Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation

Gut

Volumn 48, Issue 5, 2001, Pages 660-666

  Brown, W A ^a   Skinner, S A ^a   Malcontenti Wilson, C ^a   Vogiagis, D ^a   O'Brien, P E ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Apoptosis; Bromodexoyuridine; Chemoprevention; Colorecral cancer; Non steroidal anti inflammatory drugs

Indexed keywords

1,2 DIMETHYLHYDRAZINE; BROXURIDINE; CARCINOGEN; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EOSIN; HEMATOXYLIN; INDOMETACIN; ISOPROTEIN; MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; SULINDAC; SULINDAC SULFONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; HISTOLOGY; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR VOLUME;

ADENOCARCINOMA; ADENOMA; ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; BROMODEOXYURIDINE; CELL DIVISION; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; STAINING AND LABELING;

EID: 0035033709     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.48.5.660     Document Type: Article

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