Unidirectional peristaltic movement in multisite drug binding pockets of AcrB from molecular dynamics simulations

Molecular BioSystems

Volumn 8, Issue 10, 2012, Pages 2699-2709

  Feng, Zhiwei ^a   Hou, Tingjun ^a   Li, Youyong ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; NEGIBACTERIA;

ACRA PROTEIN, E COLI; ACRB PROTEIN, E COLI; ANTIINFECTIVE AGENT; CARRIER PROTEIN; ERYTHROMYCIN; ESCHERICHIA COLI PROTEIN; LIPOPROTEIN; MINOCYCLINE; MULTIDRUG RESISTANCE PROTEIN; OUTER MEMBRANE PROTEIN C; PORIN; RIFAMPICIN; WATER;

ARTICLE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ESCHERICHIA COLI; GENETICS; LIPID BILAYER; MOLECULAR DYNAMICS; MULTIDRUG RESISTANCE; MUTATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ERYTHROMYCIN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; LIPID BILAYERS; LIPOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MINOCYCLINE; MOLECULAR DYNAMICS SIMULATION; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PORINS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RIFAMPIN; WATER;

EID: 84865704280     PISSN: 1742206X     EISSN: 17422051     Source Type: Journal    
DOI: 10.1039/c2mb25184a     Document Type: Article

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