Novel non-viral method for transfection of primary leukemia cells and cell lines

Genetic Vaccines and Therapy

Volumn 2, Issue , 2004, Pages

  Schakowski, Frank ^a   Buttgereit, Peter ^a   Mazur, Martin ^a   Märten, Angela ^b   Schöttker, Björn ^c   Gorschlüter, Marcus ^a   Schmidt Wolf, Inigo G H ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Gene gun; Gene transfer; Green fluorescent protein; Leukemia; Nucleofection

Indexed keywords

DNA; GREEN FLUORESCENT PROTEIN; NAKED DNA;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER THERAPY; CASE REPORT; CELL NUCLEUS; CELL STRAIN HL 60; CELL STRAIN K 562; CONTROLLED STUDY; CYTOTOXICITY; ELECTROPORATION; FEMALE; GENE TARGETING; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMIA CELL LINE; MALE; NONVIRAL GENE THERAPY; PROTEIN EXPRESSION; REPORTER GENE;

EID: 4243076369     PISSN: 14790556     EISSN: None     Source Type: Journal    
DOI: 10.1186/1479-0556-2-1     Document Type: Article

References (45)

1. Adams SW, Emerson SG: Gene therapy for leukemia and lymphoma. Hematol Oncol Clin North Am 1998, 12:631-648.
2. Einhorn S, Strander H: Interferon treatment of human malignancies - a short review. Med Oncol Tumor Pharmacother 1993, 10:25-29.
3. Schmidt-Wolf GD, Schmidt-Wolf IGH: Cytokines and gene therapy. Immunol Today 1995, 16:173-175.
4. Finke S, Trojaneck B, Lefterova P, Csipai M, Wagner E, Neubauer A, Huhn D, Wittig B, Schmidt-Wolf IGH: Increase of proliferation rate and enhancement of antitumor cytotoxicity of human CD3+CD56+ immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene. Gene Therapy 1998, 5:31-39.
5. Zheng Z, Takahashi M, Aoki S, Toba K, Liu A, Osman Y, Takahashi H, Tsukada N, Suzuki N, Nikkuni K, Furukawa T, Koike T, Aizawa Y: Expression patterns of costimulatory molecules on cells derived from human hematological malignancies. J Exp Clin Cancer Res 1998, 17:251-258.
6. Stripecke R, Cardoso AA, Pepper KA, Skelton DC, Yu XJ, Mascarenhas L, Weinberg KI, Nadler LM, Kohn DB: Lentiviral vectors for efficient delivery of CD80 and granulocyte-macrophage-colony-stimulating factor in human acute lymphoblastic leukemia and acute myeloid leukemia cells to induce antileukemic immune responses. Blood 2000, 96:1317-1326.
7. Notter M, Willinger T, Erben U, Thiel E: Targeting of a B7-1 (CD80) immunoglobulin G fusion protein to acute myeloid leukemia blasts increases their costimulatory activity for autologous remission T cells. Blood 2001, 97:3138-3145.
8. Kato K, Cantwell MJ, Sharma S, Kipps TJ: Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells. J Clin Invest 1998, 101:1133-1141.
9. Wierda WG, Kipps TJ: Gene therapy of hematologic malignancies. Semin Oncol 2000, 27:502-511.
10. Prince HM, Dessureault S, Gallinger S, Krajden M, Sutherland DR, Addison C, Zhang Y, Graham FL, Stewart AK: Efficient adenovirus-mediated gene expression in malignant human plasma cells: relative lymphoid cell resistance. Exp Hematol 1998, 26:27-36.
11. Buttgereit P, Weineck S, Ropke G, Marten A, Brand K, Heinicke T, Caselmann WH, Huhn D, Schmidt-Wolf IGH: Efficient gene transfer into lymphoma cells using adenoviral vectors combined with lipofection. Cancer Gene Ther 2000, 7:1145-1155.
12. Meeker TC, Lay LT, Wroblewski JM, Turturro F, Li Z, Seth P: Adenoviral vectors efficiently target cell lines derived from selected lymphocytic malignancies, including anaplastic large cell lymphoma and Hodgkin's disease. Clin Cancer Res 1997, 3:357-364.
