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Volumn 4, Issue 9, 2012, Pages 919-938

Monoclonal antibody-based immunotherapy for multiple myeloma

Author keywords

humoral immunity; immunotherapy; molecular targets; monoclonal antibodies; multiple myeloma

Indexed keywords

BEVACIZUMAB; BHQ 880; BORTEZOMIB; BT 062; CANCER ANTIBODY; CD20 ANTIBODY; CD40 LIGAND MONOCLONAL ANTIBODY; CD74 ANTIGEN; DACETUZUMAB; DARATUMUMAB; DENOSUMAB; DEXAMETHASONE; ELOTUZUMAB; HULUC 63; IPH 2101; LENALIDOMIDE; LORVOTUZUMAB MERTANSINE; LUCATUMUMAB; MELPHALAN; MONOCLONAL ANTIBODY; NATALIZUMAB; P SELECTIN GLYCOPROTEIN LIGAND 1; PIDILIZUMAB; PLACEBO; PREDNISONE; RITUXIMAB; SILTUXIMAB; SYNDECAN 1; TOCILIZUMAB; TUMOR ANTIGEN; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

EID: 84867380709     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.12.82     Document Type: Review
Times cited : (6)

References (166)
  • 4
    • 77951614830 scopus 로고    scopus 로고
    • Monoclonal antibodies: Versatile platforms for cancer immunotherapy
    • Weiner LM, Surana R, Wang S. Monoclonal antibodies: versatile platforms for cancer immunotherapy. Nat. Rev. Immunol. 10(5), 317-327 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , Issue.5 , pp. 317-327
    • Weiner, L.M.1    Surana, R.2    Wang, S.3
  • 6
    • 77952128923 scopus 로고    scopus 로고
    • Humoral immunotherapy of multiple myeloma: Perspectives and perplexities
    • Di Bernardo A, Macor P, Guarnotta C et al. Humoral immunotherapy of multiple myeloma: perspectives and perplexities. Expert Opin Biol. Ther. 10(6), 863-873 (2010).
    • (2010) Expert Opin Biol. Ther. , vol.10 , Issue.6 , pp. 863-873
    • Di Bernardo, A.1    MacOr, P.2    Guarnotta, C.3
  • 14
    • 0037082449 scopus 로고    scopus 로고
    • CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells
    • DOI 10.1182/blood.V99.4.1419
    • Tai YT, Podar K, Gupta D et al. CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells. Blood 99(4), 1419-1427 (2002). (Pubitemid 34547100)
    • (2002) Blood , vol.99 , Issue.4 , pp. 1419-1427
    • Tai, Y.-T.1    Podar, K.2    Gupta, D.3    Lin, B.4    Young, G.5    Akiyama, M.6    Anderson, K.C.7
  • 20
    • 77958167235 scopus 로고    scopus 로고
    • Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies
    • Horton HM, Bernett MJ, Peipp M et al. Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies. Blood 116(16), 3004-3012 (2010).
    • (2010) Blood , vol.116 , Issue.16 , pp. 3004-3012
    • Horton, H.M.1    Bernett, M.J.2    Peipp, M.3
  • 22
    • 84875276871 scopus 로고    scopus 로고
    • Dacetuzumab (SGN-40), lenalidomide, and weekly dexamethasone in relapsed or refractory multiple myeloma: Multiple responses observed in a Phase 1b study
    • Presented at New Orleans, LA, USA, 5-8 December Abstract 2870
    • Agura E, Niesvizky R, Matous J et al. Dacetuzumab (SGN-40), lenalidomide, and weekly dexamethasone in relapsed or refractory multiple myeloma: multiple responses observed in a Phase 1b study. Presented at: 51st American Society of Hematology (ASH) Annual Meeting. New Orleans, LA, USA, 5-8 December 2009 (Abstract 2870).
    • (2009) 51st American Society of Hematology (ASH) Annual Meeting
    • Agura, E.1    Niesvizky, R.2    Matous, J.3
  • 23
    • 56449128746 scopus 로고    scopus 로고
    • New drugs in multiple myeloma: Mechanisms of action and Phase I/II clinical findings
    • Ocio EM, Mateos MV, Maiso P, Pandiella A, San-Miguel JF. New drugs in multiple myeloma: mechanisms of action and Phase I/II clinical findings. Lancet Oncol. 9(12), 1157-1165 (2008).
    • (2008) Lancet Oncol. , vol.9 , Issue.12 , pp. 1157-1165
    • Ocio, E.M.1    Mateos, M.V.2    Maiso, P.3    Pandiella, A.4    San-Miguel, J.F.5
  • 24
    • 51649083849 scopus 로고    scopus 로고
    • Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
    • Tai YT, Dillon M, Song W et al. Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. Blood 112(4), 1329-1337 (2008).
    • (2008) Blood , vol.112 , Issue.4 , pp. 1329-1337
    • Tai, Y.T.1    Dillon, M.2    Song, W.3
  • 25
    • 66149133630 scopus 로고    scopus 로고
    • CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells
    • Tai YT, Soydan E, Song W et al. CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells. Blood 113(18), 4309-4318 (2009).
    • (2009) Blood , vol.113 , Issue.18 , pp. 4309-4318
    • Tai, Y.T.1    Soydan, E.2    Song, W.3
  • 26
    • 52049104695 scopus 로고    scopus 로고
    • CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma
    • Hsi ED, Steinle R, Balasa B et al. CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma. Clin. Cancer Res. 14(9), 2775-2784 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.9 , pp. 2775-2784
    • Hsi, E.D.1    Steinle, R.2    Balasa, B.3
  • 27
    • 84875265821 scopus 로고    scopus 로고
    • Eradication of tumors in pre-clinical models of multiple myeloma by anti-CS1 monoclonal antibody HuLuc63: Mechanism of action studies
    • Presented at Orlando, FL, USA 9-11 December Abstract 3503
    • Rice A, Dylan M, Van Abbema A et al. Eradication of tumors in pre-clinical models of multiple myeloma by anti-CS1 monoclonal antibody HuLuc63: mechanism of action studies. Presented at: 48th American Society of Hematology (ASH) Annual Meeting. Orlando, FL, USA, 9-11 December 2006 (Abstract 3503).
    • (2006) 48th American Society of Hematology (ASH) Annual Meeting
    • Rice, A.1    Dylan, M.2    Van Abbema, A.3
  • 29
    • 69249194808 scopus 로고    scopus 로고
    • Phase i study of elotuzumab (HuLuc63) in relapsed/refractory multiple myeloma
    • Abstract 2773
    • Zonder JA, Singhal S, Bensinger W et al. Phase I study of elotuzumab (HuLuc63) in relapsed/refractory multiple myeloma. Blood (ASH Annual Meeting Abstracts) 112(11), Abstract 2773 (2008).
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , Issue.11
    • Zonder, J.A.1    Singhal, S.2    Bensinger, W.3
  • 30
    • 79961080839 scopus 로고    scopus 로고
    • Elotuzumab in combination with bortezomib in patients with relapsed/refractory multiple myeloma: Updated results of a Phase 1 study
    • Abstract 3023
    • Jakubowiak AJ, Benson DM Jr, Bensinger W et al. Elotuzumab in combination with bortezomib in patients with relapsed/refractory multiple myeloma: updated results of a Phase 1 study. Blood (ASH Annual Meeting Abstracts) 116(21), Abstract 3023 (2010).
