SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells

Biochemical and Biophysical Research Communications

Volumn 417, Issue 2, 2012, Pages 874-879

  Chetty, Chandramu ^a   Dontula, Ranadheer ^a   Ganji, Purnachandra Nagaraju ^a   Gujrati, Meena ^a   Lakka, Sajani S ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Cell cycle; Medulloblastoma; SPARC; STAT3

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; COMPLEMENTARY DNA; CYCLIN B; CYCLIN DEPENDENT KINASE 1; OSTEONECTIN; PROTEIN P21; STAT3 PROTEIN;

ARTICLE; CANCER CELL; CANCER GROWTH; CANCER SIZE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL STRAIN; CONTROLLED STUDY; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MEDULLOBLASTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CEREBELLAR NEOPLASMS; HUMANS; MEDULLOBLASTOMA; MICE; OSTEONECTIN; STAT3 TRANSCRIPTION FACTOR; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS; MUS MUSCULUS;

EID: 84855840641     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.12.065     Document Type: Article

References (38)

1. Guessous F., Li Y., Abounader R. Signaling pathways in medulloblastoma. J. Cell. Physiol. 2008, 217:577-583.
2. Garzia L., Andolfo I., Cusanelli E., Marino N., Petrosino G., De Martino D., Esposito V., Galeone A., Navas L., Esposito S., Gargiulo S., Fattet S., Donofrio V., Cinalli G., Brunetti A., Vecchio L.D., Northcott P.A., Delattre O., Taylor M.D., Iolascon A., Zollo M. MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. PLoS ONE 2009, 4:e4998.
3. Kombogiorgas D., Sgouros S., Walsh A.R., Hockley A.D., Stevens M., Grundy R., Peet A., English M., Spooner D. Outcome of children with posterior fossa medulloblastoma: a single institution experience over the decade 1994-2003. Childs Nerv. Syst. 2007, 23:399-405.
4. Podhajcer O.L., Benedetti L., Girotti M.R., Prada F., Salvatierra E., Llera A.S. The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host. Cancer Metastasis Rev. 2008, 27:523-537.
5. Darnell J.E. Transcription factors as targets for cancer therapy. Nat. Rev. Cancer 2002, 2:740-749.
6. Bromberg J.F., Wrzeszczynska M.H., Devgan G., Zhao Y., Pestell R.G., Albanese C., Darnell J.E. Stat3 as an oncogene. Cell 1999, 98:295-303.
7. Garcia R., Yu C.L., Hudnall A., Catlett R., Nelson K.L., Smithgall T., Fujita D.J., Ethier S.P., Jove R. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ. 1997, 8:1267-1276.
8. Gouilleux-Gruart V., Gouilleux F., Desaint C., Claisse J.F., Capiod J.C., Delobel J., Weber-Nordt R., Dusanter-Fourt I., Dreyfus F., Groner B., Prin L. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 1996, 87:1692-1697.
9. Grandis J.R., Drenning S.D., Zeng Q., Watkins S.C., Melhem M.F., Endo S., Johnson D.E., Huang L., He Y., Kim J.D. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc. Natl Acad. Sci. USA 2000, 97:4227-4232.
10. Zhang F., Li C., Halfter H., Liu J. Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. Oncogene 2003, 22:894-905.
11. Alvarez J.V., Greulich H., Sellers W.R., Meyerson M., Frank D.A. Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer Res. 2006, 66:3162-3168.
12. Xiong H., Zhang Z.G., Tian X.Q., Sun D.F., Liang Q.C., Zhang Y.J., Lu R., Chen Y.X., Fang J.Y. Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia 2008, 10:287-297.
13. Bhoopathi P., Chetty C., Dontula R., Gujrati M., Dinh D.H., Rao J.S., Lakka S.S. SPARC stimulates neuronal differentiation of medulloblastoma cells via the notch1/STAT3 pathway. Cancer Res. 2011, 71:4908-4919.
14. R.A. Weinberg, Moving Out: Invasion and Metastasis, The Biology of Cancer, Garland Science, Taylor & Francis Group, LLC, New York, 2007, pp. 587-654.
15. Boutros R., Lobjois V., Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets?. Nat. Rev. Cancer 2007, 7:495-507.
16. Bhoopathi P., Chetty C., Gujrati M., Dinh D.H., Rao J.S., Lakka S.S. Cathepsin B facilitates autophagy mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells. Cell Death Differ. 2010, 17:1529-1539.
