메뉴 건너뛰기




Volumn 30, Issue 4, 2012, Pages 445-452

The 39th David A. Karnofsky lecture: Bench-to-bedside translation of targeted therapies in multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BHQ 880; BORTEZOMIB; CARFILZOMIB; DARATUMUMAB; DELANZOMIB; DENDRITIC CELL VACCINE; ELOTUZUMAB; HISTONE DEACETYLASE INHIBITOR; IMMUNOTOXIN; IMMUNOTOXIN CD138DM; LENALIDOMIDE; LUCATUMUMAB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MLN 2238; MLN 9708; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5592; MONOCLONAL ANTIBODY DKK1; ONYX 0912; ONYX 912; P 5091; PEPTIDE VACCINE; POMALIDAMIDE; PROTEASOME INHIBITOR; PROTEIN CS 1; PROTEIN KINASE B INHIBITOR; RAP 011; SALINOSPORAMIDE A; SYNDECAN 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; X BOX BINDING PROTEIN 1; ZOLEDRONIC ACID;

EID: 84856744110     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2011.37.8919     Document Type: Review
Times cited : (120)

References (73)
  • 1
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • DOI 10.1038/nrc2189, PII NRC2189
    • Hideshima T, Mitsiades C, Tonon G, et al: Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 7:585-598, 2007 (Pubitemid 47106630)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.8 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3    Richardson, P.G.4    Anderson, K.C.5
  • 2
    • 77449156330 scopus 로고    scopus 로고
    • The evolution and impact of therapy in multiple myeloma
    • Laubach JP, Richardson PG, Anderson KC: The evolution and impact of therapy in multiple myeloma. Med Oncol 27:S1-S6, 2010 (suppl 1)
    • (2010) Med Oncol , vol.27 , Issue.SUPPL. 1
    • Laubach, J.P.1    Richardson, P.G.2    Anderson, K.C.3
  • 3
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • Kumar SK, Rajkumar SV, Dispenzieri A, et al: Improved survival in multiple myeloma and the impact of novel therapies. Blood 111:2516-2520, 2008
    • (2008) Blood , vol.111 , pp. 2516-2520
    • Kumar, S.K.1    Rajkumar, S.V.2    Dispenzieri, A.3
  • 4
    • 27244441804 scopus 로고    scopus 로고
    • Development of effective new treatments for multiple myeloma
    • Anderson KC, Pazdur R, Farrell AT: Development of effective new treatments for multiple myeloma. J Clin Oncol 28:7207-7211, 2005
    • (2005) J Clin Oncol , vol.28 , pp. 7207-7211
    • Anderson, K.C.1    Pazdur, R.2    Farrell, A.T.3
  • 5
    • 0021272605 scopus 로고
    • Expression of human B cell-associated antigens on leukemias and lymphomas: A model of human B cell differentiation
    • Anderson KC, Bates MP, Slaughenhoupt B, et al: Expression of human B cell associated antigens on leukemias and lymphomas: A model of human B cell differentiation. Blood 63:1424-1433, 1984 (Pubitemid 14120390)
    • (1984) Blood , vol.63 , Issue.6 , pp. 1424-1433
    • Anderson, K.C.1    Bates, M.P.2    Slaughenhoupt, B.L.3
  • 6
    • 0021282111 scopus 로고
    • A monoclonal antibody with reactivity restricted to normal and neoplastic plasma cells
    • Anderson KC, Bates MP, Slaughenhoupt B, et al: A monoclonal antibody with reactivity restricted to normal and neoplastic plasma cells. J Immunol 32:3172-3179, 1984 (Pubitemid 14104289)
    • (1984) Journal of Immunology , vol.132 , Issue.6 , pp. 3172-3179
    • Anderson, K.C.1    Bates, M.P.2    Slaughenhoupt, B.3
  • 7
    • 0026016123 scopus 로고
    • Monoclonal antibody purged autologous bone marrow transplantation therapy for multiple myeloma
    • Anderson KC, Barut BA, Ritz J, et al: Monoclonal antibody purged autologous bone marrow transplantation therapy for multiple myeloma. Blood 77:712-720, 1991
    • (1991) Blood , vol.77 , pp. 712-720
    • Anderson, K.C.1    Barut, B.A.2    Ritz, J.3
  • 10
    • 85102089615 scopus 로고    scopus 로고
    • Recent advances in the biology and treatment of multiple myeloma
    • Rabb M, Podar K, Breitreutz I, et al: Recent advances in the biology and treatment of multiple myeloma. Lancet 374:324-339, 2009
    • (2009) Lancet , vol.374 , pp. 324-339
    • Rabb, M.1    Podar, K.2    Breitreutz, I.3
  • 12
    • 84861690919 scopus 로고    scopus 로고
    • Antibody-based therapies in multiple myeloma
    • epub ahead of print on March 11, 2011
    • Tai YT, Anderson KC: Antibody-based therapies in multiple myeloma. Bone Marrow Res [epub ahead of print on March 11, 2011]
    • Bone Marrow Res
    • Tai, Y.T.1    Anderson, K.C.2
  • 13
    • 51649083849 scopus 로고    scopus 로고
    • Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
    • Tai YT, Dillon M, Song W, et al: Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. Blood 112:1329-1337, 2008
