Chemotherapeutic drugs inhibit ribosome biogenesis at various levels

Journal of Biological Chemistry

Volumn 285, Issue 16, 2010, Pages 12416-12425

  Burger, Kaspar ^a   Mühl, Bastian ^a   Harasim, Thomas ^a   Rohrmoser, Michaela ^a   Malamoussi, Anastassia ^a   Orban, Mathias ^a   Kellner, Markus ^a   Gruber Eber, Anita ^a   Kremmer, Elisabeth ^b   Hölzel, Michael ^a,c   Eick, Dirk ^a  

^a Munich Center for Integrated Protein Science   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5-FLUOROURACIL; CAMPTOTHECINS; CANCER THERAPY; CELLULAR TARGETS; CHEMICAL SUBSTANCE; CHEMOTHERAPEUTIC DRUGS; DOXORUBICIN; DRUG CONCENTRATION; HOMOHARRINGTONINE; IN-VIVO; INHIBITORY CONCENTRATION; MITOXANTRONE; OXALIPLATIN; RIBOSOMAL RNA; RIBOSOME BIOGENESIS; ROSCOVITINE; RRNA PROCESSING; RRNA TRANSCRIPTION; THERAPEUTIC EFFICACY;

BIOLOGICAL RADIATION EFFECTS; DRUG THERAPY; TRANSCRIPTION;

RNA;

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; BUSULFAN; CAMPTOTHECIN; CHLORAMBUCIL; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DACARBAZINE; DACTINOMYCIN; DOXORUBICIN; ETOPOSIDE; FLAVOPIRIDOL; FLUOROURACIL; HOMOHARRINGTONINE; HYDROXYUREA; IRINOTECAN; MELPHALAN; METHOTREXATE; MITOXANTRONE; NIMUSTINE; OXALIPLATIN; PACLITAXEL; RIBOSOME RNA; ROSCOVITINE; THIOTEPA; UNINDEXED DRUG; VINBLASTINE;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG TARGETING; FIBROSARCOMA; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; NUCLEOLUS; PRIORITY JOURNAL; RIBOSOME; RNA PROCESSING; RNA SYNTHESIS; RNA TRANSCRIPTION; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL NUCLEOLUS; DRUG SYNERGISM; FLAVONOIDS; FLUOROURACIL; HUMANS; PIPERIDINES; PROTEIN STABILITY; RIBOSOMES; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, NEOPLASM; RNA, RIBOSOMAL; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77951248778     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.074211     Document Type: Article

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