Regulatory T cells and vasectomy

Journal of Reproductive Immunology

Volumn 100, Issue 1, 2013, Pages 66-75

  Rival, Claudia ^a   Wheeler, Karen ^a   Jeffrey, Sarah ^a   Qiao, Hui ^a   Luu, Brian ^a   Tewalt, Eric F ^b   Engelhard, Victor H ^b   Tardif, Stephen ^c   Hardy, Daniel ^c   del Rio, Roxana ^d   Teuscher, Cory ^d   Tung, Kenneth ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Autoimmune orchitis; Genetic control of autoimmunity; Post vasectomy sequel; Regulatory T cells; Sperm autoantibodies; Tolerance

Indexed keywords

CELL ANTIGEN; MEIOTIC GERM CELL ANTIGEN; SPERM ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; EPIDIDYMIS DISEASE; EPIDIDYMIS FIBROSIS; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE DEPLETION; MALE; MOUSE; NONHUMAN; ORCHITIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPERMATOGENESIS; T LYMPHOCYTE ACTIVATION; VASECTOMY;

AUTOIMMUNE ORCHITIS; GENETIC CONTROL OF AUTOIMMUNITY; POST-VASECTOMY SEQUEL; REGULATORY T CELLS; SPERM AUTOANTIBODIES; TOLERANCE;

ANIMALS; ANTIGENS, CD4; AUTOANTIBODIES; AUTOIMMUNITY; EPIDIDYMIS; FIBROSIS; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE DEPLETION; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORCHITIS; PROGRAMMED CELL DEATH 1 RECEPTOR; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; VASECTOMY;

EID: 84887018124     PISSN: 01650378     EISSN: 18727603     Source Type: Journal    
DOI: 10.1016/j.jri.2013.08.004     Document Type: Article

References (42)