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , Issue.21
    • Jakubowiak, A.J.1    Benson Jr., D.M.2    Bensinger, W.3
  • 31
    • 79961096460 scopus 로고    scopus 로고
    • Elotuzumab in combination with lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma: Results of a Phase 1 study
    • Abstract 1936
    • Lonial S, Vij R, Harousseau J-L et al. Elotuzumab in combination with lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma: results of a Phase 1 study. Blood (ASH Annual Meeting Abstracts) 116(21), Abstract 1936 (2010).
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , Issue.21
    • Lonial, S.1    Vij, R.2    Harousseau, J.-L.3
  • 32
    • 79955732984 scopus 로고    scopus 로고
    • Elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma: Interim results of a Phase 2 study
    • Abstract 986
    • Richardson PG, Moreau P, Jakubowiak AJ et al. Elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma: interim results of a Phase 2 study. Blood (ASH Annual Meeting Abstracts) 116(21), Abstract 986 (2010).
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , Issue.21
    • Richardson, P.G.1    Moreau, P.2    Jakubowiak, A.J.3
  • 34
    • 0030722012 scopus 로고    scopus 로고
    • Elevated levels of shed syndecan-1 correlate with tumour mass and decreased matrix metalloproteinase-9 activity in the serum of patients with multiple myeloma
    • Dhodapkar MV, Kelly T, Theus A, Athota AB, Barlogie B, Sanderson RD. Elevated levels of shed syndecan-1 correlate with tumour mass and decreased matrix metalloproteinase-9 activity in the serum of patients with multiple myeloma. Br. J. Haematol. 99(2), 368-371 (1997). (Pubitemid 27497569)
    • (1997) British Journal of Haematology , vol.99 , Issue.2 , pp. 368-371
    • Dhodapkar, M.V.1    Kelly, T.2    Theus, A.3    Athota, A.B.4    Barlogie, B.5    Sanderson, R.D.6
  • 35
    • 0034780729 scopus 로고    scopus 로고
    • Syndecan-1 (CD138) immunoreactivity in bone marrow biopsies of multiple myeloma: Shed syndecan-1 accumulates in fibrotic regions
    • DOI 10.1038/modpathol.3880435
    • Bayer-Garner IB, Sanderson RD, Dhodapkar MV, Owens RB, Wilson CS. Syndecan-1 (CD138) immunoreactivity in bone marrow biopsies of multiple myeloma: shed syndecan-1 accumulates in fibrotic regions. Mod. Pathol. 14(10), 1052-1058 (2001). (Pubitemid 32976795)
    • (2001) Modern Pathology , vol.14 , Issue.10 , pp. 1052-1058
    • Bayer-Garner, I.B.1    Sanderson, R.D.2    Dhodapkar, M.V.3    Owens, R.B.4    Wilson, C.S.5
  • 38
    • 0032859718 scopus 로고    scopus 로고
    • Efficacy of an anti-CD138 immunotoxin and doxorubicin on drug-resistant and drug-sensitive myeloma cells
    • DOI 10.1002/(SICI)1097-0215(19991112)83:4<571::AID-IJC21>3.0.CO;2-N
    • Post J, Vooijs WC, Bast BJ, De Gast GC. Efficacy of an anti-CD138 immunotoxin and doxorubicin on drug-resistant and drug-sensitive myeloma cells. Int. J. Cancer 83(4), 571-576 (1999). (Pubitemid 29489875)
    • (1999) International Journal of Cancer , vol.83 , Issue.4 , pp. 571-576
    • Post, J.1    Vooijs, W.C.2    Bast, B.J.E.G.3    De Gast, G.C.4
  • 41
    • 0037033448 scopus 로고    scopus 로고
    • Antitumor monoclonal antibodies enhance cross-presentation of cellular antigens and the generation of myeloma-specific killer T cells by dendritic cells
    • DOI 10.1084/jem.20011097
    • Dhodapkar KM, Krasovsky J, Williamson B, Dhodapkar MV. Antitumor monoclonal antibodies enhance cross-presentation of cellular antigens and the generation of myeloma-specific killer T cells by dendritic cells. J. Exp. Med. 195(1), 125-133 (2002). (Pubitemid 34074502)
    • (2002) Journal of Experimental Medicine , vol.195 , Issue.1 , pp. 125-133
    • Dhodapkar, K.M.1    Krasovsky, J.2    Williamson, B.3    Dhodapkar, M.V.4
  • 43
    • 5144224056 scopus 로고    scopus 로고
    • Antiproliferative activity of a humanized anti-CD74 monoclonal antibody, hLL1, on B-cell malignancies
    • DOI 10.1182/blood-2004-03-0890
    • Stein R, Qu Z, Cardillo TM et al. Antiproliferative activity of a humanized anti-CD74 monoclonal antibody, hLL1, on B-cell malignancies. Blood 104(12), 3705-3711 (2004). (Pubitemid 39564448)
    • (2004) Blood , vol.104 , Issue.12 , pp. 3705-3711
    • Stein, R.1    Qu, Z.2    Cardillo, T.M.3    Chen, S.4    Rosario, A.5    Horak, I.D.6    Hansen, H.J.7    Goldenberg, D.M.8
  • 45
    • 22944479671 scopus 로고    scopus 로고
    • Identification of CD162 in plasma-cell dyscrasia
    • DOI 10.1016/S1470-2045(05)70287-4, PII S1470204505702874
    • Florena AM, Tripodo C, Miceli L, Ingrao S, Porcasi R, Franco V. Identification of CD162 in plasma-cell dyscrasia. Lancet Oncol. 6(8), 632 (2005). (Pubitemid 41051943)
    • (2005) Lancet Oncology , vol.6 , Issue.8 , pp. 632
    • Florena, A.M.1    Tripodo, C.2    Miceli, L.3    Ingrao, S.4    Porcasi, R.5    Franco, V.6
  • 46
    • 69249231029 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand-1 as a potential target for humoral immunotherapy of multiple myeloma
    • Tripodo C, Florena AM, Macor P et al. P-selectin glycoprotein ligand-1 as a potential target for humoral immunotherapy of multiple myeloma. Curr. Cancer Drug Targets 9(5), 617-625 (2009).
    • (2009) Curr. Cancer Drug Targets. , vol.9 , Issue.5 , pp. 617-625
    • Tripodo, C.1    Florena, A.M.2    MacOr, P.3
  • 48
    • 41249095663 scopus 로고    scopus 로고
    • Radioimmunotherapy-Based Conditioning Regimens for Stem Cell Transplantation
    • DOI 10.1053/j.seminhematol.2008.02.002, PII S0037196308000036
    • Zhang MM, Gopal AK. Radioimmunotherapy-based conditioning regimens for stem cell transplantation. Semin. Hematol. 45(2), 118-125 (2008). (Pubitemid 351444840)
    • (2008) Seminars in Hematology , vol.45 , Issue.2 , pp. 118-125
    • Zhang, M.M.1    Gopal, A.K.2
  • 49
    • 77952619392 scopus 로고    scopus 로고
    • CD66a (CEACAM1) is the only CD66 variant expressed on the surface of plasma cells in multiple myeloma: A refined target for radiotherapy trials? Br
    • Lee C, Guinn BA, Brooks SE, Richardson D, Orchard K. CD66a (CEACAM1) is the only CD66 variant expressed on the surface of plasma cells in multiple myeloma: a refined target for radiotherapy trials? Br. J. Haematol. 149(5), 795-796 (2010).
