Metabolism and pharmacokinetics of rhynchophylline in rats

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 4, 2010, Pages 669-676

  Wang, Wei ^a   Ma, Chao Mei ^a   Hattori, Masao ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

10 hydroxyrhynchophylline; 11 hydroxyrhynchophylline; Alkaloid metabolism; Cytochrome p450; Pharmacokinetics; Rhynchophylline

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 3A; DRUG METABOLITE; RHYNCHOPHYLLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BILE LEVEL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME INHIBITION; IN VIVO STUDY; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; FECES; HYDROXYLATION; INDOLE ALKALOIDS; ISOENZYMES; MALE; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; PLANT EXTRACTS; PLANT STEMS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION; UNCARIA;

EID: 77950896211     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.669     Document Type: Article

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