Functional rotation induced by alternating protonation states in the multidrug transporter AcrB: All-atom molecular dynamics simulations

Biochemistry

Volumn 52, Issue 43, 2013, Pages 7648-7658

  Yamane, Tsutomu ^a   Murakami, Satoshi ^b   Ikeguchi, Mitsunori ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC STRUCTURES; CONFORMATIONAL CHANGE; GRAM-NEGATIVE BACTERIA; MOLECULAR DYNAMICS SIMULATIONS; MULTIDRUG TRANSPORTERS; PROTON TRANSLOCATION; STRUCTURAL TRANSITIONS; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; INTERNATIONAL TRADE; MOLECULAR DYNAMICS; PROTONS; ROTATION;

PROTONATION;

MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG TRANSPORTER ACRB; UNCLASSIFIED DRUG;

ARTICLE; ATOM; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG TRANSPORT; FUNCTIONAL ROTATION; GRAM NEGATIVE BACTERIUM; LIPID BILAYER; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTON MOTIVE FORCE; PROTON TRANSPORT; STOICHIOMETRY;

ASPARTIC ACID; DATABASES, PROTEIN; ESCHERICHIA COLI PROTEINS; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHOSPHATIDYLETHANOLAMINES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; PROTON-MOTIVE FORCE; PROTONS;

EID: 84887111085     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400119v     Document Type: Article

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