    • (2010) J. Haematol. , vol.149 , Issue.5 , pp. 795-796
    • Lee, C.1    Guinn, B.A.2    Brooks, S.E.3    Richardson, D.4    Orchard, K.5
  • 50
    • 0028584445 scopus 로고
    • Structures of two classes of MHC molecules elucidated: Crucial differences and similarities
    • Bjorkman PJ, Burmeister WP. Structures of two classes of MHC molecules elucidated: crucial differences and similarities. Curr. Opin Struct. Biol. 4(6), 852-856 (1994).
    • (1994) Curr. Opin Struct. Biol. , vol.4 , Issue.6 , pp. 852-856
    • Bjorkman, P.J.1    Burmeister, W.P.2
  • 51
    • 0019251465 scopus 로고
    • Beta-2-microglobulin review: Its relevance in clinical oncology
    • DOI 10.1002/mpo.2950080403
    • Cooper EH, Plesner T. Beta-2-microglobulin review: its relevance in clinical oncology. Med. Pediatr. Oncol. 8(4), 323-334 (1980). (Pubitemid 11138381)
    • (1980) Medical and Pediatric Oncology , vol.8 , Issue.4 , pp. 323-334
    • Cooper, E.H.1    Plesner, T.2
  • 54
    • 35548986278 scopus 로고    scopus 로고
    • 2-microglobulin monoclonal antibodies induce apoptosis in myeloma cells by recruiting MHC class I to and excluding growth and survival cytokine receptors from lipid rafts
    • DOI 10.1182/blood-2007-06-094417
    • Yang J, Zhang X, Wang J et al. Anti beta2-microglobulin monoclonal antibodies induce apoptosis in myeloma cells by recruiting MHC class I to and excluding growth and survival cytokine receptors from lipid rafts. Blood 110(8), 3028-3035 (2007). (Pubitemid 350006957)
    • (2007) Blood , vol.110 , Issue.8 , pp. 3028-3035
    • Yang, J.1    Zhang, X.2    Wang, J.3    Qian, J.4    Zhang, L.5    Wang, M.6    Kwak, L.W.7    Yi, Q.8
  • 55
    • 33847057383 scopus 로고    scopus 로고
    • A single-chain Fv diabody against human leukocyte antigen-A molecules specifically induces myeloma cell death in the bone marrow environment
    • Sekimoto E, Ozaki S, Ohshima T et al. A single-chain Fv diabody against human leukocyte antigen-A molecules specifically induces myeloma cell death in the bone marrow environment. Cancer Res. 67(3), 1184-1192 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.3 , pp. 1184-1192
    • Sekimoto, E.1    Ozaki, S.2    Ohshima, T.3
  • 56
    • 79958829840 scopus 로고    scopus 로고
    • Targeting cell surface beta2-microglobulin by pentameric IgM antibodies
    • Cao Y, Lan Y, Qian J et al. Targeting cell surface beta2-microglobulin by pentameric IgM antibodies. Br. J. Haematol. 154(1), 111-121 (2011).
    • (2011) Br. J. Haematol. , vol.154 , Issue.1 , pp. 111-121
    • Cao, Y.1    Lan, Y.2    Qian, J.3
  • 57
    • 0028908877 scopus 로고
    • In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain
    • Bergsagel PL, Smith AM, Szczepek A, Mant MJ, Belch AR, Pilarski LM. In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain. Blood 85(2), 436-447 (1995).
    • (1995) Blood , vol.85 , Issue.2 , pp. 436-447
    • Bergsagel, P.L.1    Smith, A.M.2    Szczepek, A.3    Mant, M.J.4    Belch, A.R.5    Pilarski, L.M.6
  • 58
    • 0028930578 scopus 로고
    • Evaluation of CD38 as target for immunotherapy in multiple myeloma
    • Vooijs WC, Schuurman HJ, Bast EJ, De Gast GC. Evaluation of CD38 as target for immunotherapy in multiple myeloma. Blood 85(8), 2282-2284 (1995).
    • (1995) Blood , vol.85 , Issue.8 , pp. 2282-2284
    • Vooijs, W.C.1    Schuurman, H.J.2    Bast, E.J.3    De Gast, G.C.4
  • 59
    • 0035177850 scopus 로고    scopus 로고
    • Human CD38: A (r)evolutionary story of enzymes and receptors
    • DOI 10.1016/S0145-2126(00)00093-X, PII S014521260000093X
    • Deaglio S, Mehta K, Malavasi F. Human CD38: a (r)evolutionary story of enzymes and receptors. Leuk. Res. 25(1), 1-12 (2001). (Pubitemid 32012975)
    • (2001) Leukemia Research , vol.25 , Issue.1 , pp. 1-12
    • Deaglio, S.1    Mehta, K.2    Malavasi, F.3
  • 60
    • 0025980998 scopus 로고
    • Preliminary studies for an immunotherapeutic approach to the treatment of human myeloma using chimeric anti-CD38 antibody
    • Stevenson FK, Bell AJ, Cusack R et al. Preliminary studies for an immunotherapeutic approach to the treatment of human myeloma using chimeric anti-CD38 antibody. Blood 77(5), 1071-1079 (1991).
    • (1991) Blood , vol.77 , Issue.5 , pp. 1071-1079
    • Stevenson, F.K.1    Bell, A.J.2    Cusack, R.3
  • 61
    • 0029030308 scopus 로고
    • Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma
    • Ellis JH, Barber KA, Tutt A et al. Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma. J. Immunol. 155(2), 925-937 (1995).
    • (1995) J. Immunol. , vol.155 , Issue.2 , pp. 925-937
    • Ellis, J.H.1    Barber, K.A.2    Tutt, A.3
  • 62
    • 1642348370 scopus 로고    scopus 로고
    • Flow Cytometric Immunophenotypic Analysis of 306 Cases of Multiple Myeloma
    • DOI 10.1309/74R4-TB90-BUWH-27JX
    • Lin P, Owens R, Tricot G, Wilson CS. Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma. Am. J. Clin. Pathol. 121(4), 482-488 (2004). (Pubitemid 38392955)
    • (2004) American Journal of Clinical Pathology , vol.121 , Issue.4 , pp. 482-488
    • Lin, P.1    Owens, R.2    Tricot, G.3    Wilson, C.S.4
  • 63
    • 33947633987 scopus 로고    scopus 로고
    • CD38 as a therapeutic target
    • DOI 10.2119/2006-00082.Stevenson
    • Stevenson GT. CD38 as a therapeutic target. Mol. Med. 12(11-12), 345-346 (2006). (Pubitemid 46489831)
    • (2006) Molecular Medicine , vol.12 , Issue.11-12 , pp. 345-346
    • Stevenson, G.T.1
  • 64
    • 79251570884 scopus 로고    scopus 로고
    • Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors
    • De Weers M, Tai YT, Van Der Veer MS et al. Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors. J. Immunol. 186(3), 1840-1848 (2011).