    • (2008) Blood , vol.112 , pp. 1329-1337
    • Tai, Y.T.1    Dillon, M.2    Song, W.3
  • 14
    • 67449119398 scopus 로고    scopus 로고
    • The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138- positive multiple myeloma cells in vitro and in vivo
    • Ikeda H, Hideshima T, Fulciniti M, et al: The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138- positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res 15:4028-4037, 2009
    • (2009) Clin Cancer Res , vol.15 , pp. 4028-4037
    • Ikeda, H.1    Hideshima, T.2    Fulciniti, M.3
  • 16
    • 78751510278 scopus 로고    scopus 로고
    • Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma
    • Rosenblatt J, Vasir B, Uhl L, et al: Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma. Blood 117:393-402, 2011
    • (2011) Blood , vol.117 , pp. 393-402
    • Rosenblatt, J.1    Vasir, B.2    Uhl, L.3
  • 17
    • 80054029555 scopus 로고    scopus 로고
    • Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: Potential therapeutic application in multiple myeloma
    • Bae J, Carrasco R, Lee AH, et al: Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: Potential therapeutic application in multiple myeloma. Leukemia 25:1610-1619, 2011
    • (2011) Leukemia , vol.25 , pp. 1610-1619
    • Bae, J.1    Carrasco, R.2    Lee, A.H.3
  • 18
    • 77955862810 scopus 로고    scopus 로고
    • Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma
    • Prabhala RH, Pelluru D, Fulciniti M, et al: Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma. Blood 115:5385-5392, 2010
    • (2010) Blood , vol.115 , pp. 5385-5392
    • Prabhala, R.H.1    Pelluru, D.2    Fulciniti, M.3
  • 19
    • 70349577375 scopus 로고    scopus 로고
    • Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: A therapeutic target
    • Chauhan D, Singh AV, Brahmandam M, et al: Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: A therapeutic target. Cancer Cell 16:309-323, 2009
    • (2009) Cancer Cell , vol.16 , pp. 309-323
    • Chauhan, D.1    Singh, A.V.2    Brahmandam, M.3
  • 22
  • 23
    • 77950542260 scopus 로고    scopus 로고
    • Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity
    • McMillin DW, Delmore J, Weisberg E, et al: Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity. Nat Med 16:483-489
    • Nat Med , vol.16 , pp. 483-489
    • McMillin, D.W.1    Delmore, J.2    Weisberg, E.3
  • 27
    • 43249127114 scopus 로고    scopus 로고
    • Targeting proteasomes as therapy in multiple myeloma
    • Chauhan D, Hideshima T, Anderson KC: Targeting proteasomes as therapy in multiple myeloma. Adv Exp Med Biol 615:251-260, 2008
    • (2008) Adv Exp Med Biol , vol.615 , pp. 251-260
    • Chauhan, D.1    Hideshima, T.2    Anderson, K.C.3
  • 30
    • 33750607347 scopus 로고    scopus 로고
    • A randomized phase 2 trial of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma
    • Richardson P, Blood E, Mitsiades CS, et al: A randomized phase 2 trial of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. Blood 15:3458-3464, 2006
    • (2006) Blood , vol.15 , pp. 3458-3464
    • Richardson, P.1    Blood, E.2    Mitsiades, C.S.3
  • 31
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel JF, Schlag R, Khuageva NK, et al: Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med 359:906-917, 2008
    • (2008) N Engl J Med , vol.359 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 33
    • 63849281664 scopus 로고    scopus 로고
    • The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition
    • Bianchi G, Oliva L, Cascio P, et al: The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition. Blood 113:3040-3049, 2009
    • (2009) Blood , vol.113 , pp. 3040-3049
    • Bianchi, G.1    Oliva, L.2    Cascio, P.3
  • 34
    • 70350708810 scopus 로고    scopus 로고
    • Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
    • Parlati F, Lee SJ, Aujay M, et al: Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood 114:3439-3447, 2009
    • (2009) Blood , vol.114 , pp. 3439-3447
    • Parlati, F.1    Lee, S.J.2    Aujay, M.3
  • 35
    • 65649139708 scopus 로고    scopus 로고
    • Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047)
    • Zhou HJ, Aujay MA, Bennett MK, et al: Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). J Med Chem 52:3028-3038, 2009
    • (2009) J Med Chem , vol.52 , pp. 3028-3038
    • Zhou, H.J.1    Aujay, M.A.2    Bennett, M.K.3
  • 36
    • 78649755360 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
