-
2
-
-
18044364816
-
Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts
-
Liu, J., Qu, R., Ogura, M., Shibata, T., Harada, H. and Hiraoka, M. (2005) Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts. J. Radiat. Res. 46: 93-102.
-
(2005)
J. Radiat. Res.
, vol.46
, pp. 93-102
-
-
Liu, J.1
Qu, R.2
Ogura, M.3
Shibata, T.4
Harada, H.5
Hiraoka, M.6
-
4
-
-
0030744115
-
Radiation, hypoxia and genetic stimulation: Implications for future therapies
-
Adams, G. E., Kasan, N. M. and Joiner, M. C. (1997) Radiation, hypoxia and genetic stimulation: implications for future therapies. Radiother. Oncol. 44: 101-109.
-
(1997)
Radiother. Oncol.
, vol.44
, pp. 101-109
-
-
Adams, G.E.1
Kasan, N.M.2
Joiner, M.C.3
-
5
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
Hockel, M., Schlenger, K., Aral, B., Mitze, M., Schaffer, U. and Vaupel P. (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix, Cancer Res. 56: 4509-4515.
-
(1996)
Cancer Res.
, vol.56
, pp. 4509-4515
-
-
Hockel, M.1
Schlenger, K.2
Aral, B.3
Mitze, M.4
Schaffer, U.5
Vaupel, P.6
-
6
-
-
0030022252
-
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
-
Brizel DM., Scully SP., Harrelson JM., Layfield LJ., Bean JM., Prosnitz LR. and Dewhirst MW. (1996) Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma, Cancer Res. 56: 941-943.
-
(1996)
Cancer Res.
, vol.56
, pp. 941-943
-
-
Brizel, D.M.1
Scully, S.P.2
Harrelson, J.M.3
Layfield, L.J.4
Bean, J.M.5
Prosnitz, L.R.6
Dewhirst, M.W.7
-
7
-
-
0024384825
-
Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: Report from the DAHANCA 2 study
-
Overgaard, J., Hansen, H. S., Andersen, A. P., Hjelm-Hansen, M., Jorgensen, K., Sandberg, E., Berthelsen, A., Hammer, R. and Pedersen, M. (1989) Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: report from the DAHANCA 2 study. Int. J. Radiat. Oncol. Biol. Phys. 16: 1065-1068.
-
(1989)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.16
, pp. 1065-1068
-
-
Overgaard, J.1
Hansen, H.S.2
Andersen, A.P.3
Hjelm-Hansen, M.4
Jorgensen, K.5
Sandberg, E.6
Berthelsen, A.7
Hammer, R.8
Pedersen, M.9
-
8
-
-
0026606038
-
Radiosensitization by 2-nitroimidazole nucleoside analog RP-170: Radiosensitizing effects under both intravenous and oral administration
-
Murayama, C., Suzuki, A., Sato, C., Tanabe, Y., Miyata, Y., Shoji, T., Suzuki, T., Sakaguchi, M. and Mori, T. (1992) Radiosensitization by 2-nitroimidazole nucleoside analog RP-170: radiosensitizing effects under both intravenous and oral administration. Int. J. Radiat. Oncol. Biol. Phys. 22: 557-560.
-
(1992)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.22
, pp. 557-560
-
-
Murayama, C.1
Suzuki, A.2
Sato, C.3
Tanabe, Y.4
Miyata, Y.5
Shoji, T.6
Suzuki, T.7
Sakaguchi, M.8
Mori, T.9
-
9
-
-
0027177156
-
Radiosensitization by a new potent nucleoside analog: 1-(1',3',4'-trihydroxy-2'-butoxy)methyl-2-nitroimidazole (RP-343)
-
Murayama, C., Suzuki, A., Sato, C., Tanabe, Y., Shoji, T., Miyata, Y., Nishio, A., Suzuki, T., Sakaguchi, M. and Mori, T. (1993) Radiosensitization by a new potent nucleoside analog: 1-(1',3',4'-trihydroxy-2'-butoxy)methyl-2- nitroimidazole (RP-343). Int. J. Radiat. Oncol. Biol. Phys. 26: 433-443.