    • (2011) J. Immunol. , vol.186 , Issue.3 , pp. 1840-1848
    • De Weers, M.1    Tai, Y.T.2    Van Der Veer, M.S.3
  • 65
    • 84875241285 scopus 로고    scopus 로고
    • A Phase I/II, dose-escalation study of daratumumab, a CD38 mAb in patients with multiple myeloma-preliminary safety data
    • Presented at San Diego, CA, USA 10-13 December 2011 Abstract, 1873
    • Gimsing P, Plesner T, Nahi H et al. A Phase I/II, dose-escalation study of daratumumab, a CD38 mAb in patients with multiple myeloma-preliminary safety data. Presented at: ASH Annual Meeting. San Diego, CA, USA, 10-13 December 2011 (Abstract 1873).
    • ASH Annual Meeting
    • Gimsing, P.1    Plesner, T.2    Nahi, H.3
  • 66
    • 84887961227 scopus 로고    scopus 로고
    • Daratumumab, a CD38 mAb, for the treatment of relapsed/refractory multiple myeloma patients: Preliminary efficacy data from a multicenter Phase I/II study
    • Presented at Chicago, IL, USA 1-5 June 2012 (Abstract 8019
    • Plesner T, Lokhorst H, Gimsing P, Nahi H, Lisby S, Richardson P. Daratumumab, a CD38 mAb, for the treatment of relapsed/refractory multiple myeloma patients: preliminary efficacy data from a multicenter Phase I/II study. Presented at: ASCO Annual Meeting. Chicago, IL, USA, 1-5 June 2012 (Abstract 8019).
    • ASCO Annual Meeting
    • Plesner, T.1    Lokhorst, H.2    Gimsing, P.3    Nahi, H.4    Lisby, S.5    Richardson, P.6
  • 67
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: Clinical applications
    • DOI 10.1182/blood-2004-01-0037
    • Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC. Advances in biology of multiple myeloma: clinical applications. Blood 104(3), 607-618 (2004). (Pubitemid 38970551)
    • (2004) Blood , vol.104 , Issue.3 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3    Anderson, K.C.4
  • 68
    • 79251581902 scopus 로고    scopus 로고
    • Towards effective immunotherapy of myeloma: Enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab
    • Van der Veer MS, de Weers M, van Kessel B et al. Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab. Haematologica 96(2), 284-290 (2011).
    • (2011) Haematologica. , vol.96 , Issue.2 , pp. 284-290
    • Van Der Veer, M.S.1    De Weers, M.2    Van Kessel, B.3
  • 69
    • 84875245066 scopus 로고    scopus 로고
    • The potential of the human CD38-specific antibody daratumumab to improve the antimyeloma effect of novel multidrug therapies including patients refractory to lenalidomide or bortezomib
    • Mutis T, de Weers M, van der Veer MS et al. The potential of the human CD38-specific antibody daratumumab to improve the antimyeloma effect of novel multidrug therapies including patients refractory to lenalidomide or bortezomib. J. Clin. Oncol. 29(15 Suppl.), e18571 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.15 SUPPL.
    • Mutis, T.1    De Weers, M.2    Van Der Veer, M.S.3
  • 70
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl Acad. Sci. USA 99(19), 12293-12297 (2002).
    • (2002) Proc. Natl Acad. Sci. USA. , vol.99 , Issue.19 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 72
    • 49649114804 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • Berger R, Rotem-Yehudar R, Slama G et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin. Cancer Res. 14(10), 3044-3051 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.10 , pp. 3044-3051
    • Berger, R.1    Rotem-Yehudar, R.2    Slama, G.3
  • 73
    • 77957701558 scopus 로고    scopus 로고
    • The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: A therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
    • Benson DM Jr, Bakan CE, Mishra A et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood 116(13), 2286-2294 (2010).
    • (2010) Blood , vol.116 , Issue.13 , pp. 2286-2294
    • Benson Jr., D.M.1    Bakan, C.E.2    Mishra, A.3
  • 74
    • 0142250392 scopus 로고    scopus 로고
    • Targeted Anti-Interleukin-6 Monoclonal Antibody Therapy for Cancer: A Review of the Rationale and Clinical Evidence
    • Trikha M, Corringham R, Klein B, Rossi JF. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin. Cancer Res. 9(13), 4653-4665 (2003). (Pubitemid 37323267)
    • (2003) Clinical Cancer Research , vol.9 , Issue.13 , pp. 4653-4665
    • Trikha, M.1    Corringham, R.2    Klein, B.3    Rossi, J.-F.4
  • 75
    • 70450287394 scopus 로고    scopus 로고
    • Preliminary results of CNTO 328, an anti-interleukin-6 monoclonal antibody, in combination with bortezomib in the treatment of relapsed or refractory multiple myeloma
    • Abstract 867
    • Rossi JF, Manges RF, Sutherland HJ et al. Preliminary results of CNTO 328, an anti-interleukin-6 monoclonal antibody, in combination with bortezomib in the treatment of relapsed or refractory multiple myeloma. Blood (ASH Annual Meeting Abstracts) 112(11), Abstract 867 (2008).
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , Issue.11
    • Rossi, J.F.1    Manges, R.F.2    Sutherland, H.J.3
  • 76
    • 84875243259 scopus 로고    scopus 로고
    • Phase II, randomized, double blind, placebo-controlled study comparing siltuximab plus bortezomib versus bortezomib alone in pts with relapsed/refractory multiple myeloma
    • Abstract 8018
    • Orlowski RZ, Gercheva L, Williams C et al. Phase II, randomized, double blind, placebo-controlled study comparing siltuximab plus bortezomib versus bortezomib alone in pts with relapsed/refractory multiple myeloma. J. Clin. Oncol. 30(15 Suppl.), Abstract 8018 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.15 SUPPL.
    • Orlowski, R.Z.1    Gercheva, L.2    Williams, C.3
  • 77
    • 84862645333 scopus 로고    scopus 로고
    • A Phase 2 multicenter study of siltuximab, an anti-IL-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma
    • Abstract 3971
    • Voorhees PM, Sonneveld P, Jagannath S et al. A Phase 2 multicenter study of siltuximab, an anti-IL-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma. Blood (ASH Annual Meeting Abstracts) 118(21), Abstract 3971 (2011).
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21
    • Voorhees, P.M.1    Sonneveld, P.2    Jagannath, S.3
  • 78
    • 0034046108 scopus 로고    scopus 로고
    • A combination of anti-interleukin 6 murine monoclonal antibody with dexamethasone and high-dose melphalan induces high complete response rates in advanced multiple myeloma
    • DOI 10.1046/j.1365-2141.2000.02093.x
    • Moreau P, Harousseau JL, Wijdenes J, Morineau N, Milpied N, Bataille R. A combination of anti-interleukin 6 murine monoclonal antibody with dexamethasone and high-dose melphalan induces high complete response rates in advanced multiple myeloma. Br. J. Haematol. 109(3), 661-664 (2000). (Pubitemid 30415199)
    • (2000) British Journal of Haematology , vol.109 , Issue.3 , pp. 661-664
    • Moreau, P.1    Harousseau, J.-L.2    Wijdenes, J.3    Morineau, N.4    Milpied, N.5    Bataille, R.6
  • 81
    • 79951556761 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma
    • Hunsucker SA, Magarotto V, Kuhn DJ et al. Blockade of interleukin-6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma. Br. J. Haematol. 152(5), 579-592 (2011).
