Non-steroidal anti-inflammatory drug activated gene (NAG-1) expression is closely related to death receptor-4 and -5 induction, which may explain sulindac sulfide induced gastric cancer cell apoptosis

Carcinogenesis

Volumn 25, Issue 10, 2004, Pages 1853-1858

  Jang, Tae Jung ^a   Kang, Hyeock Joo ^a   Kim, Jung Ran ^a   Yang, Chang Heon ^a  

^a Dongguk University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLOOXYGENASE 2; CYTOKINE RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; GENE PRODUCT; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN NAG 1; SULINDAC SULFIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STOMACH CANCER; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CASPASES; CYCLOOXYGENASE INHIBITORS; CYTOKINES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; STOMACH NEOPLASMS; SULINDAC; TUMOR CELLS, CULTURED;

EID: 6444222063     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh199     Document Type: Article

References (43)

1. Kune,G.A., Kune,S. and Watson,L.F. (1988) Colorectal cancer risk, chronic illnesses, operations and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Res., 48, 4399-4404.
2. Coogan,P.F., Rosenberg,L., Palmer,J.R., Strom,B.L., Zauber,A.G., Stolley,P.D. and Shapiro,S. (2000) Nonsteroidal anti-inflammatory drugs and risk of digestive cancers at sites other than the large bowel. Cancer Epidemiol. Biomark Prevent., 9, 119-123.
3. Langman,M.J., Cheng,K.K., Gilman,E.A. and Lancashire,R.J. (2000) Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database. Br. Med. J., 320, 1642-1646.
4. Tsujii,M., Kawano,S., Tsuji,S., Sawaoka,H., Hori,M. and DuBois R.N. (1987) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell, 93, 705-716 (published erratum appears in Cell, 1988, 94, 271).
5. Jones,M.K., Wang,H., Peskar,B.M., Levin,E., Itani,R.M., Sarfeh,I.J. and Tarnawski,A.S. (1999) Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nature Med., 5 1418-1423.
6. Tsujii,M. and DuBois,R. N. (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell, 83, 493-501.
7. Baek,S.J., Kim,K.S., Nixon,J.B., Wilson,L.G. and Eling,T.E. (2001) Cyclooxygenase inhibitors regulate the expression of a TGF-β superfamily member that has proapoptotic and antitumorigenic activities. Mol. Pharmacol., 59, 901-908.
8. Goel,A., Chang,D.K., Ricciardiello,L., Gasche,C. and Boland,C.R. (2003) A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells. Clin. Cancer Res., 9, 383-390.
9. Hanif,R., Pittas,A., Feng,Y., Koutsos,M.I., Qiao,L., Staiano-Coico,L., Shiff,S.I. and Rigas,B. (1996) Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem. Pharmacol., 52, 237-245.
10. Zhang,X., Morham,S.G., Langenbach,R. and Young,D.A. (1999) Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts. J. Exp. Med., 190, 451-459.
11. Kim,K.S., Baek,S.J., Flake,G.P., Loftin,C.D., Calvo,B.F. and Eling,T.E. (2002) Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue. Gastroenterology, 122, 1388-1398.
12. Green,D.R. and Reed,J.C. (1998) Mitochondria and apoptosis. Science, 281, 1309-1312.
13. Ashkenazi,A. and Dixit,V.M. (1999) Apoptosis control by death and decoy receptors. Curr. Opin. Cell Biol., 11, 225-260.
14. Gross,A., McDonnell,J.M. and Korsmeyer,S.J. (2000) BCL-2 family members and the mitochondria in apoptosis. Genes Dev., 13 1899-1911.
15. Zhang,L., Yu,J., Park,B. H., Kinzler,K.W. and Vogelstein,B. (2000) Role of BAX in the apoptotic response to anticancer agents. Science, 290, 989-992.
16. Sun,Y., Tang,X.M., Half,E., Kuo,M.T. and Sinicrope,F.A. (2002) Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res., 62, 6323-6328.
17. Sheridan,J.P, Marsters,S.A., Pitti,R.M. et al. (1997) A control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science, 277, 818-821.
18. Thomas,W.D. and Hersey,P. (1998) TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells. J. Immunol., 161, 2195-2200.
19. Huang,Y., He,Q., Hillman,M.J., Rong,R. and Sheikh,M.S. (2001) Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells. Cancer Res., 61, 6918-6924.
