Rutin inhibits B[a]PDE-induced cyclooxygenase-2 expression by targeting EGFR kinase activity

Biochemical Pharmacology

Volumn 86, Issue 10, 2013, Pages 1468-1475

  Choi, Seunghwan ^a   Lim, Tae Gyu ^b,c   Hwang, Mun Kyung ^b   Kim, Yoon A ^b   Kim, Jiyoung ^b,c   Kang, Nam Joo ^d   Jang, Tae Su ^e   Park, Jun Seong ^f   Yeom, Myeong Hun ^f   Lee, Ki Won ^a,b,c  

^a Konkuk University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

^d Kyungpook National University   (South Korea)

^e Seoul National University   (South Korea)

^f AmorePacific Corporation   (South Korea)

Author keywords

Benzo a pyrene 7,8 diol 9,10 epoxide; Cyclooxygenase 2; EGFR; Rutin; Signaling pathway

Indexed keywords

7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; ADENOSINE TRIPHOSPHATE; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE B; RAF PROTEIN; RUTOSIDE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATTENUATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG PROTEIN BINDING; DRUG TARGETING; EMBRYO CELL; ENZYME ACTIVITY; FIBROBLAST; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

BENZO[A]PYRENE-7,8-DIOL-9,10-EPOXIDE; CYCLOOXYGENASE-2; EGFR; RUTIN; SIGNALING PATHWAY;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANIMALS; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; ENVIRONMENTAL POLLUTANTS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; MICE; MICE, KNOCKOUT; NF-KAPPA B; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RAF KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RUTIN; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC;

EID: 84887037698     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.08.066     Document Type: Article

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