13. Turturro F, Heineke HL, Drevyanko TF, Link CJ, Seth P Jr: Adenovirus-p53-mediated gene therapy of anaplastic large cell lymphoma with t(2;5) in a nude mouse model. Gene Ther 2000, 7:930-933.
14. Huang MR, Olsson M, Kallin A, Pettersson U, Totterman TH: Efficient adenovirus-mediated gene transduction of normal and leukemic hematopoietic cells. Gene Ther 1997, 4:1093-1099.
15. Gonzalez R, Vereecque R, Wickham TJ, Vanrumbeke M, Kovesdi I, Bauters F, Fenaux P, Quesnel B: Increased gene transfer in acute myeloid leukemic cells by an adenovirus vector containing a modified fiber protein. Gene Ther 1999, 6:314-320.
16. Haddada H, Cordier L, Perricaudet M: Gene therapy using adenovirus vectors. Curr Top Microbiol Immunol 1995, 199:297-306.
17. Migliaccio AR, Bengra C, Ling J, Pi W, Li C, Zeng S, Keskintepe M, Whitney B, Sanchez M, Migliaccio G, Tuan D: Stable and unstable transgene integration sites in the human genome: extinction of the Green Fluorescent Protein transgene in K562 cells. Gene 2000, 256:197-214.
18. Baum C, Forster P, Hegewisch-Becker S, Harbers K: An optimized electroporation protocol applicable to a wide range of cell lines. Biotechniques 1994, 17:1058-1062.
19. Brielmeier M, Bechet JM, Falk MH, Pawlita M, Polack A, Bornkamm GW: Improving stable transfection efficiency: antioxidants dramatically improve the outgrowth of clones under dominant marker selection. Nucleic Acids Res 1998, 26:2082-2085.
20. Zelphati O, Wang Y, Kitada S, Reed JC, Felgner PL, Corbeil J: Intracellular Delivery of Proteins with a new lipid-mediated delivery system. J Biol Chem 2001, 276:35103-35110.
21. Lenz P, Bacot SM, Frazier-Jessen MR, Feldman GM.: Nucleoporation of dendritic cells: efficient gene transfer by electroporation into human monocyte-derived dendritic cells. FEBS Lett 2003, 538:149-154.
22. Fallaux FJ, Kranenburg O, Cramer SJ, Houweling A, Van Ormondt H, Hoeben RC, Van Der Eb AJ: Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Ther 1996, 7:215-222.
23. Graham FL, Prevec L: Methods for construction of adenovirus vectors. Mol Biotechnol 1995, 3:207-220.
24. Schakowski F, Gorschluter M, Junghans C, Schroff M, Buttgereit P, Ziske C, Schottker B, Konig-Merediz SA, Sauerbruch T, Wittig B, Schmidt-Wolf IGH: A novel minimal-size vector (midge) improves transgene expression in colon carcinoma cells and avoids transfection of undesired DNA. Mol Ther 2001, 3:793-800.
25. Hamm A, Krott N, Breibach I, Blindt R, Bosserhoff AK.: Efficient transfection method for primary cells. Tissue Eng 2002, 8(2):235-245.
26. Harriague J, Bismuth G: Imaging antigen-induced PI3K activation in T cells. Nat Immunol 2002, 3:1090-1096.
27. Zernecke A, Erl W, Fraemohs L, Lietz M, Weber C: Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction. Faseb J 2003, 17:1099-1101.
28. Buttgereit P, Schakowski F, Märten A, Brand K, Renoth S, Ziske C, Schöttker B, Ebert O, Schroers T, Schmidt-Wolf IGH: Effects of adenoviral wild-type p53 gene transfer in p53 mutated lymphoma cells. Cancer gene Ther 2001, 8(6):430-439.
29. Wills KN, Maneval DC, Menzel P, Harris MP, Sutjipto S, Vaillancourt MT, Huang WM, Johnson DE, Anderson SC, Wen SF et al.: Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. Hum Gene Ther 1994, 5:1079-1088.