20. Tang,X., Sun,Y.J., Half,E., Kuo,M.T. and Sinicrope,F.A. (2002) Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. Cancer Res., 62, 4903-4908.
21. Song,S.H., Jong,H.S., Choi,H.H., Inoue,H., Tanabe,T., Kim,N.K. and Bang,Y.J. (2001) Transcriptional silencing of cyclooxygenase-2 by hypermethylation of the 5′CpG island in human gastric carcinoma cells. Cancer Res., 61, 4628-4635.
22. Saukkonen,K., Nieminen,O., van Rees,B., Vilkki,S., Harkonen,M., Juhola,M., Mecklin,J.P., Sipponen,P. and Ristimaki,A. (2001) Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. Clin. Cancer Res., 7, 1923-1931.
23. Husain,S.S., Szabo,I.L., Pai,R., Soreghan,B., Jones,M.K. and Tarnawski,A.S. (2001) MAPK (ERK2) kinase - a key target for NSAIDs-induced inhibition of gastric cancer cell proliferation and growth. Life Sci., 69, 3045-3054.
24. Zhu,G.H., Wong,B.C., Eggo,M.C., Ching,C.K., Yuen,S.T., Chan,E.Y., Lai,K.C. and Lam,S.K. (1999) Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. Br. J. Cancer, 79, 393-400.
25. Rigas,B. and Schiff,S.J. (2000) Is inhibition of cyclooxygenase required for the chemopreventive effect of NSAIDs in colon cancer? A model reconciling the current contradiction. Med. Hypoth. 54, 210-215.
26. Shen,T.Y. and Winter,C.A. (1997) Chemical and biological studies on indomethacin, sulindac and analogs. Adv. Drug Res., 12, 90-245.
27. Piazza,G.A., Rahm,A.L., Krutzsch,M., Sperl,G., Paranka,N.S, Gross,P.H., Brendel,K., Burt,R.W., Alberts,D.S. and Pamukcu,R. (1995) Antineoplastic drug sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. Cancer Res., 55, 3110-3116.
28. Piazza,G.A., Alberts,D.S., Hixson,L.J. et al. (1997) Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. Cancer Res., 57, 2909-2915.
29. Qiao,L., Shiff,S.J. and Rigas,B. (1997) Sulindac sulfide induces several subpopulations of colon cancer cells, defined by PCNA/Ki-67 and DNA strand breaks. Biochim. Biophys. Acta Mol. Cell Res., 1359, 222-232.
30. Hanif,R., Pittas,A., Feng,Y., Koutsos,M.I., Qiao,L., Staiano-Coico,L., Shiff,S.I. and Rigas,B. (1996) Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem. Pharmacol., 52, 237-245.
31. Hromas,R., Hufford,M., Sutton,J., Xu,D., Li,Y. and Lu,L. (1997) PLAB, a novel placental bone morphogenetic protein. Biochim. Biophys. Acta, 1354, 40-44.
32. Lawton,L.N., Bonaldo,M.F., Jelenc,P.C. et al. (1997) Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta. Gene, 203, 17-26.
33. Paralkar,V.M., Vail,A.L., Grasser,W.A., Brown,T.A., Xu,H., Vukicevic,S., Ke,H.Z., Qi,H., Owen,T.A. and Thompson,D.D. (1998) Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. J. Biol. Chem., 273, 13760-13767.
34. Bootcov,M.R., Bauskin,A.R., Valenzuela,S.M. et al. (1997) MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc. Natl Acad. Sci. USA, 94, 11514-11519.
35. Whitman,M. (1998) Smads and early developmental signaling by the TGF beta superfamily. Genes Dev., 12, 2445-2462.
36. Wu,G.S., Burns,T.F., McDonald,E.R.,III et al. (1997) KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nature Genet., 17, 141-143.
37. Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M. (1997) An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science, 277, 815-818.
38. MacFarlane,M., Ahmad,M., Srinivasula,S.M., Fernandes-Alnemri,T., Cohen,G.M. and Alnemri,E.S. (1997) Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem., 272, 25417-25420.
39. Lee,D.H., Yang,Y., Lee,S.J. et al. (2003) Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. Cancer Res., 63, 4648-4655.
40. Welsh,J.B., Sapinoso,L.M., Su,A.I., Kern,S.G., Wang-Rodriguez,J., Moskaluk,C.A., Frierson,H..F,Jr and Hampton,G.M. (2001) Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res., 61, 5974-5978.
41. Karan,D., Kelly,D.L., Rizzino,A., Lin,M.F. and Batra,S.K. (2002) Expression profile of differentially regulated genes during progression of androgen-independent growth in human prostate cancer cells. Carcinogenesis, 23, 967-976.
42. