticholinesterases: medical applications of neurochemical principles. J Neurochem 1995, 64:1909-1918.
25. Mizukami K., Asada T., Kinoshita T., Tanaka K., Sonohara K., Nakai R., Yamaguchi K., Hanyu H., Kanaya K., Takao T., Okada M., Kudo S., Kotoku H., Iwakiri M., Kurita H., Miyamura T., Kawasaki Y., Omori K., Shiozaki K., Odawara T., Suzuki T., Yamada S., Nakamura Y., Toba K. A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia. Int J Neuropsychopharmacol 2009, 12:191-199.
26. Nagaratnam N., Lewis-Jones M., Scott D., Palazzi L. Behavioral and psychiatric manifestations in dementia patients in a community: caregiver burden and outcome. Alzheimer Dis Assoc Disord 1998, 12:330-334.
27. Nakagawasai O., Yamadera F., Iwasaki K., Arai H., Taniguchi R., Tan-no K., Sasaki H., Tadano T. Effect of kami-untan-to on the impairment of learning and memory induced by thiamine-deficient feeding in mice. Neuroscience 2004, 125:233-241.
28. Ognibene E., Middei S., Daniele S., Adriani W., Ghirardi O., Caprioli A., Laviola G. Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease. Behav Brain Res 2005, 156:225-232.
29. Ohtake N., Kido A., Kubota K., Tsuchiya N., Morita T., Kase Y., Takeda S. A possible involvement of 3-monoglucuronyl-glycyrrhetinic acid, a metabolite of glycyrrhizin (GL), in GL-induced pseudoaldosteronism. Life Sci 2007, 80:1545-1552.
30. Park C.H., Lee Y.J., Lee S.H., Choi S.H., Kim H.S., Jeong S.J., Kim S.S., Suh Y.H. Dehydroevodiamine. HCl prevents impairment of learning and memory and neuronal loss in rat models of cognitive disturbance. J Neurochem 2000, 74:244-253.
31. Quinn J.F., Bussiere J.R., Hammond R.S., Montine T.J., Henson E., Jones R.E., Stackman R.W. Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. Neurobiol Aging 2007, 28:213-225.
32. Sekiguchi K., Yamaguchi T., Tabuchi M., Ikarashi Y., Kase Y. Effect of yokukansan, a traditional Japanese medicine, on aggressiveness induced by intracerebroventicular injection of amyloid β protein into mice. Phytother Res 2009, 23:1175-1181.
33. Sekiguchi K, Imamura S, Yamaguchi T, Tabuchi M, Kanno H, Terawaki K, Kase Y, Ikarashi Y (in press) Effect of yokukansan and donepezil on learning disturbance and aggressiveness induced by intracerebroventicular injection of amyloid β protein in mice. Phytother Res. Published online in Wiley Online Library () DOI: doi:10.1002/ptr.3287.
34. Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 2002, 298:789-791.
35. Shinno H., Utani E., Okazaki S., Kawamukai T., Yasuda H., Inagaki T., Horiguchi J. Successful treatment with Yi-Gan San for psychosis and sleep disturbance in a patient with dementia with Lewy bodies. Prog Neuro-Psychopharmacol Biol Psychiatry 2007, 31:1543-1545.
36. Shinno H., Inami Y., Inagaki T., Nakamura Y., Horiguchi J. Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:881-885.
37. Stackman R.W., Eckenstein F., Frei B., Kulhanek D., Nowlin J., Quinn J.F. Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment. Exp Neurol 2003, 184:510-520.
38. Suemoto T.A., Okamura N., Shiomitsu T., Suzuki M., Shimadzu H., Akatsu H., Yamamoto T., Kudo Y., Sawada T. In vivo labeling of amyloid with BF-108. Neurosci Res 2004, 48:65-74.
39. Takeda A., Itoh H., Tamano H., Yuzurihara M., Oku N. Suppressive effect of yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats. Nutr Neurosci 2008, 11:41-46.
40. Takeda A., Tamano H., Itoh H., Oku N. Attenuation of abnormal glutamate release in zinc deficiency by zinc and yokukansan. Neurochem Int 2008, 53:230-235.
41. Tanji H., Ootsuka M., Matsui T., Maruyama M., Nemoto M., Tomita N., Seki T., Iwasaki K., Arai H., Sasaki H. Dementia caregivers' burdens and use of public services. Geriatr Gerontol Int 2005, 5:94-98.
42. Tateno M., Ukai W., Ono T., Saito S., Hashimoto E., Saito T. Neuroprotective effects of Yi-Gan San against beta amyloid-induced cytotoxicity on rat cortical neurons. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:1704-1707.
43. Terawaki K., Ikarashi Y., Sekiguchi K., Nakai Y., Kase Y. Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells. J Ethnopharmacol 2010, 127:306-312.
44. Tierney M.C., Fisher R.H., Lewis A.J., Zorzitto M.L., Snow W.G., Reid D.W., Nieuwstraten P. The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 cases. Neurology 1988, 38:359-364.
45. Wang Q., Iwasaki K., Suzuki T., Arai H., Ikarashi Y., Yabe T., Toriizuka K., Hanawa T., Yamada H., Sasaki H. Potentiation of brain acetylcholine neurons by Kami-Untan-To (KUT) in aged mice: implications for a possible antidementia drug. Phytomedicine 2000, 7:253-258.
46. Wegiel J., Wang K.C., Imaki H., Imaki H., Rubenstein R., Wronska A., Osuchowski M., Lipinski W.J., Walker L.C., LeVine H. The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APPSW mice. Neurobiol Aging 2001, 22:49-61.
47. Wirths O., Multhaup G., Bayer T.A. A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade. J Neurochem 2004, 91:513-520.