1. Adams C.E., Wald M. Risks and complications of vasectomy. Urol. Clin. North Am. 2009, 36:331-336.
2. Alexander N.J., Anderson D.J. Vasectomy consequences of autoimmunity to sperm antigens. Fertil. Steril. 1979, 32:253-260.
3. Alexander N.J., Tung K.S.K. Immunological and morphological effects of vasectomy in the rabbit. Anat. Rec. 1977, 188:339-350.
4. Anderson D.J., Alexander N.J., Fulgham D.L., Palotay J.L. Spontaneous tumors in long-term-vasectomized mice. Increased incidence and association with antisperm immunity. Am. J. Pathol. 1983, 111:129-139.
5. Bigazzi P.E., Kosuda L.L., Hsu K.C., Andres G.A. Immune complex orchitis in vasectomized rabbits. J. Exp. Med. 1976, 143:382-404.
6. Bluestone J.A., Herold K., Eisenbarth G. Genetics pathogenesis and clinical interventions in type 1 diabetes. Nature 2010, 464:1293-1300.
7. Butterfield R.J., Sudweeks J.D., Blankenhorn E.P., Korngold R., Marini J.C., Todd J.A., Roper R.J., Teuscher C. New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. J. Immunol. 1998, 161:1860-1867.
8. del Rio R., Noubade R., Subramanian M., Saligrama N., Diehl S., Rincon M., Teuscher C. SNPs upstream of the minimal promoter control IL-2 expression and are candidates for the autoimmune disease-susceptibility locus Aod2/Idd3/Eae3. Genes Immunol. 2008, 9:115-121.
9. Fisson S., Darrasse-Jèze G., Litvinova E., Septier F., Klatzmann D., Liblau R., Salomon B.L. Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J. Exp. Med. 2003, 198:737-746.
10. Garza K.M., Agersborg S.S., Baker E., Tung K.S.K. Persistence of physiological self antigen is required for regulation of pathogenic autoimunity. J. Immunol. 2000, 164:3982-3989.
11. Horovitz D., Tjong V., Domes T., Lo K., Grober E., Jarvi D.K. Vasectomy reversal provides long-term relief for men with the post-vasectomy pain syndrome. J. Urol. 2012, 187:613-617.
12. Kaufman S.C., Alexander D.J. Vasectomy: autoimmunity and safety. Reproductive Immunology 1996, 629-639. Blackwell Science, Boston. R.A. Bronson, N.J. Alexander, D. Anderson, D.W. Branch, W.J. Kutteh (Eds.).
13. Kawai T., Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 2010, 11:373-384.
14. Köhler T.S., Fazili A.A., Brannigan R.E. Putative health risks associated with vasectomy. Urol. Clin. North Am. 2009, 36:337-345.
15. Kohno S., Munoz J.A., Williams T.M., Teuscher C., Bernard C.C.A., Tung K.S.K. Immunopathology of murine experimental allergic orchitis. J. Immunol. 1983, 130:2582-2675.
16. Kono H., Rock K.L. How dying cells alert the immune system to danger. Nat. Rev. Immunol. 2008, 8:279-289.
17. Lahl K., Loddenkemper C., Drouin C., Freyer J., Arnason J., Eberl G., Hamann A., Wagner H., Huehn J., Sparwasser T. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J. Exp. Med. 2007, 204:57-63.
18. Lathrop S.K., Santacruz N.A., Pham D., Luo J., Hsieh C.S. Antigen-specific peripheral shaping of the natural regulatory T cell population. J. Exp. Med. 2008, 205:3105-3117.
19. Lesko S.M., Louik C., Vezina R., Rosenberg L., Shapiro S. Vasectomy and prostate cancer. J. Urol. 1999, 161:1848-1852.
20. Maloy K.J., Salaun L., Cahill R., Dougan G., Saunders N.J., Powrie F. CD4+ CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 2003, 197:111-119.
21. Martinez F.O., Helming L., Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 2009, 27:451-483.
22. Matzinger P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 1994, 12:991-1045.
23. Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell 2010, 140:771-776.
24. Mettlin C., Natarajan N., Huben R. Vasectomy and prostate cancer risk. Am. J. Epidemiol. 1990, 132:1056-1061.
25. Riella L.V., Paterson A.M., Sharpe A.H., Chandraker A. Role of PD-1 pathway in the immune response. Am. J. Transplant. 2012, 12:2575-2587.
26. Rosenberg L., Palmer J.R., Zauber A.G., Warshauer M.E., Stolley P.D., Shapiro S. Vasectomy and the risk of prostate cancer. Am. J. Epidemiol. 1990, 132:1051-1055.
27. Samy E.T., Parker L.A., Sharp C.P., Tung K.S. Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+ CD25+ regulatory T cells in the regional lymph node. J. Exp. Med. 2005, 202:771-781.
28. + T cells in autoimmune disease suppression. Blood 2006, 107:62-1056.
29. Simpson A.J.G., Caballero O.L., Jungbluth A., Chen Y.T., Old L.J. Cancer/testis antigens, gametogenesis and cancer. Nat. Rev. Cancer 2005, 5:615-625.
30. Steinman R.M., Hawiger D., Nussenzweig M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 2003, 21:685-711.
31. Tardif S., Wilson M.D., Wagner R., Hunt P., Gertsenstein M., Nagy A., Lobe C., Koop B.F., Hardy D.M. Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida. J. Biol. Chem. 2010, 285:24863-24870.
32. Tung K.S.K. Allergic orchitis lesions are adoptively transferred from vasoligated guinea pigs to syngeneic recipients. Science 1978, 201:833-835.
33. Tung K.S.K., Menge A.C. Sperm and testicular autoimmunity. The Autoimmune Diseases 1985, 537-590. Academic, New York, NY. N.R. Rose, I.R. Mackay (Eds.).
34. Tung K.S., Setiady Y.Y., Samy E.T., Lewis J., Teuscher C. Autoimmune ovarian disease in day 3-thymectomized mice: the neonatal time window, antigen specificity of disease suppression, and genetic control. Curr. Top. Microbiol. Immunol. 2005, 293:209-247.
35. van Dingen J., Tekle F.B., van Roijen J.H. Pregnancy rate after vasectomy reversal in a contemporary series: influence of smoking, semen quality and post-surgical use of assisted reproductive techniques. BJU Int. 2012, 110:562-567.
36. Vesely M., Kershaw D., Schreiber M.H., Smyth R.D., M.J. Natural innate and adaptive immunity to cancer. Annu. Rev. Immunol. 2011, 29:71-235.
37. Walker L.S., Chodos A., Eggena M., Dooms H., Abbas A.K. Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J. Exp. Med. 2003, 198:249-258.
38. Watanabe H., Gehrke S., Contassot E., Roques S., Tschopp J., Friedmann P.S., French L.E., Gaide O. Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization. J. Immunol. 2008, 180:5826-5832.
39. Wheeler K.M., Samy E.T., Tung K.S.K. Cutting edge: normal regional lymph node enrichment of antigen-specific regulatory T cells with autoimmune disease-suppressive capacity. J. Immunol. 2009, 183:7635-7638.
40. Wheeler K.M., Tardif S., Rival C., Luu B., Bui E., Del Rio R., Sparwasser T., Teusher C., Hardy D.M., Tung K.S. Regulatory T cells control tolerance versus autoimmunity to sperm in vasectomy. Proc. Natl. Acad. Sci. 2011, 108:7511-7516.
41. Wing K., Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 2010, 11:7-13.
42. Yamanouchi J., et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet. 2007, 39:329-337.