30. Roddie PH, Paterson T, Turner ML: Gene transfer to primary acute myeloid leukaemia blasts and myeloid leukaemia cell lines. Cytokines Cell Mol Ther 2000, 6:127-134.
31. Van Tendeloo VF, Willems R, Ponsaerts P, Lenjou M, Nijs G, Vanhove M, Muylaert P, Van Cauwelaert P, Van Broeckhoven C, Van Bockstaele DR, Berneman ZN: High-level transgene expression in primary human T lymphocytes and adult bone marrow CD34+ cells via electroporation-mediated gene delivery. Gene Ther 2000, 7:1431-1437.
32. Estey EH: Treatment of acute myelogenous leukemia and myelodysplastic syndromes. Semin Hematol 1995, 32:132-151.
33. Horowitz MM, Gale RP, Sondel PM, Goldman JM, Kersey J, Kolb HJ, Rimm AA, Ringden O, Rozman C, Speck B et al.: Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990, 75:555-562.
34. O'Reilly RJ: Allogeneic bone marrow transplantation: current status and future directions. Blood 1983, 62:941-964.
35. Mayer RJ, Davis RB, Schiffer CA, Berg DT, Powell BL, Schulman P, Omura GA, Moore JO, McIntyre OR, Frei E 3rd: Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. N Engl J Med 1994, 331:896-903.
36. Bauduer F, Ducout L, Dastugue N, Capdupuy C, Renoux M: De novo and secondary acute myeloid leukemia in patients over the age of 65: a review of fifty-six successive and unselected cases from a general hospital. Leuk Lymphoma 1999, 35:289-296.
37. Ringden O, Sundberg B, Lonnqvist B, Tollemar J, Gahrton G, Nilsson B: Allogeneic bone marrow transplantation for leukemia: factors of importance for long-term survival and relapse. Bone Marrow Transplant 1988, 3:281-290.
38. Barrett AJ, Locatelli F, Treleaven JG, Gratwohl A, Szydlo R, Zwaan FE: Second transplants for leukaemic relapse after bone marrow transplantation: high early mortality but favourable effect of chronic GVHD on continued remission. A report by the EBMT Leukaemia Working Party. Br J Haematol 1991, 79:567-574.
39. Mrsic M, Horowitz MM, Atkinson K, Biggs JC, Champlin RE, Ehninger G, Gajewski JL, Gale RP, Herzig RH, Prentice HG et al.: Second HLA-identical sibling transplants for leukemia recurrence. Bone MarrowTransplant 1992, 9:269-275.
40. Gratwohl A, Hermans J, Apperley J, Arcese W, Bacigalupo A, Bandini G, di Bartolomeo P, Boogaerts M, Bosi A, Carreras E et al.: Acute graft-versus-host disease: grade and outcome in patients with chronic myelogenous leukemia. Working Party Chronic Leukemia of the European Group for Blood and Marrow Transplantation. Blood 1995, 86:813-818.
41. Kolb HJ, Schattenberg A, Goldman JM, Hertenstein B, Jacobsen N, Arcese W, Ljungman P, Ferrant A, Verdonck L, Niederwieser D et al.: Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Blood 1995, 86:2041-2050.
42. Kolb HJ, Holler E: Adoptive immunotherapy with donor lymphocyte transfusions. Curr Opin Oncol 1997, 9:139-145.
43. Szer J, Grigg AP, Phillips GL, Sheridan WP: Donor leucocyte infusions after chemotherapy for patients relapsing with acute leukaemia following allogeneic BMT. Bone Marrow Transplant 1993, 11:109-111.
44. Sievers EL, Appelbaum FR, Spielberger RT, Forman SJ, Flowers D, Smith FO, Shannon-Dorcy K, Berger MS, Bernstein ID: Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. Blood 1999, 93:3678-3684.
45. Trezise AE: In vivo DNA electrotransfer. DNA Cell Biol 2002, 21(12):869-877.