-
(1993)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.26
, pp. 433-443
-
-
Murayama, C.1
Suzuki, A.2
Sato, C.3
Tanabe, Y.4
Shoji, T.5
Miyata, Y.6
Nishio, A.7
Suzuki, T.8
Sakaguchi, M.9
Mori, T.10
-
10
-
-
0030854147
-
Results of a European randomized trial of Etanidazole combined with radiotherapy in head and neck carcinomas
-
Eschwege, F., Sancho-Garnier, H., Chassagne, D., Brisgand, D., Guerra, M., Malaise, E.P., Bey, P., Busutti, L., Cionini, L., N'Guyen, T., Romanini, A., Chavaudra, J. and Hill, C. (1997) Results of a European randomized trial of Etanidazole combined with radiotherapy in head and neck carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 39: 275-281.
-
(1997)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.39
, pp. 275-281
-
-
Eschwege, F.1
Sancho-Garnier, H.2
Chassagne, D.3
Brisgand, D.4
Guerra, M.5
Malaise, E.P.6
Bey, P.7
Busutti, L.8
Cionini, L.9
N'Guyen, T.10
Romanini, A.11
Chavaudra, J.12
Hill, C.13
-
11
-
-
0031909654
-
A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
-
Overgaard, J., Hansen, H. S., Overgaard, M., Bastholt, L., Berthelsen, A., Specht, L., Lindelov, B. and Jorgensen K. (1998) A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother. Oncol. 46: 135-146.
-
(1998)
Radiother. Oncol.
, vol.46
, pp. 135-146
-
-
Overgaard, J.1
Hansen, H.S.2
Overgaard, M.3
Bastholt, L.4
Berthelsen, A.5
Specht, L.6
Lindelov, B.7
Jorgensen, K.8
-
12
-
-
0030200968
-
A Phase i study of a hypoxic cell sensitizer KU-2285 in combination with conventional radiotherapy
-
Shibamoto, Y., Takahashi, M. and Abe, M. (1996) A Phase I study of a hypoxic cell sensitizer KU-2285 in combination with conventional radiotherapy. Radiother. Oncol. 40: 55-58.
-
(1996)
Radiother. Oncol.
, vol.40
, pp. 55-58
-
-
Shibamoto, Y.1
Takahashi, M.2
Abe, M.3
-
13
-
-
0030727814
-
A phase I/II study of a hypoxic cell radiosensitizer KU-2285 in combination with intraoperative radiotherapy
-
Shibamoto, Y., Ohshio, G., Hosotani, R., Nishimura, Y., Manabe, T., Imamura, M. and Abe, M. (1997) A phase I/II study of a hypoxic cell radiosensitizer KU-2285 in combination with intraoperative radiotherapy. Brit. J. Cancer. 76: 1474-1479.
-
(1997)
Brit. J. Cancer
, vol.76
, pp. 1474-1479
-
-
Shibamoto, Y.1
Ohshio, G.2
Hosotani, R.3
Nishimura, Y.4
Manabe, T.5
Imamura, M.6
Abe, M.7
-
14
-
-
0011305162
-
Hypoxic cell radiosensitizers: The end of an era?
-
Regarding Lee et al.
-
Brown JM. (1995) Hypoxic cell radiosensitizers: the end of an era? Regarding Lee et al., IJROBP 32: 567-576
-
(1995)
IJROBP
, vol.32
, pp. 567-576
-
-
Brown, J.M.1
-
16
-
-
10644256629
-
The Japanese experiences with hypoxia-targeting pharmacoradio-therapy: From hypoxic cell sensitisers to radiation-activated prodrugs
-
Shibamoto, Y., Sugie, C., Ito, M. and Ogino, H. (2004) The Japanese experiences with hypoxia-targeting pharmacoradio-therapy: from hypoxic cell sensitisers to radiation-activated prodrugs. Expert Opin. Pharmacother. 5: 2459-2467.
-
(2004)
Expert Opin. Pharmacother.
, vol.5
, pp. 2459-2467
-
-
Shibamoto, Y.1
Sugie, C.2
Ito, M.3
Ogino, H.4
-
17
-
-
0024363529
-
Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers
-
Shibamoto, Y., Nishimoto, S., Shimokawa, K., Hisanaga, Y., Zhou, L., Wang, J., Sasai, K., Takahashi, M., Abe, M. and Kagiya, T. (1989) Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers. Int. J. Radiat. Oncol. Biol. Phys. 16: 1045-1048.
