Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK and p70s6k-dependent pathway promotes cell transformation and tumorigenesis

Journal of Biological Chemistry

Volumn 284, Issue 48, 2009, Pages 33311-33319

  Ding, Jin ^a   Ning, Beifang ^b   Gong, Wenfeng ^a   Wen, Wen ^a   Wu, Kun ^a   Liang, Junqing ^a   He, Guoping ^a   Huang, Shanna ^a   Sun, Wen ^a   Han, Tao ^a   Huang, Lei ^a   Cao, Guangwen ^a   Wu, Mengchao ^a   Xie, Weifen ^b   Wang, Hongyang ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B CELLS; BENZO [A] PYRENE; CARCINOGENIC EFFECTS; CELL TRANSFORMATION; CHEMICAL INHIBITORS; CHEMOPREVENTION; CYCLIND1; DOMINANT-NEGATIVE MUTANTS; EPITHELIAL CELLS; ERK ACTIVATION; HEPATOCYTES; HUMAN CANCER; MOLECULAR MECHANISM; ONCOGENIC TRANSFORMATION; OVER-EXPRESSION; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3-KINASE; PRE-TREATMENT; REGULATORY SUBUNITS; TUMORIGENESIS;

PARTIAL DIFFERENTIAL EQUATIONS; TISSUE CULTURE;

AIRCRAFT ENGINES;

BENZO[A]PYRENE 7,8 DIHYDRODIOL 9,10 OXIDE; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P70; RAPAMYCIN; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CARCINOGENESIS; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LIVER CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLOTTING, WESTERN; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; EPITHELIAL CELLS; GENE EXPRESSION; HEPATOCYTES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, NUDE; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS, EXPERIMENTAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 70450277163     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.046417     Document Type: Article

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