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Volumn 16, Issue 23, 2010, Pages 5781-5795

Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; GELATINASE B; JANUS KINASE 1; JANUS KINASE 2; KI 67 ANTIGEN; MYC PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST;

EID: 78650413780     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-0446     Document Type: Article
Times cited : (126)

References (53)
  • 1
    • 34250877865 scopus 로고    scopus 로고
    • Genetic pathways to primary and secondary glioblastoma
    • Ohgaki H, Kleihues P. Genetic pathways to primary and secondary glioblastoma. Am JPathol 2007;170:1445-53.
    • (2007) Am JPathol , vol.170 , pp. 1445-1453
    • Ohgaki, H.1    Kleihues, P.2
  • 2
    • 3042542580 scopus 로고    scopus 로고
    • Targeted therapy for brain tumours
    • Lesniak MS, Brem H. Targeted therapy for brain tumours. Nat Rev Drug Discov 2004;3:499-508.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 499-508
    • Lesniak, M.S.1    Brem, H.2
  • 3
    • 34748884398 scopus 로고    scopus 로고
    • Chemoradiotherapy in malignant glioma: Standard of care and future directions
    • Stupp R, Hegi ME, Gilbert MR, Chakravarti A. Chemoradiotherapy in malignant glioma: standard of care and future directions. J Clin Oncol 2007;25:4127-36.
    • (2007) J Clin Oncol , vol.25 , pp. 4127-4136
    • Stupp, R.1    Hegi, M.E.2    Gilbert, M.R.3    Chakravarti, A.4
  • 4
    • 56349116715 scopus 로고    scopus 로고
    • Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300
    • Ryu MJ, Cho M, Song JY, Yun YS, Choi IW, Kim DE, et al. Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochem Biophys Res Commun 2008;377:1304-8.
    • (2008) Biochem Biophys Res Commun , vol.377 , pp. 1304-1308
    • Ryu, M.J.1    Cho, M.2    Song, J.Y.3    Yun, Y.S.4    Choi, I.W.5    Kim, D.E.6
  • 5
    • 65649116571 scopus 로고    scopus 로고
    • Demethoxycurcumin induces Bcl-2 mediated G2/M arrest and apoptosis in human glioma U87 cells
    • Luthra PM, Kumar R, Prakash A. Demethoxycurcumin induces Bcl-2 mediated G2/M arrest and apoptosis in human glioma U87 cells. Biochem Biophy Res Commun 2009;384:420-5.
    • (2009) Biochem Biophy Res Commun , vol.384 , pp. 420-425
    • Luthra, P.M.1    Kumar, R.2    Prakash, A.3
  • 6
    • 34347221946 scopus 로고    scopus 로고
    • Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors
    • Dhandapani KM, Mahesh VB, Brann DW. Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factorsJ Neurochem 2007;102:522-38.
    • (2007) J Neurochem , vol.102 , pp. 522-538
    • Dhandapani, K.M.1    Mahesh, V.B.2    Brann, D.W.3
  • 7
    • 34347238938 scopus 로고    scopus 로고
    • Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: Role of Akt and extracellular signal-regulated kinase signaling pathways
    • Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol 2007;72:29-39.
    • (2007) Mol Pharmacol , vol.72 , pp. 29-39
    • Aoki, H.1    Takada, Y.2    Kondo, S.3    Sawaya, R.4    Aggarwal, B.B.5    Kondo, Y.6
  • 8
    • 26444458313 scopus 로고    scopus 로고
    • Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells
    • Kim SY, Jung SH, Kim HS. Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells. Biochem Biophys Res Commun 2005;337:510-6.
    • (2005) Biochem Biophys Res Commun , vol.337 , pp. 510-516
    • Kim, S.Y.1    Jung, S.H.2    Kim, H.S.3
  • 10
    • 51049123447 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3: A molecular hub for signaling pathways in gliomas
    • Brantley EC, Benveniste EN. Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol Cancer Res 2008;6:675-84.