-
(1989)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.16
, pp. 1045-1048
-
-
Shibamoto, Y.1
Nishimoto, S.2
Shimokawa, K.3
Hisanaga, Y.4
Zhou, L.5
Wang, J.6
Sasai, K.7
Takahashi, M.8
Abe, M.9
Kagiya, T.10
-
18
-
-
0025895726
-
A fluorinated 2-nitroimidazole, KU-2285, as a new hypoxic cell radiosensitizer
-
Sasai, K., Nishimoto, S., Shimokawa, K., Hisanaga, Y., Kitakabu, Y., Shibamoto, Y., Zhou, L., Wang, J., Takahashi, M., Kagiya, T. and Abe, M. (1991) A fluorinated 2-nitroimidazole, KU-2285, as a new hypoxic cell radiosensitizer. Int. J. Radiat. Oncol. Biol. Phys. 20: 1249-1254.
-
(1991)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.20
, pp. 1249-1254
-
-
Sasai, K.1
Nishimoto, S.2
Shimokawa, K.3
Hisanaga, Y.4
Kitakabu, Y.5
Shibamoto, Y.6
Zhou, L.7
Wang, J.8
Takahashi, M.9
Kagiya, T.10
Abe, M.11
-
19
-
-
0026056373
-
In vivo radiosensitizing activity of a new fluorinated hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation
-
Sasai, K., Fushiki, M., Yukawa, Y., Suyama, S., Iwai, H., Shibamoto, Y., Nishimoto, S., Takahashi, M. and Abe, M. (1991) In vivo radiosensitizing activity of a new fluorinated hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation. Int. T. Radiat. Oncol. Biol. Phys. 21: 1231-1234.
-
(1991)
Int. T. Radiat. Oncol. Biol. Phys.
, vol.21
, pp. 1231-1234
-
-
Sasai, K.1
Fushiki, M.2
Yukawa, Y.3
Suyama, S.4
Iwai, H.5
Shibamoto, Y.6
Nishimoto, S.7
Takahashi, M.8
Abe, M.9
-
20
-
-
0027370858
-
In vivo radiosensitization efficacy of KU-2285 and etanidazole at clinically relevant low radiation doses
-
Oya, N., Shibamoto, Y., Sasai, K., Sugiyama, T. and Abe, M. (1993) In vivo radiosensitization efficacy of KU-2285 and etanidazole at clinically relevant low radiation doses. Int. J. Radiat. Oncol. Biol. Phys. 27: 1113-1119.
-
(1993)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.27
, pp. 1113-1119
-
-
Oya, N.1
Shibamoto, Y.2
Sasai, K.3
Sugiyama, T.4
Abe, M.5
-
21
-
-
0026778985
-
Pharmacokinetics of fluorinated 2-nitroimidazole hypoxic cell radiosensitizers in murine peripheral nervous tissue
-
Sasai, K., Iwai, H., Yoshizawa, T., Nishimoto, S., Shibamoto, Y., Kitakabu, Y., Oya, N., Takahashi, M. and Abe, M. (1992) Pharmacokinetics of fluorinated 2-nitroimidazole hypoxic cell radiosensitizers in murine peripheral nervous tissue. Int. J. Radiat. Biol. 62: 221-227.
-
(1992)
Int. J. Radiat. Biol.
, vol.62
, pp. 221-227
-
-
Sasai, K.1
Iwai, H.2
Yoshizawa, T.3
Nishimoto, S.4
Shibamoto, Y.5
Kitakabu, Y.6
Oya, N.7
Takahashi, M.8
Abe, M.9
-
22
-
-
0035122495
-
Phase Ia study of a hypoxic cell sensitizer doranidazole (PR-350) in combination with conventional radiotherapy
-
Nemoto, K., Shibamoto, Y., Ohmagari, J., Baba, Y., Ebe, K., Ariga, H., Takai, Y., Ouchi, A., Sasai, K., Shinozaki, M., Tsujitani, M., Sakaguchi, M., Yamada, S. and Sakamoto, K. (2001) Phase Ia study of a hypoxic cell sensitizer doranidazole (PR-350) in combination with conventional radiotherapy. Anti-Cancer Drugs. 12: 1-6.
-
(2001)
Anti-cancer Drugs.
, vol.12
, pp. 1-6
-
-
Nemoto, K.1
Shibamoto, Y.2
Ohmagari, J.3
Baba, Y.4
Ebe, K.5
Ariga, H.6
Takai, Y.7
Ouchi, A.8
Sasai, K.9
Shinozaki, M.10
Tsujitani, M.11
Sakaguchi, M.12
Yamada, S.13
Sakamoto, K.14
-
23
-
-
1842587450
-
Phase III trial of radiosensitizer PR-350 combined with intraoperative radiotherapy for the treatment of locally advanced pancreatic cancer
-
Sunamura, M., Karasawa, K., Okamoto, A., Ogata, Y., Nemoto, K., Hosotani, R., Nishimura, Y., Matsui, K., Matsuno, S. (2004) Phase III trial of radiosensitizer PR-350 combined with intraoperative radiotherapy for the treatment of locally advanced pancreatic cancer. Pancreas. 28: 330-334.