    • (2011) Br. J. Haematol. , vol.152 , Issue.5 , pp. 579-592
    • Hunsucker, S.A.1    Magarotto, V.2    Kuhn, D.J.3
  • 82
    • 33847084044 scopus 로고    scopus 로고
    • Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor
    • Yoshio-Hoshino N, Adachi Y, Aoki C, Pereboev A, Curiel DT, Nishimoto N. Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor. Cancer Res. 67(3), 871-875 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.3 , pp. 871-875
    • Yoshio-Hoshino, N.1    Adachi, Y.2    Aoki, C.3    Pereboev, A.4    Curiel, D.T.5    Nishimoto, N.6
  • 83
    • 73149112786 scopus 로고    scopus 로고
    • A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma
    • Fulciniti M, Hideshima T, Vermot-Desroches C et al. A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma. Clin. Cancer Res. 15(23), 7144-7152 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.23 , pp. 7144-7152
    • Fulciniti, M.1    Hideshima, T.2    Vermot-Desroches, C.3
  • 84
    • 76649086587 scopus 로고    scopus 로고
    • A humanized anti-ganglioside GM2 antibody, BIW-8962, exhibits ADCC/CDC activity against multiple myeloma cells and potent anti-tumor activity in mouse xenograft models
    • Abstract 1718
    • Ishii T, Chanan-Khan A, Jafferjee J et al. A humanized anti-ganglioside GM2 antibody, BIW-8962, exhibits ADCC/CDC activity against multiple myeloma cells and potent anti-tumor activity in mouse xenograft models. Blood (ASH Annual Meeting Abstracts) 112(11), Abstract 1718 (2008).
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , Issue.11
    • Ishii, T.1    Chanan-Khan, A.2    Jafferjee, J.3
  • 86
    • 79251631976 scopus 로고    scopus 로고
    • Structure/function of human killer cell immunoglobulin-like receptors: Lessons from polymorphisms, evolution, crystal structures and mutations
    • Campbell KS, Purdy AK. Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations. Immunology 132(3), 315-325 (2011).
    • (2011) Immunology. , vol.132 , Issue.3 , pp. 315-325
    • Campbell, K.S.1    Purdy, A.K.2
  • 87
    • 83455220035 scopus 로고    scopus 로고
    • IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
    • Benson DM Jr, Bakan CE, Zhang S et al. IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect. Blood 118(24), 6387-6391 (2011).
    • (2011) Blood , vol.118 , Issue.24 , pp. 6387-6391
    • Benson Jr., D.M.1    Bakan, C.E.2    Zhang, S.3
  • 88
    • 0028101333 scopus 로고
    • A novel membrane antigen selectively expressed on terminally differentiated human B cells
    • Goto T, Kennel SJ, Abe M et al. A novel membrane antigen selectively expressed on terminally differentiated human B cells. Blood 84(6), 1922-1930 (1994). (Pubitemid 24286144)
    • (1994) Blood , vol.84 , Issue.6 , pp. 1922-1930
    • Goto, T.1    Kennel, S.J.2    Abe, M.3    Takishita, M.4    Kosaka, M.5    Solomon, A.6    Saito, S.7
  • 90
    • 84863251086 scopus 로고    scopus 로고
    • Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function
    • Tai YT, Horton HM, Kong SY et al. Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function. Blood 119(9), 2074-2082 (2012).
    • (2012) Blood , vol.119 , Issue.9 , pp. 2074-2082
    • Tai, Y.T.1    Horton, H.M.2    Kong, S.Y.3
  • 91
    • 33645218704 scopus 로고    scopus 로고
    • Engineered antibody Fc variants with enhanced effector function
    • Lazar GA, Dang W, Karki S et al. Engineered antibody Fc variants with enhanced effector function. Proc. Natl Acad. Sci. USA 103(11), 4005-4010 (2006).
    • (2006) Proc. Natl Acad. Sci. USA. , vol.103 , Issue.11 , pp. 4005-4010
    • Lazar, G.A.1    Dang, W.2    Karki, S.3
  • 92
    • 54249100952 scopus 로고    scopus 로고
    • Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia
    • Horton HM, Bernett MJ, Pong E et al. Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia. Cancer Res. 68(19), 8049-8057 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.19 , pp. 8049-8057
    • Horton, H.M.1    Bernett, M.J.2    Pong, E.3
  • 93
    • 24344507278 scopus 로고    scopus 로고
    • Drug-conjugated monoclonal antibodies for the treatment of cancer
    • DOI 10.1016/j.coph.2005.04.017, PII S1471489205001177
    • Lambert JM. Drug-conjugated monoclonal antibodies for the treatment of cancer. Curr. Opin Pharmacol. 5(5), 543-549 (2005). (Pubitemid 41258574)
    • (2005) Current Opinion in Pharmacology , vol.5 , Issue.5 , pp. 543-549
    • Lambert, J.M.1
  • 94
    • 67649886201 scopus 로고    scopus 로고
    • Potent antibody drug conjugates for cancer therapy
    • Senter PD. Potent antibody drug conjugates for cancer therapy. Curr. Opin Chem. Biol. 13(3), 235-244 (2009).
    • (2009) Curr. Opin Chem. Biol. , vol.13 , Issue.3 , pp. 235-244
    • Senter, P.D.1
  • 95
    • 38949192547 scopus 로고    scopus 로고
    • Targeted cancer therapy: Conferring specificity to cytotoxic drugs
    • Chari RV. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc. Chem. Res. 41(1), 98-107 (2008).
    • (2008) Acc. Chem. Res. , vol.41 , Issue.1 , pp. 98-107
    • Chari, R.V.1
  • 96
    • 77953663858 scopus 로고    scopus 로고
    • Antibody-maytansinoid conjugates for the treatment of myeloma
    • Lutz RJ, Whiteman KR. Antibody-maytansinoid conjugates for the treatment of myeloma. MAbs 1(6), 548-551 (2009).
    • (2009) MAbs. , vol.1 , Issue.6 , pp. 548-551
    • Lutz, R.J.1    Whiteman, K.R.2
  • 97
    • 33645500289 scopus 로고    scopus 로고
    • Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
    • Erickson HK, Park PU, Widdison WC et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res. 66(8), 4426-4433 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.8 , pp. 4426-4433
    • Erickson, H.K.1    Park, P.U.2    Widdison, W.C.3
  • 98
    • 0020529372 scopus 로고
    • Characterization of an antigen expressed by human natural killer cells
    • Griffin JD, Hercend T, Beveridge R, Schlossman SF. Characterization of an antigen expressed by human natural killer cells. J. Immunol. 130(6), 2947-2951 (1983). (Pubitemid 13107737)
    • (1983) Journal of Immunology , vol.130 , Issue.6 , pp. 2947-2951
    • Griffin, J.D.1    Hercend, T.2    Beveridge, R.3    Schlossman, S.F.4
  • 99
    • 0022589079 scopus 로고
    • The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes
    • Lanier LL, Le AM, Civin CI, Loken MR, Phillips JH. The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J. Immunol. 136(12), 4480-4486 (1986). (Pubitemid 16090665)
    • (1986) Journal of Immunology , vol.136 , Issue.12 , pp. 4480-4486
    • Lanier, L.L.1    Le, A.M.2    Civin, C.I.3
  • 104
    • 0036112623 scopus 로고    scopus 로고
    • Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation
    • Ely SA, Knowles DM. Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation. Am. J. Pathol. 160(4), 1293-1299 (2002). (Pubitemid 34411633)
    • (2002) American Journal of Pathology , vol.160 , Issue.4 , pp. 1293-1299
    • Ely, S.A.1    Knowles, D.M.2
  • 105
    • 84862304260 scopus 로고    scopus 로고
    • Efficacy of the huN901-DM1 conjugate in combination with antineoplastic agents against multiple myeloma cells in preclinical studies
    • Abstract 5577
    • Lutz R, Ab O, Foley K et al. Efficacy of the huN901-DM1 conjugate in combination with antineoplastic agents against multiple myeloma cells in preclinical studies. AACR Meeting Abstracts 2007, Abstract 5577 (2007).
