Investigating siRNA delivery to chronic myeloid leukemia K562 cells with lipophilic polymers for therapeutic BCR-ABL down-regulation

Journal of Controlled Release

Volumn 172, Issue 2, 2013, Pages 495-503

  Valencia Serna, Juliana ^a   Gul Uludaǧ, Hilal ^a   Mahdipoor, Parvin ^a   Jiang, Xiaoyan ^b,c   Uludaǧ, Hasan ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cationic polymer; Chronic myeloid leukemia; Hydrophobic modification; Polyethylenimine; siRNA delivery; Transfection

Indexed keywords

CATIONIC POLYMERS; CHRONIC MYELOID LEUKEMIAS; HYDROPHOBIC MODIFICATION; POLYETHYLENIMINES; SIRNA DELIVERY; TRANSFECTION;

CELL DEATH; DISEASES; LIPOSOMES; MOLECULAR WEIGHT; RNA;

FUNCTIONAL POLYMERS;

BCR ABL PROTEIN; GREEN FLUORESCENT PROTEIN; LINOLEIC ACID; LIPOFECTAMINE; MYRISTIC ACID; OCTANOIC ACID; OLEIC ACID; PALMITIC ACID; POLYETHYLENEIMINE; SMALL INTERFERING RNA; STEARIC ACID;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LIPOPHILICITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN TARGETING; REPORTER GENE; RNA INTERFERENCE;

CATIONIC POLYMER; CHRONIC MYELOID LEUKEMIA; CML; GFP; GREEN FLUORESCENT PROTEIN; HYDROPHOBIC MODIFICATION; LA; LINOLEIC ACID; MEAN FLUORESCENCE INTENSITY; MFI; MOLECULAR WEIGHT; MW; PA; PALMITIC ACID; PEI; POLYETHYLENIMINE; RNA INTERFERENCE; RNAI; SHORT INTERFERING RNA; SIRNA; SIRNA DELIVERY; TRANSFECTION;

DOWN-REGULATION; FUSION PROTEINS, BCR-ABL; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; POLYETHYLENEIMINE; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84887114680     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.05.014     Document Type: Article

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