-
(2004)
Pancreas
, vol.28
, pp. 330-334
-
-
Sunamura, M.1
Karasawa, K.2
Okamoto, A.3
Ogata, Y.4
Nemoto, K.5
Hosotani, R.6
Nishimura, Y.7
Matsui, K.8
Matsuno, S.9
-
24
-
-
0009844961
-
Biologic basis of radiation oncology
-
Eds. L. L. Gunderson and J. E. Tepper, Churchill Livingstone, New York, Edinburgh, London, Philadelphia
-
Zeman E. M. (2000) Biologic basis of radiation oncology. In: Clinical Radiation Oncology, Eds. L. L. Gunderson and J. E. Tepper, pp. 1-41, Churchill Livingstone, New York, Edinburgh, London, Philadelphia.
-
(2000)
Clinical Radiation Oncology
, pp. 1-41
-
-
Zeman, E.M.1
-
25
-
-
0020405282
-
A comparative investigation of nimorazole and misonidazole as hypoxic radiosensitizers in a C3H mammary carcinoma in vivo
-
Overgaard, J., Overgaard, M., Nielsen, O. S., Pedersen, A. K. and Timothy, A. R. (1982) A comparative investigation of nimorazole and misonidazole as hypoxic radiosensitizers in a C3H mammary carcinoma in vivo. Brit. J. Cancer. 46: 904-911.
-
(1982)
Brit. J. Cancer
, vol.46
, pp. 904-911
-
-
Overgaard, J.1
Overgaard, M.2
Nielsen, O.S.3
Pedersen, A.K.4
Timothy, A.R.5
-
26
-
-
0022515548
-
Radiosensitization in vitro and in vivo by 3-nitrotriazoles
-
Shibamoto, Y., Sakano, K., Kimura, R., Nishidai, T., Nishimoto, S., Ono, K., Kagiya, T. and Abe, M. (1986) Radiosensitization in vitro and in vivo by 3-nitrotriazoles. Int. J. Radiat. Oncol. Biol. Phys. 12: 1063-1066.
-
(1986)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.12
, pp. 1063-1066
-
-
Shibamoto, Y.1
Sakano, K.2
Kimura, R.3
Nishidai, T.4
Nishimoto, S.5
Ono, K.6
Kagiya, T.7
Abe, M.8
-
27
-
-
2942548201
-
Radiosensitizer sanazole (AK-2123) enhances gamma-radiation-induced apoptosis in murine fibrosarcoma
-
Rajagopalan, R., Kagiya, T. V. and Nair, C. K. (2003) Radiosensitizer sanazole (AK-2123) enhances gamma-radiation-induced apoptosis in murine fibrosarcoma. J. Radiat. Res. 44: 359-365.
-
(2003)
J. Radiat. Res.
, vol.44
, pp. 359-365
-
-
Rajagopalan, R.1
Kagiya, T.V.2
Nair, C.K.3
-
28
-
-
0007477263
-
Effect of a hypoxic radiosensitizer, AK 2123 (Sanazole), on yeast Saccharomyces cerevisiae
-
Pasupathy, K., Nair, C. K. and Kagiya, T. V. (2001) Effect of a hypoxic radiosensitizer, AK 2123 (Sanazole), on yeast Saccharomyces cerevisiae. J. Radiat. Res. 42: 217-227.
-
(2001)
J. Radiat. Res.
, vol.42
, pp. 217-227
-
-
Pasupathy, K.1
Nair, C.K.2
Kagiya, T.V.3
-
29
-
-
7444255953
-
Preparation and preliminary biological evaluation of a 177Lu labeled sanazole derivative for possible use in targeting tumor hypoxia
-
Das T., Chakraborty S., Banerjee S., Mukherjee A., Samuel G., Sarma HD., Nair CK., Kagiya VT., Venkatesh M. (2004) Preparation and preliminary biological evaluation of a 177Lu labeled sanazole derivative for possible use in targeting tumor hypoxia. Bioorg. Med. Chem. 12: 6077-6084.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, pp. 6077-6084
-
-
Das, T.1
Chakraborty, S.2
Banerjee, S.3
Mukherjee, A.4
Samuel, G.5
Sarma, H.D.6
Nair, C.K.7
Kagiya, V.T.8
Venkatesh, M.9
-
30
-
-
17244377371
-
Radiomodulatory effect of liposome encapsulated AK-2123 on tumor in mice exposed to hepatocarcinogen
-
Alam A., Rapthap CC., Singha LI., Sharan RN., Singh V. (2005) Radiomodulatory effect of liposome encapsulated AK-2123 on tumor in mice exposed to hepatocarcinogen. Mol. Chem. Biochem. 271: 139-150.
