Sesamin induces cell cycle arrest and apoptosis through the inhibition of signal transducer and activator of transcription 3 signalling in human hepatocellular carcinoma cell line HepG2

Biological and Pharmaceutical Bulletin

Volumn 36, Issue 10, 2013, Pages 1540-1548

  Deng, Pengyi ^a   Wang, Chen ^a   Chen, Liulin ^a   Wang, Cheng ^a   Du, Yuhan ^a   Yan, Xu ^a   Chen, Mingjie ^a   Yang, Guangxiao ^a   He, Guangyuan ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Apoptosis; Cell cycle; HepG2 cell; Sesamin; Signal transducer and activator of transcription 3

Indexed keywords

CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; INTERLEUKIN 6; JANUS KINASE 2; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; PROTEIN P53; SESAMIN; STAT3 PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BAX GENE; BCL 2 GENE; BCL XL GENE; CANCER CELL CULTURE; CANCER INHIBITION; CDC2 GENE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYCLIN A GENE; CYCLIN B1 GENE; DRUG STRUCTURE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LIVER CELL CARCINOMA; P21 GENE; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL CYCLE CHECKPOINTS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DIOXOLES; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; INTERLEUKIN-6; LIGNANS; LIVER NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; SEEDS; SESAMUM; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84887056416     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b13-00235     Document Type: Article

References (35)