    • (2008) Mol Cancer Res , vol.6 , pp. 675-684
    • Brantley, E.C.1    Benveniste, E.N.2
  • 12
    • 0034657958 scopus 로고    scopus 로고
    • Roles of STAT3 defined by tissue-specific gene targeting
    • Akira S. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 2000;19:2607-11.
    • (2000) Oncogene , vol.19 , pp. 2607-2611
    • Akira, S.1
  • 13
    • 0033198793 scopus 로고    scopus 로고
    • Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
    • Sano S, Itami S, Takeda K, Tarutani M, Yamaguchi Y, Miura H, et al. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J 1999;18:4657-68.
    • (1999) EMBO J , vol.18 , pp. 4657-4668
    • Sano, S.1    Itami, S.2    Takeda, K.3    Tarutani, M.4    Yamaguchi, Y.5    Miura, H.6
  • 14
    • 13444269249 scopus 로고    scopus 로고
    • Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
    • Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, et al. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 2005;11:43-9.
    • (2005) Nat Med , vol.11 , pp. 43-49
    • Sano, S.1    Chan, K.S.2    Carbajal, S.3    Clifford, J.4    Peavey, M.5    Kiguchi, K.6
  • 16
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove RSTATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009;9:798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 17
    • 21344436180 scopus 로고    scopus 로고
    • Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3
    • Schlessinger K, Levy DE. Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3. Cancer Res 2005;65:5828-34.
    • (2005) Cancer Res , vol.65 , pp. 5828-5834
    • Schlessinger, K.1    Levy, D.E.2
  • 19
    • 70350223977 scopus 로고    scopus 로고
    • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth
    • Wang H, Lathia JD, Wu Q, Wang J, Li Z, Heddleston JM, et al. Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells 2009;27:2393-404.
    • (2009) Stem Cells , vol.27 , pp. 2393-2404
    • Wang, H.1    Lathia, J.D.2    Wu, Q.3    Wang, J.4    Li, Z.5    Heddleston, J.M.6
  • 20
    • 0141955061 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducibleSTAT3 phosphorylation in human multiple myeloma cells
    • Bharti AC, Donato N, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducibleSTAT3 phosphorylation in human multiple myeloma cells. J Immunol 2003;171;3863-71.
    • (2003) J Immunol , vol.171 , pp. 3863-3871
    • Bharti, A.C.1    Donato, N.2    Aggarwal, B.B.3
  • 21
    • 3042748279 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells
    • Konnikova L, Kotecki M, Kruger MM, Cochran BH. Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC Cancer 2003;323.
    • (2003) BMC Cancer , pp. 323
    • Konnikova, L.1    Kotecki, M.2    Kruger, M.M.3    Cochran, B.H.4
  • 22
    • 34247154498 scopus 로고    scopus 로고
    • A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo
    • Iwamaru A, Szymanski S, Iwado E, Aoki H, Yokoyama T, Fokt I, et al. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene 2007;26:2435-44.
    • (2007) Oncogene , vol.26 , pp. 2435-2444
    • Iwamaru, A.1    Szymanski, S.2    Iwado, E.3    Aoki, H.4    Yokoyama, T.5    Fokt, I.6
  • 23
    • 34047198197 scopus 로고    scopus 로고
    • Orthotopic transplantation of v-src-expressing glioma cell lines into immunocompetent mice: Establishment of a new transplantable in vivo model for malignant glioma
    • Smilowitz HM, Weissenberger J, Weis J, Brown JD, O'Neill RJ, Laissue JA. Orthotopic transplantation of v-src-expressing glioma cell lines into immunocompetent mice: establishment of a new transplantable in vivo model for malignant glioma. J Neurosurg 2007;106:652-9.
    • (2007) J Neurosurg , vol.106 , pp. 652-659
    • Smilowitz, H.M.1    Weissenberger, J.2    Weis, J.3    Brown, J.D.4    O'Neill, R.J.5    Laissue, J.A.6
  • 24
  • 25
    • 17844396959 scopus 로고    scopus 로고
    • Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1
    • Loeffler S, Fayard B, Weis J, Weissenberger J. Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1. Int J Cancer 2005;115:202-13.