    • (2007) AACR Meeting Abstracts 2007
    • Lutz, R.1    Ab, O.2    Foley, K.3
  • 106
    • 77953679586 scopus 로고    scopus 로고
    • Efficacy of IMGN901 (huN901-DM1) in combination with bortezomib and lenalidomide against multiple myeloma cells in preclinical studies
    • Abstract 2146
    • Whiteman K, Ab O, Bartle L, Foley K, Goldmacher V, Lutz R. Efficacy of IMGN901 (huN901-DM1) in combination with bortezomib and lenalidomide against multiple myeloma cells in preclinical studies. AACR Meeting Abstracts 2008, Abstract 2146 (2008).
    • (2008) AACR Meeting Abstracts 2008
    • Whiteman, K.1    Ab, O.2    Bartle, L.3    Foley, K.4    Goldmacher, V.5    Lutz, R.6
  • 107
    • 67449119398 scopus 로고    scopus 로고
    • The monoclonal antibody nBT062 conjugated to cytotoxic maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo
    • Ikeda H, Hideshima T, Fulciniti M et al. The monoclonal antibody nBT062 conjugated to cytotoxic maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin. Cancer Res. 15(12), 4028-4037 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.12 , pp. 4028-4037
    • Ikeda, H.1    Hideshima, T.2    Fulciniti, M.3
  • 108
  • 109
    • 1542330894 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • DOI 10.1016/j.bcmd.2004.01.001, PII S1079979604000038
    • Roodman GD. Pathogenesis of myeloma bone disease. Blood Cells Mol. Dis. 32(2), 290-292 (2004). (Pubitemid 38296693)
    • (2004) Blood Cells, Molecules, and Diseases , vol.32 , Issue.2 , pp. 290-292
    • Roodman, G.D.1
  • 110
    • 29244465497 scopus 로고    scopus 로고
    • Myeloma bone disease
    • DOI 10.1080/10245330512331389782
    • Sezer O. Myeloma bone disease. Hematology 10(Suppl. 1), 19-24 (2005). (Pubitemid 41825682)
    • (2005) Hematology , vol.10 , Issue.SUPPL. 1 , pp. 19-24
    • Sezer, O.1
  • 111
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • DOI 10.1038/nrc2189, PII NRC2189
    • Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat. Rev. Cancer 7(8), 585-598 (2007). (Pubitemid 47106630)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.8 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3    Richardson, P.G.4    Anderson, K.C.5
  • 115
    • 34547677725 scopus 로고    scopus 로고
    • Immunodeficiency and immunotherapy in multiple myeloma
    • DOI 10.1111/j.1365-2141.2007.06705.x
    • Pratt G, Goodyear O, Moss P. Immunodeficiency and immunotherapy in multiple myeloma. Br. J. Haematol. 138(5), 563-579 (2007). (Pubitemid 47208476)
    • (2007) British Journal of Haematology , vol.138 , Issue.5 , pp. 563-579
    • Pratt, G.1    Goodyear, O.2    Moss, P.3
  • 116
    • 0031940327 scopus 로고    scopus 로고
    • The cell surface proteoglycan syndecan-1 mediates fibroblast growth factor-2 binding and activity
    • DOI 10.1002/(SICI)1097-4652(199803)174:3<310::AID-JCP5>3.0.CO;2-R
    • Filla MS, Dam P, Rapraeger AC. The cell surface proteoglycan syndecan-1 mediates fibroblast growth factor-2 binding and activity. J. Cell. Physiol. 174(3), 310-321 (1998). (Pubitemid 28068708)
    • (1998) Journal of Cellular Physiology , vol.174 , Issue.3 , pp. 310-321
    • Filla, M.S.1    Dam, P.2    Rapraeger, A.C.3
  • 117
    • 33646076452 scopus 로고    scopus 로고
    • Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis
    • Jakobsson L, Kreuger J, Holmborn K et al. Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis. Dev. Cell 10(5), 625-634 (2006).
    • (2006) Dev. Cell. , vol.10 , Issue.5 , pp. 625-634
    • Jakobsson, L.1    Kreuger, J.2    Holmborn, K.3
  • 118
    • 84856759609 scopus 로고    scopus 로고
    • An angiogenic risk score improves the prognostic information of the international staging system in patients with symptomatic multiple myeloma
    • Abstract 2802
    • Jakob C, Wernecke T, Sterz J et al. An angiogenic risk score improves the prognostic information of the international staging system in patients with symptomatic multiple myeloma. Blood (ASH Annual Meeting Abstracts) 114(22), Abstract 2802 (2009).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , Issue.22
    • Jakob, C.1    Wernecke, T.2    Sterz, J.3
  • 119
    • 0035880256 scopus 로고    scopus 로고
    • Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
    • Podar K, Tai YT, Davies FE et al. Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. Blood 98(2), 428-435 (2001).
    • (2001) Blood , vol.98 , Issue.2 , pp. 428-435
    • Podar, K.1    Tai, Y.T.2    Davies, F.E.3
  • 120
    • 48649092981 scopus 로고    scopus 로고
    • Small-molecule inhibition of proteasome and silencing by vascular endothelial cell growth factor-specific siRNA induce additive antitumor activity in multiple myeloma
    • Koldehoff M, Beelen DW, Elmaagacli AH. Small-molecule inhibition of proteasome and silencing by vascular endothelial cell growth factor-specific siRNA induce additive antitumor activity in multiple myeloma. J. Leukoc. Biol. 84(2), 561-576 (2008).
    • (2008) J. Leukoc. Biol. , vol.84 , Issue.2 , pp. 561-576
    • Koldehoff, M.1    Beelen, D.W.2    Elmaagacli, A.H.3
  • 122
    • 56449107803 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab combined with low dose dexamethasone and lenalidomide (BEV/REV/DEX) for relapsed or refractory myeloma (MM)
    • Abstract 1173
    • Raschko M, Markovina S, Miyamoto S et al. Phase II trial of bevacizumab combined with low dose dexamethasone and lenalidomide (BEV/REV/DEX) for relapsed or refractory myeloma (MM). Blood (ASH Annual Meeting Abstracts) 110(11), Abstract 1173 (2007).
