Analysis of LGR4 Receptor Distribution in Human and Mouse Tissues

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Yi, Jing ^a   Xiong, Wei ^a   Gong, Xing ^a   Bellister, Seth ^b   Ellis, Lee M ^b   Liu, Qingyun ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 4; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; EPIDERMIS; EPITHELIUM CELL; FLUORESCENCE ACTIVATED CELL SORTING; GENITAL SYSTEM; GERM CELL; HAIR FOLLICLE; HAPLOTYPE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTESTINE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; RAT; RISK FACTOR; SIGNAL TRANSDUCTION; SKIN; TISSUE DISTRIBUTION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; FEMALE; HAPLOTYPES; HCT116 CELLS; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; RATS; RECEPTORS, G-PROTEIN-COUPLED; SKIN;

EID: 84886913102     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078144     Document Type: Article

References (41)

1. Mazerbourg S, Bouley DM, Sudo S, Klein CA, Zhang JV, et al. (2004) Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol Endocrinol 18: 2241-2254. doi:10.1210/me.2004-0133. PubMed: 15192078.
2. Kato S, Matsubara M, Matsuo T, Mohri Y, Kazama I, et al. (2006) Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice. Nephron Exp Nephrol 104: e63-e75. doi:10.1159/000093999. PubMed: 16785743.
3. Mendive F, Laurent P, Van Schoore G, Skarnes W, Pochet R, et al. (2006) Defective postnatal development of the male reproductive tract in LGR4 knockout mice. Dev Biol 290: 421-434. doi:10.1016/j.ydbio.2005.11.043. PubMed: 16406039.
4. Hoshii T, Takeo T, Nakagata N, Takeya M, Araki K, et al. (2007) LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice. Biol Reprod 76: 303-313. doi:10.1095/biolreprod.106.054619. PubMed: 17079737.
5. Mohri Y, Kato S, Umezawa A, Okuyama R, Nishimori K, (2008) Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4. Dev Dyn 237: 2235-2242. doi:10.1002/dvdy.21639. PubMed: 18651655.
6. Mohri Y, Umezu T, Hidema S, Tomisawa H, Akamatsu A, et al. (2010) Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues. Fertil Steril 94: 2878-2881. doi:10.1016/j.fertnstert.2010.05.050. PubMed: 20638054.
7. Weng J, Luo J, Cheng X, Jin C, Zhou X, et al. (2008) Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A 105: 6081-6086. doi:10.1073/pnas.0708257105. PubMed: 18424556.
8. Oyama K, Mohri Y, Sone M, Nawa A, Nishimori K, (2011) Conditional knockout of Lgr4 leads to impaired ductal elongation and branching morphogenesis in mouse mammary glands. Sex Dev 5: 205-212. doi:10.1159/000329476. PubMed: 21791950.
9. Mustata RC, Van Loy T, Lefort A, Libert F, Strollo S, et al. (2011) Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo. EMBO Rep, 12: 558-64. PubMed: 21508962.
10. Yamashita R, Takegawa Y, Sakumoto M, Nakahara M, Kawazu H, et al. (2009) Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice. Dev Dyn 238: 993-1000. doi:10.1002/dvdy.21900. PubMed: 19301403.
11. Styrkarsdottir U, Thorleifsson G, Sulem P, Gudbjartsson DF, Sigurdsson A, et al. (2013) Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits. Nature, 497: 517-20. PubMed: 23644456.
12. Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007. doi:10.1038/nature06196. PubMed: 17934449.
13. de Lau W, Barker N, Low TY, Koo BK, Li VS, et al. (2011) Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 476: 293-297. doi:10.1038/nature10337. PubMed: 21727895.
14. Carmon KS, Gong X, Lin Q, Thomas A, Liu Q, (2011) R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A 108: 11452-11457. doi:10.1073/pnas.1106083108. PubMed: 21693646.
15. Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, et al. (2011) LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling. EMBO Rep 12: 1055-1061. doi:10.1038/embor.2011.175. PubMed: 21909076.
16. Ruffner H, Sprunger J, Charlat O, Leighton-Davies J, Grosshans B, et al. (2012) R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5. PLOS ONE 7: e40976. doi:10.1371/journal.pone.0040976. PubMed: 22815884.
17. MacDonald BT, Tamai K, He X, (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9-26. doi:10.1016/j.devcel.2009.06.016. PubMed: 19619488.
18. Nusse R, Fuerer C, Ching W, Harnish K, Logan C, et al. (2008) Wnt signaling and stem cell control. Cold Spring Harb Symp Quant Biol 73: 59-66. doi:10.1101/sqb.2008.73.035. PubMed: 19028988.
19. Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113. doi:10.1126/science.1145720. PubMed: 17932254.
20. Seshagiri S, Stawiski EW, Durinck S, Modrusan Z, Storm EE, et al. (2012) Recurrent R-spondin fusions in colon cancer. Nature 488: 660-664. doi:10.1038/nature11282. PubMed: 22895193.
21. Van Schoore G, Mendive F, Pochet R, Vassart G, (2005) Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse. Histochem Cell Biol 124: 35-50. doi:10.1007/s00418-005-0002-3. PubMed: 16028069.
22. Barker N, Clevers H, (2010) Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology 138: 1681-1696. doi:10.1053/j.gastro.2010.03.002. PubMed: 20417836.
23. Gong X, Carmon KS, Lin Q, Thomas A, Yi J, et al. (2012) LGR6 Is a High Affinity Receptor of R-Spondins and Potentially Functions as a Tumor Suppressor. PLOS ONE 7: e37137. doi:10.1371/journal.pone.0037137. PubMed: 22615920.
24. Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, et al. (2012) The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483: 603-607. doi:10.1038/nature11003. PubMed: 22460905.
25. Parma P, Radi O, Vidal V, Chaboissier MC, Dellambra E, et al. (2006) R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat Genet 38: 1304-1309. doi:10.1038/ng1907. PubMed: 17041600.
26. Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, et al. (2010) Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 327: 1385-1389. doi:10.1126/science.1184733. PubMed: 20223988.
27. Cheng Y, Kawamura K, Takae S, Deguchi M, Yang Q, et al. (2013) Oocyte-derived R-spondin2 promotes ovarian follicle development. FASEB J, 27: 2175-84. PubMed: 23407710.
28. Wang Y, Dong J, Li D, Lai L, Siwko S, et al. (2013) Lgr4 Regulates Mammary Gland Development and Stem Cell Activity through the Pluripotency Transcription Factor Sox2. Stem Cells, 31: 1921-1931. PubMed: 23712846.
29. Qian Y, Liu S, Guan Y, Pan H, Guan X, et al. (2013) Lgr4-mediated Wnt/beta-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development 140: 1751-1761. doi:10.1242/dev.093641. PubMed: 23533175.
30. Liu S, Qian Y, Li L, Wei G, Guan Y, et al. (2013) Lgr4 Gene Deficiency Increases Susceptibility and Severity of Dextran Sodium Sulfate-induced Inflammatory Bowel Disease in Mice. J Biol Chem 288: 8794-8803. doi:10.1074/jbc.M112.436204. PubMed: 23393138.
31. Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, et al. (2011) Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469: 415-418. doi:10.1038/nature09637. PubMed: 21113151.
32. Gao Y, Kitagawa K, Hiramatsu Y, Kikuchi H, Isobe T, et al. (2006) Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res 66: 11623-11631. doi:10.1158/0008-5472.CAN-06-2629. PubMed: 17178856.
33. Wong VS, Yeung A, Schultz W, Brubaker PL, (2010) R-spondin-1 is a novel beta-cell growth factor and insulin secretagogue. J Biol Chem 285: 21292-21302. doi:10.1074/jbc.M110.129874. PubMed: 20442404.
34. Aly H, Rohatgi N, Marshall CA, Grossenheider TC, Miyoshi H, et al. (2013) A Novel Strategy to Increase the Proliferative Potential of Adult Human beta-Cells While Maintaining Their Differentiated Phenotype. PLOS ONE 8: e66131. doi:10.1371/journal.pone.0066131. PubMed: 23776620.
35. Hsu SY, Liang SG, Hsueh AJ, (1998) Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Mol Endocrinol 12: 1830-1845. doi:10.1210/me.12.12.1830. PubMed: 9849958.
36. Wang J, Li X, Ke Y, Lu Y, Wang F, et al. (2012) GPR48 increases mineralocorticoid receptor gene expression. J Am Soc Nephrol 23: 281-293. doi:10.1681/ASN.2011040351. PubMed: 22135314.
37. Polakis P, (2007) The many ways of Wnt in cancer. Curr Opin Genet Dev 17: 45-51. doi:10.1016/j.gde.2006.12.007. PubMed: 17208432.
38. Srinivasan V, Ma K, Adams MW, Newton MG, Rose JP, et al. (2002) Towards the crystal structure of glycerol dehydrogenase from Thermotoga maritima. Acta Crystallogr D Biol Crystallogr 58: 867-869. doi:10.1107/S0907444902005012. PubMed: 11976506.
39. Theodorou V, Kimm MA, Boer M, Wessels L, Theelen W, et al. (2007) MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer. Nat Genet 39: 759-769. doi:10.1038/ng2034. PubMed: 17468756.
40. Klauzinska M, Baljinnyam B, Raafat A, Rodriguez-Canales J, Strizzi L, et al. (2011) Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells. J Cell Physiol, 227: 1960-71. PubMed: 21732367.
41. Ranganathan P, Weaver KL, Capobianco AJ, (2011) Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer 11: 338-351. doi:10.1038/nrc3035. PubMed: 21508972.