-
1
-
-
78049267160
-
T regulatory cells and the control of alloimmunity: From characterisation to clinical application
-
Wieckiewicz, J., Goto, R., Wood, K. J. (2010) T regulatory cells and the control of alloimmunity: from characterisation to clinical application. Curr. Opin. Immunol. 22, 662-668.
-
(2010)
Curr. Opin. Immunol
, vol.22
, pp. 662-668
-
-
Wieckiewicz, J.1
Goto, R.2
Wood, K.J.3
-
2
-
-
65549127618
-
Human T regulatory cell therapy: Take a billion or so and call me in the morning
-
Riley, J. L., June, C. H., Blazar, B. R. (2009) Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity 30, 656-665.
-
(2009)
Immunity
, vol.30
, pp. 656-665
-
-
Riley, J.L.1
June, C.H.2
Blazar, B.R.3
-
3
-
-
47249124078
-
Human regulatory T cells: Role in autoimmune disease and therapeutic opportunities
-
Brusko, T. M., Putnam, A. L., Bluestone, J. A. (2008) Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol. Rev. 223, 371-390.
-
(2008)
Immunol. Rev
, vol.223
, pp. 371-390
-
-
Brusko, T.M.1
Putnam, A.L.2
Bluestone, J.A.3
-
4
-
-
70249122695
-
First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4 CD25 CD127 T regulatory cells
-
Trzonkowski, P., Bieniaszewska, M., Juscinska, J., Dobyszuk, A., Krzystyniak, A., Marek, N., Myskiwska, J., Hellmann, A. (2009) First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4 CD25 CD127 T regulatory cells. Clin. Immunol. 133, 22-26.
-
(2009)
Clin. Immunol
, vol.133
, pp. 22-26
-
-
Trzonkowski, P.1
Bieniaszewska, M.2
Juscinska, J.3
Dobyszuk, A.4
Krzystyniak, A.5
Marek, N.6
Myskiwska, J.7
Hellmann, A.8
-
5
-
-
78751696183
-
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
-
Brunstein, C. G., Miller, J. S., Cao, Q., McKenna, D. H., Hippen, K. L., Curtsinger, J., DeFor, T., Levine, B. L., June, C. H., Rubinstein, P., McGlave, P. B., Blazar, B. R., Wagner, J. E. (2011) Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 117, 1061-1070.
-
(2011)
Blood
, vol.117
, pp. 1061-1070
-
-
Brunstein, C.G.1
Miller, J.S.2
Cao, Q.3
McKenna, D.H.4
Hippen, K.L.5
Curtsinger, J.6
Defor, T.7
Levine, B.L.8
June, C.H.9
Rubinstein, P.10
McGlave, P.B.11
Blazar, B.R.12
Wagner, J.E.13
-
6
-
-
77955228203
-
Adoptive regulatory T cell therapy: Challenges in clinical transplantation
-
Safinia, N., Sagoo, P., Lechler, R., Lombardi, G. (2010) Adoptive regulatory T cell therapy: challenges in clinical transplantation. Curr. Opin. Organ Transplant. 15, 427-434.
-
(2010)
Curr. Opin. Organ Transplant
, vol.15
, pp. 427-434
-
-
Safinia, N.1
Sagoo, P.2
Lechler, R.3
Lombardi, G.4
-
7
-
-
4744356110
-
TGFinduces FoxP3 T-regulatory cells from CD4 CD25 precursors
-
Fu, S., Zhang, N., Yopp, A. C., Chen, D., Mao, M., Zhang, H., Ding, Y., Bromberg, J. S. (2004) TGFinduces FoxP3 T-regulatory cells from CD4 CD25 precursors. Am. J. Transplant. 4, 1614-1627.
-
(2004)
Am. J. Transplant
, vol.4
, pp. 1614-1627
-
-
Fu, S.1
Zhang, N.2
Yopp, A.C.3
Chen, D.4
Mao, M.5
Zhang, H.6
Ding, Y.7
Bromberg, J.S.8
-
8
-
-
0348223787
-
Conversion of peripheral CD4 CD25 naive T cells to CD4 CD25 regulatory T cells by TGFinduction of transcription factor FoxP3
-
Chen, W., Jin, W., Hardegen, N., Lei, K. J., Li, L., Marinos, N., McGrady, G., Wahl, S. M. (2003) Conversion of peripheral CD4 CD25 naive T cells to CD4 CD25 regulatory T cells by TGFinduction of transcription factor FoxP3. J. Exp. Med. 198, 1875-1886.