    • (2007) Blood (ASH Annual Meeting Abstracts) , vol.110 , Issue.11
    • Raschko, M.1    Markovina, S.2    Miyamoto, S.3
  • 123
    • 80052269008 scopus 로고    scopus 로고
    • The addition of bevacizumab (B) to lenalidomide and low dose dexamethasone does not significantly increase response in relapsed or refractory multiple myeloma (NCI#7317)
    • Abstract 3885
    • Callander NS, Markovina S, Juckett MB et al. The addition of bevacizumab (B) to lenalidomide and low dose dexamethasone does not significantly increase response in relapsed or refractory multiple myeloma (NCI#7317). Blood (ASH Annual Meeting Abstracts) 114(22), Abstract 3885 (2009).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , Issue.22
    • Callander, N.S.1    Markovina, S.2    Juckett, M.B.3
  • 125
    • 61649100307 scopus 로고    scopus 로고
    • The FGF family: Biology, pathophysiology and therapy
    • Beenken A, Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat. Rev. Drug Discov. 8(3), 235-253 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , Issue.3 , pp. 235-253
    • Beenken, A.1    Mohammadi, M.2
  • 126
    • 22044440001 scopus 로고    scopus 로고
    • Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in multiple myeloma
    • DOI 10.1182/blood-2005-01-0033
    • Chang H, Stewart AK, Qi XY, Li ZH, Yi QL, Trudel S. Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in multiple myeloma. Blood 106(1), 353-355 (2005). (Pubitemid 40967212)
    • (2005) Blood , vol.106 , Issue.1 , pp. 353-355
    • Chang, H.1    Stewart, A.K.2    Qi, X.Y.3    Li, Z.H.4    Yi, Q.L.5    Trudel, S.6
  • 127
    • 66449083374 scopus 로고    scopus 로고
    • FGFR3-targeted mAb therapy for bladder cancer and multiple myeloma
    • Hadari Y, Schlessinger J. FGFR3-targeted mAb therapy for bladder cancer and multiple myeloma. J. Clin. Invest. 119(5), 1077-1079 (2009).
    • (2009) J. Clin. Invest. , vol.119 , Issue.5 , pp. 1077-1079
    • Hadari, Y.1    Schlessinger, J.2
  • 128
    • 84860704229 scopus 로고    scopus 로고
    • Syndecan-1 promotes the angiogenic phenotype of multiple myeloma endothelial cells
    • Lamorte S, Ferrero S, Aschero S et al. Syndecan-1 promotes the angiogenic phenotype of multiple myeloma endothelial cells. Leukemia 26(5), 1081-1090 (2012).
    • (2012) Leukemia. , vol.26 , Issue.5 , pp. 1081-1090
    • Lamorte, S.1    Ferrero, S.2    Aschero, S.3
  • 129
    • 28044442504 scopus 로고    scopus 로고
    • Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: Growth regulation and the prospect of new cancer therapies
    • DOI 10.1002/jcb.20602
    • Sanderson RD, Yang Y, Kelly T, Macleod V, Dai Y, Theus A. Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies. J. Cell. Biochem. 96(5), 897-905 (2005). (Pubitemid 41688716)
    • (2005) Journal of Cellular Biochemistry , vol.96 , Issue.5 , pp. 897-905
    • Sanderson, R.D.1    Yang, Y.2    Kelly, T.3    MacLeod, V.4    Dai, Y.5    Theus, A.6
  • 130
    • 35548965151 scopus 로고    scopus 로고
    • Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies
    • DOI 10.1038/sj.leu.2404821, PII 2404821
    • Ostrovsky O, Korostishevsky M, Levite I et al. Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies. Leukemia 21(11), 2296-2303 (2007). (Pubitemid 350011702)
    • (2007) Leukemia , vol.21 , Issue.11 , pp. 2296-2303
    • Ostrovsky, O.1    Korostishevsky, M.2    Levite, I.3    Leiba, M.4    Galski, H.5    Vlodavsky, I.6    Nagler, A.7
  • 132
    • 74949138353 scopus 로고    scopus 로고
    • Effect of VEGF antisense RNA on inducing apoptosis of myeloma cells and inhibition of angiogenesis in endothelial cells in vitro
    • Huang HB, Zhan R. Effect of VEGF antisense RNA on inducing apoptosis of myeloma cells and inhibition of angiogenesis in endothelial cells in vitro. Zhongguo Shi Yan Xue Ye Xue Za Zhi 16(2), 312-316 (2008).
    • (2008) Zhongguo Shi Yan Xue Ye Xue Za Zhi. , vol.16 , Issue.2 , pp. 312-316
    • Huang, H.B.1    Zhan, R.2
  • 133
    • 80054991119 scopus 로고    scopus 로고
    • The selective adhesion molecule inhibitor natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: Therapeutic implications
    • Podar K, Zimmerhackl A, Fulciniti M et al. The selective adhesion molecule inhibitor natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications. Br. J. Haematol. 155(4), 438-448 (2011).
    • (2011) Br. J. Haematol. , vol.155 , Issue.4 , pp. 438-448
    • Podar, K.1    Zimmerhackl, A.2    Fulciniti, M.3
  • 135
    • 27944496481 scopus 로고    scopus 로고
    • Management of bone metastases in cancer: A review
    • DOI 10.1016/j.critrevonc.2005.03.011, PII S1040842805000661
    • Selvaggi G, Scagliotti GV. Management of bone metastases in cancer: a review. Crit. Rev. Oncol. Hematol. 56(3), 365-378 (2005). (Pubitemid 41677618)
    • (2005) Critical Reviews in Oncology/Hematology , vol.56 , Issue.3 , pp. 365-378
    • Selvaggi, G.1    Scagliotti, G.V.2
  • 136
    • 70349488703 scopus 로고    scopus 로고
    • An open-label, Phase II trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma
    • Vij R, Horvath N, Spencer A et al. An open-label, Phase II trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma. Am. J. Hematol. 84(10), 650-656 (2009).
    • (2009) Am. J. Hematol. , vol.84 , Issue.10 , pp. 650-656
    • Vij, R.1    Horvath, N.2    Spencer, A.3
  • 137
    • 79952761418 scopus 로고    scopus 로고
    • Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
    • Henry DH, Costa L, Goldwasser F et al. Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J. Clin. Oncol. 29(9), 1125-1132 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.9 , pp. 1125-1132
    • Henry, D.H.1    Costa, L.2    Goldwasser, F.3
  • 140
    • 40849083276 scopus 로고    scopus 로고
    • Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    • Qiang YW, Barlogie B, Rudikoff S, Shaughnessy JD Jr. Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone 42(4), 669-680 (2008).
    • (2008) Bone. , vol.42 , Issue.4 , pp. 669-680
    • Qiang, Y.W.1    Barlogie, B.2    Rudikoff, S.3    Shaughnessy Jr., J.D.4
  • 142
    • 67650431302 scopus 로고    scopus 로고
    • Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
    • Fulciniti M, Tassone P, Hideshima T et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 114(2), 371-379 (2009).
    • (2009) Blood , vol.114 , Issue.2 , pp. 371-379
    • Fulciniti, M.1    Tassone, P.2    Hideshima, T.3
  • 143
    • 61849137831 scopus 로고    scopus 로고
    • Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma
    • Heath DJ, Chantry AD, Buckle CH et al. Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma. J. Bone Miner. Res. 24(3), 425-436 (2009).
