Vasorelaxant and hypotensive effects of the extract and the isolated flavonoid rutin obtained from Polygala paniculata L.

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 6, 2011, Pages 875-881

  Da Rocha Lapa, Fernanda ^a   Soares, Kelly Cristina ^a   Rattmann, Yanna Dantas ^a   Crestani, Sandra ^a   Missau, Fabiana Cristina ^b   Pizzolatti, Moacir Geraldo ^b   Marques, Maria Consuelo Andrade ^a   Rieck, Lia ^a   Santos, Adair Roberto Soares ^a,b  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

hypotensive; nitric oxide; polygala paniculata; rutin; vasorelaxant

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANTIHYPERTENSIVE AGENT; ATROPINE; CHARYBDOTOXIN; CHOLINERGIC RECEPTOR; CYCLIC GMP; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; MEPYRAMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PLANT EXTRACT; POLYGALA PANICULATA EXTRACT; POTASSIUM CHANNEL; RUTOSIDE; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; POLYGALA PANICULATA; POLYGALACEAE; RAT; THORACIC AORTA; VASCULAR RING; VASODILATATION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA; ATROPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GUANYLATE CYCLASE; MALE; METHYLENE BLUE; NG-NITROARGININE METHYL ESTER; PHYTOTHERAPY; PLANT EXTRACTS; POLYGALA; POTASSIUM CHANNEL BLOCKERS; PYRILAMINE; RATS; RATS, WISTAR; RUTIN; VASODILATOR AGENTS;

EID: 79956206256     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2010.01240.x     Document Type: Article

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