-
(2003)
J. Exp. Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
Lei, K.J.4
Li, L.5
Marinos, N.6
McGrady, G.7
Wahl, S.M.8
-
9
-
-
33846980131
-
Epigenetic control of the FoxP3 locus in regulatory T cells
-
Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J., Schlawe, K., Chang, H. D., Bopp, T., Schmitt, E., Klein-Hessling, S., Serfling, E., Hamann, A., Huehn, J. (2007) Epigenetic control of the FoxP3 locus in regulatory T cells. PLoS Biol. 5, e38.
-
(2007)
PLoS Biol
, vol.5
-
-
Floess, S.1
Freyer, J.2
Siewert, C.3
Baron, U.4
Olek, S.5
Polansky, J.6
Schlawe, K.7
Chang, H.D.8
Bopp, T.9
Schmitt, E.10
Klein-Hessling, S.11
Serfling, E.12
Hamann, A.13
Huehn, J.14
-
10
-
-
32244442562
-
TGFin the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., Stockinger, B. (2006) TGFin the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179-189.
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
11
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., Kuchroo, V. K. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
Weiner, H.L.7
Kuchroo, V.K.8
-
12
-
-
34447503805
-
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
-
Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., Cheroutre, H. (2007) Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256-260.
-
(2007)
Science
, vol.317
, pp. 256-260
-
-
Mucida, D.1
Park, Y.2
Kim, G.3
Turovskaya, O.4
Scott, I.5
Kronenberg, M.6
Cheroutre, H.7
-
13
-
-
78650723379
-
Characterization of protective human CD4 CD25 FOXP3 regulatory T cells generated with IL-2, TGFand retinoic acid
-
Lu, L., Zhou, X., Wang, J., Zheng, S. G., Horwitz, D. A. (2011) Characterization of protective human CD4 CD25 FOXP3 regulatory T cells generated with IL-2, TGFand retinoic acid. PLoS One 5, 1-12.
-
(2011)
PLoS One
, vol.5
, pp. 1-12
-
-
Lu, L.1
Zhou, X.2
Wang, J.3
Zheng, S.G.4
Horwitz, D.A.5
-
14
-
-
34547769253
-
Alltrans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
-
Benson, M. J., Pino-Lagos, K., Rosemblatt, M., Noelle, R. J. (2007) Alltrans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204, 1765-1774.
-
(2007)
J. Exp. Med
, vol.204
, pp. 1765-1774
-
-
Benson, M.J.1
Pino-Lagos, K.2
Rosemblatt, M.3
Noelle, R.J.4
-
15
-
-
79952389800
-
Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens
-
DePaolo, R. W., Abadie, V., Tang, F., Fehlner-Peach, H., Hall, J. A., Wang, W., Marietta, E. V., Kasarda, D. D., Waldmann, T. A., Murray, J. A., Semrad, C., Kupfer, S. S., Belkaid, Y., Guandalini, S., Jabri, B. (2011) Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 471, 220-224.
-
(2011)
Nature
, vol.471
, pp. 220-224
-
-
Depaolo, R.W.1
Abadie, V.2
Tang, F.3
Fehlner-Peach, H.4
Hall, J.A.5
Wang, W.6
Marietta, E.V.7
Kasarda, D.D.8
Waldmann, T.A.9
Murray, J.A.10
Semrad, C.11
Kupfer, S.S.12
Belkaid, Y.13
Guandalini, S.14
Jabri, B.15
-
16
-
-
0024541311
-
The role and mechanism of action of 13-cis-retinoic acid in the treatment of severe (nodulocystic) acne
-
Jones, D. H. (1989) The role and mechanism of action of 13-cis-retinoic acid in the treatment of severe (nodulocystic) acne. Pharmacol. Ther. 40, 91-106.