    • (2009) J. Bone Miner. Res. , vol.24 , Issue.3 , pp. 425-436
    • Heath, D.J.1    Chantry, A.D.2    Buckle, C.H.3
  • 144
    • 0026070258 scopus 로고
    • Allogeneic bone marrow transplantation in multiple myeloma. European Group for Bone Marrow Transplantation
    • Gahrton G, Tura S, Ljungman P et al. Allogeneic bone marrow transplantation in multiple myeloma. European Group for Bone Marrow Transplantation. N. Engl. J. Med. 325(18), 1267-1273 (1991).
    • (1991) N. Engl. J. Med. , vol.325 , Issue.18 , pp. 1267-1273
    • Gahrton, G.1    Tura, S.2    Ljungman, P.3
  • 145
    • 34147144964 scopus 로고    scopus 로고
    • Reduced-intensity conditioning for myeloma: Lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning
    • DOI 10.1182/blood-2006-07-036848
    • Crawley C, Iacobelli S, Bjorkstrand B, Apperley JF, Niederwieser D, Gahrton G. Reduced-intensity conditioning for myeloma: lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning. Blood 109(8), 3588-3594 (2007). (Pubitemid 46572554)
    • (2007) Blood , vol.109 , Issue.8 , pp. 3588-3594
    • Crawley, C.1    Iacobelli, S.2    Bjorkstrand, B.3    Apperley, J.F.4    Niederwieser, D.5    Gahrton, G.6
  • 146
    • 0032895599 scopus 로고    scopus 로고
    • Molecular and clinical remissions in multiple myeloma: Role of autologous and allogeneic transplantation of hematopoietic cells
    • Corradini P, Voena C, Tarella C et al. Molecular and clinical remissions in multiple myeloma: role of autologous and allogeneic transplantation of hematopoietic cells. J. Clin. Oncol. 17(1), 208-215 (1999). (Pubitemid 29022395)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.1 , pp. 208-215
    • Corradini, P.1    Voena, C.2    Tarella, C.3    Astolfi, M.4    Ladetto, M.5    Palumbo, A.6    Van7
  • 148
    • 24944449622 scopus 로고    scopus 로고
    • Immunotherapy in multiple myeloma-possibility or probability?
    • Harrison SJ, Cook G. Immunotherapy in multiple myeloma-possibility or probability? Br. J. Haematol. 130(3), 344-362 (2005).
    • (2005) Br. J. Haematol. , vol.130 , Issue.3 , pp. 344-362
    • Harrison, S.J.1    Cook, G.2
  • 149
    • 77955366845 scopus 로고    scopus 로고
    • Allogenic hematopoietic stem-cell transplantation with reduced-intensity conditioning in patients with refractory and recurrent multiple myeloma: Long-term follow-up
    • Shimoni A, Hardan I, Ayuk F et al. Allogenic hematopoietic stem-cell transplantation with reduced-intensity conditioning in patients with refractory and recurrent multiple myeloma: long-term follow-up. Cancer 116(15), 3621-3630 (2010).
    • (2010) Cancer. , vol.116 , Issue.15 , pp. 3621-3630
    • Shimoni, A.1    Hardan, I.2    Ayuk, F.3
  • 151
    • 33646401089 scopus 로고    scopus 로고
    • Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma
    • Garban F, Attal M, Michallet M et al. Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma. Blood 107(9), 3474-3480 (2006).
    • (2006) Blood , vol.107 , Issue.9 , pp. 3474-3480
    • Garban, F.1    Attal, M.2    Michallet, M.3
  • 157
    • 0033665539 scopus 로고    scopus 로고
    • Donor leukocyte infusions for multiple myeloma
    • Salama M, Nevill T, Marcellus D et al. Donor leukocyte infusions for multiple myeloma. Bone Marrow Transplant. 26(11), 1179-1184 (2000).
    • (2000) Bone Marrow Transplant. , vol.26 , Issue.11 , pp. 1179-1184
    • Salama, M.1    Nevill, T.2    Marcellus, D.3
  • 158
    • 1542608518 scopus 로고    scopus 로고
    • Efficacy and toxicity of low-dose escalating donor lymphocyte infusion given after reduced intensity conditioning allograft for multiple myeloma [8]
    • DOI 10.1038/sj.leu.2403252
    • Ayuk F, Shimoni A, Nagler A et al. Efficacy and toxicity of low-dose escalating donor lymphocyte infusion given after reduced intensity conditioning allograft for multiple myeloma. Leukemia 18(3), 659-662 (2004). (Pubitemid 38425889)
    • (2004) Leukemia , vol.18 , Issue.3 , pp. 659-662
    • Ayuk, F.1    Shimoni, A.2    Nagler, A.3    Schwerdtfeger, R.4    Kiehl, M.5    Sayer, H.G.6    Zabelina, T.7    Zander, A.R.8    Kroger, N.9
  • 161
    • 67349225687 scopus 로고    scopus 로고
    • Post-transplant immunotherapy with donor-lymphocyte infusion and novel agents to upgrade partial into complete and molecular remission in allografted patients with multiple myeloma
    • Kroger N, Badbaran A, Lioznov M et al. Post-transplant immunotherapy with donor-lymphocyte infusion and novel agents to upgrade partial into complete and molecular remission in allografted patients with multiple myeloma. Exp. Hematol. 37(7), 791-798 (2009).
    • (2009) Exp. Hematol. , vol.37 , Issue.7 , pp. 791-798
    • Kroger, N.1    Badbaran, A.2    Lioznov, M.3
  • 162
    • 43749108158 scopus 로고    scopus 로고
    • Reply to 'Rituximab activity in CD20-positive multiple myeloma'
    • DOI 10.1038/sj.leu.2405011, PII 2405011
    • Gozzetti A, Fabbri A, Lazzi S, Bocchia M, Lauria F. Reply to 'Rituximab activity in CD20-positive multiple myeloma'. Leukemia 22(5), 1083; author reply 1083-1084 (2008). (Pubitemid 351689900)
    • (2008) Leukemia , vol.22 , Issue.5 , pp. 1083
    • Gozzetti, A.1    Fabbri, A.2    Lazzi, S.3    Bocchia, M.4    Lauria, F.5
  • 163
    • 45549101709 scopus 로고    scopus 로고
    • Multiple myeloma cancer stem cells
    • Huff CA, Matsui W. Multiple myeloma cancer stem cells. J. Clin. Oncol. 26(17), 2895-2900 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.17 , pp. 2895-2900
    • Huff, C.A.1    Matsui, W.2
  • 164
    • 73349092717 scopus 로고    scopus 로고
    • NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients
    • Johansson SE, Hejdeman B, Hinkula J et al. NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients. Clin. Immunol. 134(2), 158-168 (2010).
    • (2010) Clin. Immunol. , vol.134 , Issue.2 , pp. 158-168
    • Johansson, S.E.1    Hejdeman, B.2    Hinkula, J.3
  • 165
    • 69249108787 scopus 로고    scopus 로고
    • Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells
    • Romagne F, Andre P, Spee P et al. Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood 114(13), 2667-2677 (2009).
    • (2009) Blood , vol.114 , Issue.13 , pp. 2667-2677
    • Romagne, F.1    Andre, P.2    Spee, P.3
  • 166
    • 70349481310 scopus 로고    scopus 로고
    • Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma
    • Van Rhee F, Szmania SM, Dillon M et al. Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma. Mol. Cancer Ther. 8(9), 2616-2624 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.9 , pp. 2616-2624
    • Van Rhee, F.1    Szmania, S.M.2    Dillon, M.3


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