    • (2005) Int J Cancer , vol.115 , pp. 202-213
    • Loeffler, S.1    Fayard, B.2    Weis, J.3    Weissenberger, J.4
  • 26
    • 79952189765 scopus 로고    scopus 로고
    • Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells
    • Epub ahead of print
    • Senft C, Priester M, Polacin M, Schroder K, Seifert V, Kogel D, et al. Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells. J Neurooncol. [Epub ahead of print].
    • J Neurooncol
    • Senft, C.1    Priester, M.2    Polacin, M.3    Schroder, K.4    Seifert, V.5    Kogel, D.6
  • 28
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 29
    • 67650306400 scopus 로고    scopus 로고
    • Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects
    • Hekmatara T, Bernreuther C, Khalansky AS, Theisen A, Weissenberger J, Matschke J, et al. Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects. Clin Neuropathol 2009;28: 153-64.
    • (2009) Clin Neuropathol , vol.28 , pp. 153-164
    • Hekmatara, T.1    Bernreuther, C.2    Khalansky, A.S.3    Theisen, A.4    Weissenberger, J.5    Matschke, J.6
  • 31
    • 33947417336 scopus 로고    scopus 로고
    • Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: Clinical implications
    • Huang S. Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin Cancer Res 2007;13:1362-6.
    • (2007) Clin Cancer Res , vol.13 , pp. 1362-1366
    • Huang, S.1
  • 33
    • 0042941403 scopus 로고    scopus 로고
    • Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet
    • Yang W, Bancroft L, Nicholas C, Lozonschi I, Augenlicht LH. Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet. Cancer Res 2003;63:4990-6.
    • (2003) Cancer Res , vol.63 , pp. 4990-4996
    • Yang, W.1    Bancroft, L.2    Nicholas, C.3    Lozonschi, I.4    Augenlicht, L.H.5
  • 34
    • 0031022228 scopus 로고    scopus 로고
    • Dietary fat and colon cancer: Modulating effect of types and amount of dietary fat on ras-p21 function during promotion and progression stages of colon cancer
    • Singh J, Hamid R, Reddy BS. Dietary fat and colon cancer: modulating effect of types and amount of dietary fat on ras-p21 function during promotion and progression stages of colon cancer. Cancer Res 1997;57:253-8.
    • (1997) Cancer Res , vol.57 , pp. 253-258
    • Singh, J.1    Hamid, R.2    Reddy, B.S.3
  • 35
    • 0034612289 scopus 로고    scopus 로고
    • Glioblastoma multiforme: The terminator
    • Holland EC. Glioblastoma multiforme: the terminator. Proc Natl Acad Sci USA 2000;97:6242-4.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6242-6244
    • Holland, E.C.1
  • 36
    • 0141923853 scopus 로고    scopus 로고
    • Is the long-term survival of patients with intracranial glioblastoma multiforme overstated?
    • McLendon RE, Halperin EC. Is the long-term survival of patients with intracranial glioblastoma multiforme overstated?Cancer 2003;98:1745-8.
    • (2003) Cancer , vol.98 , pp. 1745-1748
    • McLendon, R.E.1    Halperin, E.C.2
  • 37
    • 70349651898 scopus 로고    scopus 로고
    • Very late relapses in glioblastoma long-term survivors
    • Bahr O, Herrlinger U, Weller M, Steinbach JP. Very late relapses in glioblastoma long-term survivors. J Neurol 2009;256:1756-8.
    • (2009) J Neurol , vol.256 , pp. 1756-1758
    • Bahr, O.1    Herrlinger, U.2    Weller, M.3    Steinbach, J.P.4
  • 38
    • 75149195336 scopus 로고    scopus 로고
    • The transcriptional network for mesenchymal transformation of brain tumours
    • Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY, et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 2010;463: 318-25.
    • (2010) Nature , vol.463 , pp. 318-325
    • Carro, M.S.1    Lim, W.K.2    Alvarez, M.J.3    Bollo, R.J.4    Zhao, X.5    Snyder, E.Y.6
  • 40
    • 40349111099 scopus 로고    scopus 로고
    • Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition
    • Borghouts C, Kunz C, Delis N, Groner B. Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition. Mol Cancer Res 2008;6:267-81.