-
(1989)
Pharmacol. Ther
, vol.40
, pp. 91-106
-
-
Jones, D.H.1
-
17
-
-
0030067357
-
Percutaneous absorption, excretion and metabolism of all-trans-retinoyl beta-glucuronide and of all-transretinoic acid in the rat
-
Barua, A. B., Olson, J. A. (1996) Percutaneous absorption, excretion and metabolism of all-trans-retinoyl beta-glucuronide and of all-transretinoic acid in the rat. Skin Pharmacol. 9, 17-26.
-
(1996)
Skin Pharmacol
, vol.9
, pp. 17-26
-
-
Barua, A.B.1
Olson, J.A.2
-
18
-
-
35748956420
-
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3 T regulatory cells
-
Kopf, H., de la Rosa, G. M., Howard, O. M. Z., Chen, X. (2007) Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3 T regulatory cells. Int. Immunopharmacol. 7, 1819-1824.
-
(2007)
Int. Immunopharmacol
, vol.7
, pp. 1819-1824
-
-
Kopf, H.1
de la Rosa, G.M.2
Howard, O.M.Z.3
Chen, X.4
-
19
-
-
41149113441
-
The AKT-mTOR axis regulates de novo differentiation of CD4 FoxP3 cells
-
Haxhinasto, S., Mathis, D., Benoist, C. (2008) The AKT-mTOR axis regulates de novo differentiation of CD4 FoxP3 cells. J. Exp. Med. 205, 565-574.
-
(2008)
J. Exp. Med
, vol.205
, pp. 565-574
-
-
Haxhinasto, S.1
Mathis, D.2
Benoist, C.3
-
20
-
-
67749091321
-
Infectious tolerance via the consumption of essential amino acids and mTOR signaling
-
Cobbold, S. P., Adams, E., Farquhar, C. A., Nolan, K. F., Howie, D., Lui, K. O., Fairchild, P. J., Mellor, A. L., Ron, D., Waldmann, H. (2009) Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc. Natl. Acad. Sci. USA 106, 12055-12060.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 12055-12060
-
-
Cobbold, S.P.1
Adams, E.2
Farquhar, C.A.3
Nolan, K.F.4
Howie, D.5
Lui, K.O.6
Fairchild, P.J.7
Mellor, A.L.8
Ron, D.9
Waldmann, H.10
-
21
-
-
55549084247
-
Retinoic acid enhances FoxP3 induction indirectly by relieving inhibition from CD4 CD44hi cells
-
Hill, J. A., Hall, J. A., Sun, C. M., Cai, Q., Ghyselinck, N., Chambon, P., Belkaid, Y., Mathis, D., Benoist, C. (2008) Retinoic acid enhances FoxP3 induction indirectly by relieving inhibition from CD4 CD44hi cells. Immunity 29, 758-770.
-
(2008)
Immunity
, vol.29
, pp. 758-770
-
-
Hill, J.A.1
Hall, J.A.2
Sun, C.M.3
Cai, Q.4
Ghyselinck, N.5
Chambon, P.6
Belkaid, Y.7
Mathis, D.8
Benoist, C.9
-
22
-
-
22144479379
-
Oral tolerance in the absence of naturally occurring Tregs
-
Mucida, D., Kutchukhidze, N., Erazo, A., Russo, M., Lafaille, J. J., Curotto De Lafaille, M. A. (2005) Oral tolerance in the absence of naturally occurring Tregs. J. Clin. Invest. 115, 1923-1933.
-
(2005)
J. Clin. Invest
, vol.115
, pp. 1923-1933
-
-
Mucida, D.1
Kutchukhidze, N.2
Erazo, A.3
Russo, M.4
Lafaille, J.J.5
Curotto De Lafaille, M.A.6
-
23
-
-
33847337912
-
Tumor evasion of the immune system by converting CD4 CD25 T cells into CD4 CD25 T regulatory cells: Role of tumor-derived TGF-
-
Liu, V. C., Wong, L. Y., Jang, T., Shah, A. H., Park, I., Yang, X., Zhang, Q., Lonning, S., Teicher, B. A., Lee, C. (2007) Tumor evasion of the immune system by converting CD4 CD25 T cells into CD4 CD25 T regulatory cells: role of tumor-derived TGF-. J. Immunol. 178, 2883-2892.