    • Chauhan D, Singh AV, Aujay M, et al: A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood 116:4906-4915, 2010
    • (2010) Blood , vol.116 , pp. 4906-4915
    • Chauhan, D.1    Singh, A.V.2    Aujay, M.3
  • 37
    • 80051691845 scopus 로고    scopus 로고
    • In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells
    • Chauhan D, Tian Z, Zhou B, et al: In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells. Clin Cancer Res 17:5311- 5321, 2011
    • (2011) Clin Cancer Res , vol.17 , pp. 5311-5321
    • Chauhan, D.1    Tian, Z.2    Zhou, B.3
  • 39
    • 72549116835 scopus 로고    scopus 로고
    • A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies
    • O'Connor OA, Stewart AK, Vallone M, et al: A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies. Clin Cancer Res 15:7085-7091, 2009
    • (2009) Clin Cancer Res , vol.15 , pp. 7085-7091
    • O'Connor, O.A.1    Stewart, A.K.2    Vallone, M.3
  • 40
    • 78650348146 scopus 로고    scopus 로고
    • PR-924, a selective inhibitor of the immunoproteasome sub-unit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo
    • Singh AV, Bandi M, Aujay MA, et al: PR-924, a selective inhibitor of the immunoproteasome sub-unit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo. Br J Haematol 152:155-163, 2011
    • (2011) Br J Haematol , vol.152 , pp. 155-163
    • Singh, A.V.1    Bandi, M.2    Aujay, M.A.3
  • 41
    • 0034331194 scopus 로고    scopus 로고
    • Thalidomide and its analogues overcome drug resistance of human multiple myeloma cells to conventional therapy
    • Hideshima T, Chauhan D, Shima Y, et al: Thalidomide and its analogues overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood 96:2943-2950, 2000
    • (2000) Blood , vol.96 , pp. 2943-2950
    • Hideshima, T.1    Chauhan, D.2    Shima, Y.3
  • 43
    • 78049386125 scopus 로고    scopus 로고
    • Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma
    • Görgün G, Calabrese E, Soydan E, et al: Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma. Blood 116:3227-3237, 2010
    • (2010) Blood , vol.116 , pp. 3227-3237
    • Görgün, G.1    Calabrese, E.2    Soydan, E.3
  • 44
    • 36349010285 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
    • Weber DM, Chen C, Niesvizky R, et al: Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N Engl J Med 357:2133- 2142, 2007
    • (2007) N Engl J Med , vol.357 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3
  • 46
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S, et al: Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 116:679-686, 2010
    • (2010) Blood , vol.116 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 47
    • 78650993336 scopus 로고    scopus 로고
    • Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: A randomized controlled trial
    • Palumbo A, Bringhen S, Rossi D, et al: Bortezomib-melphalan-prednisone- thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: A randomized controlled trial. J Clin Oncol 28:5101-5109, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 5101-5109
    • Palumbo, A.1    Bringhen, S.2    Rossi, D.3
  • 48
    • 77957583471 scopus 로고    scopus 로고
    • First-line treatment of elderly multiple myeloma patients
    • Palumbo A: First-line treatment of elderly multiple myeloma patients. Clin Adv Hematol Oncol 8:529-530, 2010
    • (2010) Clin Adv Hematol Oncol , vol.8 , pp. 529-530
    • Palumbo, A.1
  • 49
    • 73249146496 scopus 로고    scopus 로고
    • Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: An open-label randomised controlled trial
    • Rajkumar SV, Jacobus S, Callander NS, et al: Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: An open-label randomised controlled trial. Lancet Oncol 11:29-37, 2010
    • (2010) Lancet Oncol , vol.11 , pp. 29-37
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.S.3
  • 50
    • 33745291854 scopus 로고    scopus 로고
    • Oral revlimid plus melphalan and prednisone for newly diagnosed multiple myeloma
    • Palumbo A, Falco P, Musto P, et al: Oral revlimid plus melphalan and prednisone for newly diagnosed multiple myeloma. Blood 106:231a, 2005
    • (2005) Blood , vol.106
    • Palumbo, A.1    Falco, P.2    Musto, P.3
  • 51
    • 73849086725 scopus 로고    scopus 로고
    • Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma
    • Lacy MQ, Hayman SR, Gertz MA, et al: Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma. J Clin Oncol 27:5008-5014, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 5008-5014
    • Lacy, M.Q.1    Hayman, S.R.2    Gertz, M.A.3
  • 52
    • 78149468560 scopus 로고    scopus 로고
    • Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM)
    • Lacy MQ, Hayman SR, Gertz MA, et al: Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM). Leukemia 24:1934-1939, 2010
    • (2010) Leukemia , vol.24 , pp. 1934-1939
    • Lacy, M.Q.1    Hayman, S.R.2    Gertz, M.A.3
  • 53
    • 54049156803 scopus 로고    scopus 로고
    • Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma
    • Breitkreutz I, Raab MS, Vallet S, et al: Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia 22:1925-1932, 2008
    • (2008) Leukemia , vol.22 , pp. 1925-1932
    • Breitkreutz, I.1    Raab, M.S.2    Vallet, S.3
  • 54
    • 79952721484 scopus 로고    scopus 로고
    • Advances in the biology and treatment of bone disease in multiple myeloma
    • Raje N, Roodman GD: Advances in the biology and treatment of bone disease in multiple myeloma. Clin Cancer Res 17:1278-1286, 2011
    • (2011) Clin Cancer Res , vol.17 , pp. 1278-1286
    • Raje, N.1    Roodman, G.D.2
  • 55
    • 67650431302 scopus 로고    scopus 로고
    • Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
    • Fulciniti M, Tassone P, Hideshima T, et al: Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 114:371-379, 2009
    • (2009) Blood , vol.114 , pp. 371-379
    • Fulciniti, M.1    Tassone, P.2    Hideshima, T.3
  • 61
    • 67349099081 scopus 로고    scopus 로고
    • Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma
    • Raje N, Hideshima T, Mukherjee S, et al: Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma. Leukemia 23:961- 970, 2009
    • (2009) Leukemia , vol.23 , pp. 961-970
    • Raje, N.1    Hideshima, T.2    Mukherjee, S.3
  • 62
    • 79952042047 scopus 로고    scopus 로고
    • Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: A multicentre, phase 1/2, open-label, dose-escalation study
    • Ghobrial IM, Weller E, Vij R, et al: Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: A multicentre, phase 1/2, open-label, dose-escalation study. Lancet Oncol 12:263-272, 2011
    • (2011) Lancet Oncol , vol.12 , pp. 263-272
    • Ghobrial, I.M.1    Weller, E.2    Vij, R.3
  • 64
    • 33751172982 scopus 로고    scopus 로고
    • Aggresome induction by proteasome inhibitor bortezomib and tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
    • Catley L, Weisberg E, Kiziltepe T, et al: Aggresome induction by proteasome inhibitor bortezomib and tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 108:3441-3449, 2006
    • (2006) Blood , vol.108 , pp. 3441-3449
    • Catley, L.1    Weisberg, E.2    Kiziltepe, T.3
  • 65
    • 29344447032 scopus 로고    scopus 로고
    • Intracellular protein degradation and its therapeutic implications
    • DOI 10.1158/1078-0432.CCR-05-2305
    • Hideshima T, Bradner JE, Chauhan D, et al: Intracellular protein degradation and its therapeutic implications. Clin Cancer Res 11:8530-8533, 2005 (Pubitemid 43005896)
    • (2005) Clinical Cancer Research , vol.11 , Issue.24 , pp. 8530-8533
    • Hideshima, T.1    Bradner, J.E.2    Chauhan, D.3    Anderson, K.C.4
  • 69
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/ refractory multiple myeloma
    • Richardson PG, Weller E, Jagannath S, et al: Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/ refractory multiple myeloma. J Clin Oncol 27:5713- 5719, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3
  • 71
    • 33645769276 scopus 로고    scopus 로고
    • High-resolution genomic profiles defines distinct clinico-pathogenetic subgroups of multiple myeloma patients
    • Carrasco DR, Tonon G, Huang Y, et al: High-resolution genomic profiles defines distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell 9:313-325, 2006
    • (2006) Cancer Cell , vol.9 , pp. 313-325
    • Carrasco, D.R.1    Tonon, G.2    Huang, Y.3
  • 72
    • 74549190701 scopus 로고    scopus 로고
    • Prognostic significance of copy-number alterations in multiple myeloma
    • Avet-Loiseau H, Li C, Magrangeas F, et al: Prognostic significance of copy-number alterations in multiple myeloma. J Clin Oncol 27:4585-4590, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 4585-4590
    • Avet-Loiseau, H.1    Li, C.2    Magrangeas, F.3
  • 73
    • 79951494668 scopus 로고    scopus 로고
    • Initial genome sequencing and analysis of multiple myeloma
    • Chapman MA, Lawrence MS, Keats JJ, et al: Initial genome sequencing and analysis of multiple myeloma. Nature 471:467-472, 2011
    • (2011) Nature , vol.471 , pp. 467-472
    • Chapman, M.A.1    Lawrence, M.S.2    Keats, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.