    • (2008) Mol Cancer Res , vol.6 , pp. 267-281
    • Borghouts, C.1    Kunz, C.2    Delis, N.3    Groner, B.4
  • 42
    • 33846491404 scopus 로고    scopus 로고
    • NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition
    • La Ferla-Bruhl K, Westhoff MA, Karl S, Kasperczyk H, Zwacka RM, Debatin KM, et al. NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition. Oncogene 2007;26: 571-82.
    • (2007) Oncogene , vol.26 , pp. 571-582
    • La Ferla-Bruhl, K.1    Westhoff, M.A.2    Karl, S.3    Kasperczyk, H.4    Zwacka, R.M.5    Debatin, K.M.6
  • 43
    • 0345016388 scopus 로고    scopus 로고
    • Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia
    • Kim HY, Park EJ, Joe EH, Jou I. Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia. J Immunol 2003;171:6072-9.
    • (2003) J Immunol , vol.171 , pp. 6072-6079
    • Kim, H.Y.1    Park, E.J.2    Joe, E.H.3    Jou, I.4
  • 44
    • 58649101347 scopus 로고    scopus 로고
    • gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    • Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer cell 2009; 15:91-102.
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1    Phesse, T.J.2    Von Burstin, V.A.3    Putoczki, T.4    Bennecke, M.5    Bateman, T.6
  • 45
    • 69249221254 scopus 로고    scopus 로고
    • Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
    • Sullivan NJ, Sasser AK, Axel AE, Vesuna F, Raman V, Ramirez N, et al. Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 2009;28:2940-7.
    • (2009) Oncogene , vol.28 , pp. 2940-2947
    • Sullivan, N.J.1    Sasser, A.K.2    Axel, A.E.3    Vesuna, F.4    Raman, V.5    Ramirez, N.6
  • 48
    • 0032926620 scopus 로고    scopus 로고
    • Biotransformation of curcumin through reduction and glucuronidation in mice
    • Pan MH, Huang TM, Lin JK. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab Dispos 1999;27:486-94.
    • (1999) Drug Metab Dispos , vol.27 , pp. 486-494
    • Pan, M.H.1    Huang, T.M.2    Lin, J.K.3
  • 50
    • 33845906840 scopus 로고    scopus 로고
    • Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity
    • Learn CA, Grossi PM, Schmittling RJ, Xie W, Mitchell DA, Karikari I, et al. Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. J Neuroimmunol 2007;182:63-72.
    • (2007) J Neuroimmunol , vol.182 , pp. 63-72
    • Learn, C.A.1    Grossi, P.M.2    Schmittling, R.J.3    Xie, W.4    Mitchell, D.A.5    Karikari, I.6
  • 51
    • 70349097179 scopus 로고    scopus 로고
    • Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice
    • Zhang L, Alizadeh D, Van Handel M, Kortylewski M, Yu H, Badie B. Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice. Glia 2009;57:1458-67.
    • (2009) Glia , vol.57 , pp. 1458-1467
    • Zhang, L.1    Alizadeh, D.2    Van Handel, M.3    Kortylewski, M.4    Yu, H.5    Badie, B.6
  • 52
    • 42149111675 scopus 로고    scopus 로고
    • Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma
    • Fujita M, Zhu X, Sasaki K, Ueda R, Low KL, Pollack IF, et al. Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma. J Immunol 2008;180:2089-98.
    • (2008) J Immunol , vol.180 , pp. 2089-2098
    • Fujita, M.1    Zhu, X.2    Sasaki, K.3    Ueda, R.4    Low, K.L.5    Pollack, I.F.6
  • 53
    • 58149084882 scopus 로고    scopus 로고
    • A Pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of curcumin
    • Antony B, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A Pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of curcumin. Indian J Pharm Sci 2008;70:445-9.
    • (2008) Indian J Pharm Sci , vol.70 , pp. 445-449
    • Antony, B.1    Merina, B.2    Iyer, V.S.3    Judy, N.4    Lennertz, K.5    Joyal, S.6


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