-
(2007)
J. Immunol
, vol.178
, pp. 2883-2892
-
-
Liu, V.C.1
Wong, L.Y.2
Jang, T.3
Shah, A.H.4
Park, I.5
Yang, X.6
Zhang, Q.7
Lonning, S.8
Teicher, B.A.9
Lee, C.10
-
24
-
-
2442425262
-
Induction of foxP3 regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
-
Cobbold, S. P., Castejon, R., Adams, E., Zelenika, D., Graca, L., Humm, S., Waldmann, H. (2004) Induction of foxP3 regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J. Immunol. 172, 6003-6010.
-
(2004)
J. Immunol
, vol.172
, pp. 6003-6010
-
-
Cobbold, S.P.1
Castejon, R.2
Adams, E.3
Zelenika, D.4
Graca, L.5
Humm, S.6
Waldmann, H.7
-
25
-
-
79251500661
-
Phenotypical and functional specialization of FOXP3 regulatory T cells
-
Campbell, D. J., Koch, M. A. (2011) Phenotypical and functional specialization of FOXP3 regulatory T cells. Nat. Rev. Immunol. 11, 119-130.
-
(2011)
Nat. Rev. Immunol
, vol.11
, pp. 119-130
-
-
Campbell, D.J.1
Koch, M.A.2
-
26
-
-
34447643405
-
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor
-
Yamaguchi, T., Hirota, K., Nagahama, K., Ohkawa, K., Takahashi, T., Nomura, T., Sakaguchi, S. (2007) Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 27, 145-159.
-
(2007)
Immunity
, vol.27
, pp. 145-159
-
-
Yamaguchi, T.1
Hirota, K.2
Nagahama, K.3
Ohkawa, K.4
Takahashi, T.5
Nomura, T.6
Sakaguchi, S.7
-
27
-
-
65749119197
-
Hybrid Treg cells: Steel frames and plastic exteriors
-
Barnes, M. J., Powrie, F. (2009) Hybrid Treg cells: steel frames and plastic exteriors. Nat. Immunol. 10, 563-564.
-
(2009)
Nat. Immunol
, vol.10
, pp. 563-564
-
-
Barnes, M.J.1
Powrie, F.2
-
28
-
-
65749103365
-
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
-
Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., Campbell, D. J. (2009) The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595-602.
-
(2009)
Nat. Immunol
, vol.10
, pp. 595-602
-
-
Koch, M.A.1
Tucker-Heard, G.2
Perdue, N.R.3
Killebrew, J.R.4
Urdahl, K.B.5
Campbell, D.J.6
-
29
-
-
62649165369
-
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
-
Zheng, Y., Chaudhry, A., Kas, A., deRoos, P., Kim, J. M., Chu, T. T., Corcoran, L., reuting, P., Klein, U., Rudensky, A. Y. (2009) Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 458, 351-356.
-
(2009)
Nature
, vol.458
, pp. 351-356
-
-
Zheng, Y.1
Chaudhry, A.2
Kas, A.3
Deroos, P.4
Kim, J.M.5
Chu, T.T.6
Corcoran, L.7
Reuting, P.8
Klein, U.9
Rudensky, A.Y.10
-
30
-
-
77954948735
-
Effector T cell plasticity: Flexibility in the face of changing circumstances
-
Murphy, K. M., Stockinger, B. (2010) Effector T cell plasticity: flexibility in the face of changing circumstances. Nat. Immunol. 11, 674-680.
-
(2010)
Nat. Immunol
, vol.11
, pp. 674-680
-
-
Murphy, K.M.1
Stockinger, B.2
-
31
-
-
69049107358
-
Instability of the transcription factor FoxP3 leads to the generation of pathogenic memory T cells in vivo
-
Zhou, X., Bailey-Bucktrout, S. L., Jeker, L. T., Penaranda, C., Martinez Llordella, M., Ashby, M., Nakayama, M., Rosenthal, W., Bluestone, J. A. (2009) Instability of the transcription factor FoxP3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 10, 1000-1007.