1. Lin YW, Chiang BH. 4-Acetylantroquinonol B isolated from Antrodia cinnamomea Arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels. J. Agric. Food Chem., 59, 8625-8631 (2011).
2. Bollrath J, Phesse TJ, Von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, Matthews V, Schmid RM, Kirchner T, Arkan MC, Ernst M, Greten FR. gp130-mediated STAT3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell, 15, 91-102 (2009).
3. Yu H, Jove R. The STATs of cancer - New molecular targets come of age. Nat. Rev. Cancer, 4, 97-105 (2004). (Pubitemid 38198738)
4. Darnell JE Jr. STATs and gene regulation. Science, 277, 1630-1635 (1997). (Pubitemid 27446219)
5. Reich NC, Liu L. Tracking STAT nuclear traffic. Nat. Rev. Immunol., 6, 602-612 (2006). (Pubitemid 44134093)
6. Bowman T, Garcia R, Turkson J, Jove R. STATs in oncogenesis. Oncogene, 19, 2474-2488 (2000). (Pubitemid 30339203)
7. Michaud-Levesque J, Bousquet-Gagnon N, Beliveau R. Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration. Exp. Cell Res., 318, 925-935 (2012).
8. Taga T, Kishimoto T. gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol., 15, 797-819 (1997). (Pubitemid 27169299)
9. Chung B-H, Lee JJ, Kim J-D, Jeoung D, Lee H, Choe J, Ha K-S, Kwon Y-G, Kim Y-M. Angiogenic activity of sesamin through the activation of multiple signal pathways. Biochem. Biophys. Res. Commun., 391, 254-260 (2010).
10. Hou RCW, Wu CC, Yang CH, Jeng KCG. Protective effects of sesamin and sesarnolin on murine BV-2 microglia cell line under hypoxia. Neurosci. Lett., 367, 10-13 (2004).
11. Fujikawa T, Kanada N, Shimada A, Ogata M, Suzuki I, Hayashi I, Nakashima K. Effect of sesamin in Acanthopanax senticosus HARMS on behavioral dysfunction in rotenone-induced Parkinsonian rats. Biol. Pharm. Bull., 28, 169-172 (2005). (Pubitemid 40879806)
12. Nakano D, Itoh C, Ishii F, Kawanishi H, Takaoka M, Kiso Y, Tsuruoka N, Tanaka T, Matsumura Y. Effects of sesamin on aortic oxidative stress and endothelial dysfunction in deoxycorticosterone acetate-salt hypertensive rats. Biol. Pharm. Bull., 26, 1701-1705 (2003). (Pubitemid 39663529)
13. Harikumar KB, Sung BY, Tharakan ST, Pandey MK, Joy B, Guha S, Krishnan S, Aggarwal BB. Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products. Mol. Cancer Res., 8, 751-761 (2010).
14. Kusaba M, Nakao K, Goto T, Nishimura D, Kawashimo H, Shibata H, Motoyoshi Y, Taura N, Ichikawa T, Hamasaki K, Eguchi K. Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis. J. Hepatol., 47, 546-555 (2007). (Pubitemid 47331746)
15. Kaina B. DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling. Biochem. Pharmacol., 66, 1547-1554 (2003). (Pubitemid 38373345)
16. Chan KT, Li K, Liu SL, Chu KH, Toh M, Xie WD. Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562. Cancer Lett., 289, 46-52 (2010).
17. Jing N, Tweardy DJ. Targeting STAT3 in cancer therapy. Anticancer Drugs, 16, 601-607 (2005). (Pubitemid 40863092)
18. Williams GH, Stoeber K. The cell cycle and cancer. J. Pathol., 226, 352-364 (2012).
19. Niu G, Wright KL, Ma Y, Wright GM, Huang M, Irby R, Briggs J, Karras J, Cress WD, Pardoll D, Jove R, Chen J, Yu H. Role of STAT3 in regulating p53 expression and function. Mol. Cell. Biol., 25, 7432-7440 (2005). (Pubitemid 41170107)
20. Giono LE, Manfredi JJ. The p53 tumor suppressor participates in multiple cell cycle checkpoints. J. Cell. Physiol., 209, 13-20 (2006). (Pubitemid 44318664)
21. St Clair S, Giono L, Varmeh-Ziaie S, Resnick-Silverman L, Liu WJ, Padi A, Dastidar J, Dacosta A, Mattia M, Manfredi JJ. DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: One involves direct binding to the cdc25C promoter. Mol. Cell, 16, 725-736 (2004). (Pubitemid 39586531)
22. Zhan Q, Antinore MJ, Wang XW, Carrier F, Smith ML, Harris CC, Forance AJ Jr. Association with Cdc2 and inhibition of Cdc2/cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene, 18, 2892-2900 (1999). (Pubitemid 29250879)
23. Cazzalini O, Scovassi AI, Savio M, Stivala LA, Prosperi E. Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response. Mutat. Res., 704, 12-20 (2010).
24. Hwang H, Kim C, Kim SM, Kim WS, Choi SH, Chang IM, Ahn KS. The hydrolyzed products of iridoid glycoside with β-glucosidase treatment exert anti-proliferative effects through suppression of STAT3 activation and STAT3-regulated gene products in several human cancer cells. Pharm. Biol., 50, 8-17 (2012).
25. Xiong H, Du W, Zhang YJ, Hong J, Su WY, Tang JT, Wang YC, Lu R, Fang JY. Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. Mol. Carcinog., 51, 174-184 (2012).
26. Kannaiyan R, Hay HS, Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Chng WJ, Sethi G. Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-kappa B and STAT3 regulated gene products in multiple myeloma cells. Br. J. Pharmacol., 164, 1506-1521 (2011).
27. Nakaya A, Sagawa M, Muto A, Uchida H, Ikeda Y, Kizaki M. The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-kappa B activity. Leuk. Res., 35, 243-249 (2011).
28. Weissenberger J, Priester M, Bernreuther C, Rakel S, Glatzel M, Seifert V, Kogel D. Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway. Clin. Cancer Res., 16, 5781-5795 (2010).
29. Chetty C, Dontula R, Ganji PN, Gujrati M, Lakka SS. SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells. Biochem. Biophys. Res. Commun., 417, 874-879 (2012).
30. Huang WW, Yang JS, Lin MW, Chen PY, Chiou SM, Chueh FS, Lan YH, Pai SJ, Tsuzuki M, Ho WJ, Chung JG. Cucurbitacin E induces G(2)/M phase arrest through STAT3/p53/p21 signaling and provokes apoptosis via fas/cd95 and mitochondria-dependent pathways in human bladder cancer T24 cells. Evid. Based Complement. Alternat. Med., 2012, 952762 (2012) 10.1155/2012/952762.
31. Yokota T, Matsuzaki Y, Koyama M, Hitomi T, Kawanaka M, Enoki-Konishi M, Okuyama Y, Takayasu J, Nishino H, Nishikawa A, Osawa T, Sakai T. Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells. Cancer Sci., 98, 1447-1453 (2007). (Pubitemid 47241769)
32. Zamzami N, Brenner C, Marzo I, Susin SA, Kroemer G. Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins. Oncogene, 16, 2265-2282 (1998). (Pubitemid 28220657)
33. Bhattacharya S, Ray RM, Johnson LR. STAT3-mediated transcription of Bcl-2, Mcl-1 and c-lAP2 prevents apoptosis in polyaminedepleted cells. Biochem. J., 392, 335-344 (2005). (Pubitemid 41796522)
34. Nielsen M, Kaestel CG, Eriksen KW, Woetmann A, Stokkedal T, Kaltoft K, Geisler C, Ropke C, Odum N. Inhibition of constitutively activated STAT3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells. Leukemia, 13, 735-738 (1999). (Pubitemid 29243625)
35. Liang ZW, Guo BF, Li Y, Li XJ, Li X, Zhao LJ, Gao LF, Yu H, Zhao XJ, Zhang L, Yang BX. Plasmid-based STAT3 siRNA delivered by hydroxyapatite nanoparticles suppresses mouse prostate tumour growth in vivo. Asian J. Androl., 13, 481-486 (2011).