17. Rao J.S., Bhoopathi P., Chetty C., Gujrati M., Lakka S.S. Matrix metalloproteinase-9 short interfering RNA induced senescence resulting in inhibition of medulloblastoma growth via p16INK4 and mitogen-activated protein kinase pathway. Cancer Res. 2007, 67:4956-4964.
18. YH Choi, WH Lee, KY Park, Zhang L. p53-independent induction of p21 (WAF1/CIP1), reduction of Cyclin-B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells. Jpn. J. Cancer Res. 2000, 2:164-173.
19. Fukada T., Ohtani T., Yoshida Y., Shirogane T., Nishida K., Nakajima K., Hibi M., Hirano T. STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition. EMBO J. 1998, 17:6670-6677.
20. Catlett-Falcone R., Landowski T.H., Oshiro M.M., Turkson J., Levitzki A., Savino R., Ciliberto G., Moscinski L., Fernandez-Luna J.L., Nunez G., Dalton W.S., Jove R. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999, 10:105-115.
21. Lin Q., Lai R., Chirieac L.R., Li C., Thomazy V.A., Grammatikakis I., Rassidakis G.Z., Zhang W., Fujio Y., Kunisada K., Hamilton S.R., Amin H.M. Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am. J. Pathol. 2005, 167:969-980.
22. Tai I.T., Tang M.J. SPARC in cancer biology: its role in cancer progression and potential for therapy. Drug Resist. Update 2008, 11:231-246.
23. Massague J. TGF-beta signal transduction. Annu. Rev. Biochem. 1998, 67:753-791.
24. Dhanesuan N., Sharp J.A., Blick T., Price J.T., Thompson E.W. Doxycycline-inducible expression of SPARC/Osteonectin/BM40 in MDA-MB-231 human breast cancer cells results in growth inhibition. Breast Cancer Res. Treat 2002, 75:73-85.
25. Haber C.L., Gottifredi V., Llera A.S., Salvatierra E., Prada F., Alonso L., Sage E.H., Podhajcer O.L. SPARC modulates the proliferation of stromal but not melanoma cells unless endogenous SPARC expression is downregulated. Int. J. Cancer 2008, 122:1465-1475.
26. Said N., Socha M.J., Olearczyk J.J., Elmarakby A.A., Imig J.D., Motamed K. Normalization of the ovarian cancer microenvironment by SPARC. Mol. Cancer Res. 2007, 5:1015-1030.
27. +2-dependent binding to the extracellular matrix. J. Cell Biol. 1989, 109:341-356.
28. Funk S.E., Sage E.H. The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells. Proc. Natl Acad. Sci. USA 1991, 88:2648-2652.
29. Hoffmann I., Clarke P.R., Marcote M.J., Karsenti E., Draetta G. Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J. 1993, 12:53-63.
30. Hassan K.A., Ang K.K., El-Naggar A.K., Story M.D., Lee J.I., Liu D., Hong W.K., Mao L. Cyclin-B1 overexpression and resistance to radiotherapy in head and neck squamous cell carcinoma. Cancer Res. 2002, 62:6414-6417.
31. Li J.Q., Kubo A., Wu F., Usuki H., Fujita J., Bandoh S., Masaki T., Saoo K., Takeuchi H., Kobayashi S., Imaida K., Maeta H., Ishida T., Kuriyama S. Cyclin-B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes. Int. J. Oncol. 2003, 22:1101-1110.
32. Sarafan-Vasseur N., Lamy A., Bourguignon J., Le P.F., Hieter P., Sesboue R., Bastard C., Frebourg T., Flaman J.M. Overexpression of B-type cyclins alters chromosomal segregation. Oncogene 2002, 21:2051-2057.
33. Yuan J., Yan R., Kramer A., Eckerdt F., Roller M., Kaufmann M., Strebhardt K. Cyclin-B1 depletion inhibits proliferation and induces apoptosis in human tumor cells. Oncogene 2004, 23:5843-5852.
34. Pan X., Wang X., Lei W., Min L., Yang Y., Wang X., Song J. Nitric oxide suppresses transforming growth factor-beta1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology 2009, 50:1577-1587.
35. Barton B.E., Karras J.G., Murphy T.F., Barton A., Huang H.F. Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: direct STAT3 inhibition induces apoptosis in prostate cancer lines. Mol. Cancer Ther. 2004, 3:11-20.
36. Scholz A., Heinze S., Detjen K.M., Peters M., Welzel M., Hauff P., Schirner M., Wiedenmann B., Rosewicz S. Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Gastroenterology 2003, 125:891-905.
37. Klampfer L. Signal transducers and activators of transcription (STATs): novel targets of chemopreventive and chemotherapeutic drugs. Curr. Cancer Drug Targets 2006, 6:107-121.
38. Yu H., Jove R. The STATs of cancer - New molecular targets come of age. Nat. Rev. Cancer 2004, 4:97-105.