-
(2009)
Nat. Immunol
, vol.10
, pp. 1000-1007
-
-
Zhou, X.1
Bailey-Bucktrout, S.L.2
Jeker, L.T.3
Penaranda, C.4
Martinez Llordella, M.5
Ashby, M.6
Nakayama, M.7
Rosenthal, W.8
Bluestone, J.A.9
-
32
-
-
67049097104
-
Developmental plasticity of Th17 and Treg cells
-
Lee, Y. K., Mukasa, R., Hatton, R. D., Weaver, C. T. (2009) Developmental plasticity of Th17 and Treg cells. Curr. Opin. Immunol. 21, 274-280.
-
(2009)
Curr. Opin. Immunol
, vol.21
, pp. 274-280
-
-
Lee, Y.K.1
Mukasa, R.2
Hatton, R.D.3
Weaver, C.T.4
-
33
-
-
58549112593
-
Delivery of rapamycin to dendritic cells using degradable microparticles
-
Jhunjhunwala, S., Raimondi, G., Thomson, A. W., Little, S. R. (2009) Delivery of rapamycin to dendritic cells using degradable microparticles. J. Control Rel. 133, 191-197.
-
(2009)
J. Control Rel
, vol.133
, pp. 191-197
-
-
Jhunjhunwala, S.1
Raimondi, G.2
Thomson, A.W.3
Little, S.R.4
-
34
-
-
0033523607
-
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
-
Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L., Powrie, F. (1999) An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190, 995-1004.
-
(1999)
J. Exp. Med
, vol.190
, pp. 995-1004
-
-
Asseman, C.1
Mauze, S.2
Leach, M.W.3
Coffman, R.L.4
Powrie, F.5
-
35
-
-
79959554060
-
Natural but not inducible regulatory T cells require TNF-÷ signaling for in vivo function
-
Housley, W. J., Adams, C. O., Nichols, F. C., Puddington, L., Lingenheld, E. G., Zhu, L., Rajan, T. V., Clark, R. B. (2011) Natural but not inducible regulatory T cells require TNF-÷ signaling for in vivo function. J. Immunol. 186, 6779-6787.
-
(2011)
J. Immunol
, vol.186
, pp. 6779-6787
-
-
Housley, W.J.1
Adams, C.O.2
Nichols, F.C.3
Puddington, L.4
Lingenheld, E.G.5
Zhu, L.6
Rajan, T.V.7
Clark, R.B.8
-
36
-
-
84871731716
-
Homing of regulatory T cells to human skin is important for the prevention of alloimmunemediated pathology in an in vivo cellular therapy model
-
Issa, F., Hester, J., Milward, K., Wood, K. J. (2012) Homing of regulatory T cells to human skin is important for the prevention of alloimmunemediated pathology in an in vivo cellular therapy model. PLoS One 7, e53331.
-
(2012)
PLoS One
, vol.7
-
-
Issa, F.1
Hester, J.2
Milward, K.3
Wood, K.J.4
-
37
-
-
84863011078
-
Induced FoxP3() regulatory T cells: A potential new weapon to treat autoimmune and inflammatory diseases
-
Lan, Q., Fan, H., Quesniaux, V., Ryffel, B., Liu, Z., Zheng, S. G. (2012) Induced FoxP3() regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases? J. Mol. Cell. Biol. 4, 22-28.
-
(2012)
J. Mol. Cell. Biol
, vol.4
, pp. 22-28
-
-
Lan, Q.1
Fan, H.2
Quesniaux, V.3
Ryffel, B.4
Liu, Z.5
Zheng, S.G.6
-
38
-
-
84859494040
-
Controlled release formulations of IL-2, TGF-1 and rapamycin for the induction of regulatory T cells
-
Jhunjhunwala, S., Balmert, S. C., Raimondi, G., Dons, E., Nichols, E. E., Thomson, A. W., Little, S. R. (2012) Controlled release formulations of IL-2, TGF-1 and rapamycin for the induction of regulatory T cells. J. Control Release 159, 78-84.
-
(2012)
J. Control Release
, vol.159
, pp. 78-84
-
-
Jhunjhunwala, S.1
Balmert, S.C.2
Raimondi, G.3
Dons, E.4
Nichols, E.E.5
Thomson, A.W.6
Little, S.R.7
|