-
(2005)
Mol. Chem. Biochem.
, vol.271
, pp. 139-150
-
-
Alam, A.1
Rapthap, C.C.2
Singha, L.I.3
Sharan, R.N.4
Singh, V.5
-
31
-
-
0028200956
-
Clinical pharmacokinetic study and sensitive effect of AK-2123
-
Huan LC., Hua BY. (1994) Clinical pharmacokinetic study and sensitive effect of AK-2123. Int. J. Radiat. Oncol Biol Phys. 29: 607-610.
-
(1994)
Int. J. Radiat. Oncol Biol Phys.
, vol.29
, pp. 607-610
-
-
Huan, L.C.1
Hua, B.Y.2
-
32
-
-
0029870717
-
An overview of the initial experience with AK-2123 as a hypoxic cell sensitizer with radiation in the treatment of advanced head and neck cancers
-
Huilgol, N. G., Chatterjee, N. and Mehta, A. R. (1996) An overview of the initial experience with AK-2123 as a hypoxic cell sensitizer with radiation in the treatment of advanced head and neck cancers. Int. J. Radiat. Oncol. Biol. Phys. 34: 1121-1124.
-
(1996)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.34
, pp. 1121-1124
-
-
Huilgol, N.G.1
Chatterjee, N.2
Mehta, A.R.3
-
33
-
-
0023232996
-
Evaluation of various types of new hypoxic cell sensitizers using the EMT6 single cell - Spheroid - Solid tumor system
-
Shibamoto, Y., Nishimoto, S., Mi, F., Sasai, K., Kagiya, T. and Abe, M. (1987) Evaluation of various types of new hypoxic cell sensitizers using the EMT6 single cell - spheroid - solid tumor system. Int. J. Radiat. Biol. 52: 347-357.
-
(1987)
Int. J. Radiat. Biol.
, vol.52
, pp. 347-357
-
-
Shibamoto, Y.1
Nishimoto, S.2
Mi, F.3
Sasai, K.4
Kagiya, T.5
Abe, M.6
-
34
-
-
0016977447
-
Electron-affinic sensitization VII. A correlation between structures, one-electron reduction potentials and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers
-
Adams, G. E., Flockhart, I. R., Smithen, C. E., Stratford, I. J., Wardman, P., Watts, M. E. (1976) Electron-affinic sensitization VII. A correlation between structures, one-electron reduction potentials and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers. Radiat. Res. 67: 9-20.
-
(1976)
Radiat. Res.
, vol.67
, pp. 9-20
-
-
Adams, G.E.1
Flockhart, I.R.2
Smithen, C.E.3
Stratford, I.J.4
Wardman, P.5
Watts, M.E.6
-
35
-
-
4844229902
-
Stereotactic hypofractionated high-dose irradiation for stage i nonsmall cell lung carcinoma: Clinical outcomes in 245 subjects in a Japanese multiinstitutional study
-
Onishi, H., Araki, T., Shirato, H., Nagata, Y., Hiraoka, M., Gomi, K., Yamashita, T., Niibe, Y., Karasawa, K., Hayakawa, K., Takai, Y., Kimura, T., Hirokawa, Y., Takeda, A., Ouchi, A., Hareyama, M., Kokubo, M., Hara, R., Itami, J. and Yamada, K. (2004) Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer. 101: 1623-1631.
-
(2004)
Cancer
, vol.101
, pp. 1623-1631
-
-
Onishi, H.1
Araki, T.2
Shirato, H.3
Nagata, Y.4
Hiraoka, M.5
Gomi, K.6
Yamashita, T.7
Niibe, Y.8
Karasawa, K.9
Hayakawa, K.10
Takai, Y.11
Kimura, T.12
Hirokawa, Y.13
Takeda, A.14
Ouchi, A.15
Hareyama, M.16
Kokubo, M.17
Hara, R.18
Itami, J.19
Yamada, K.20
more..
|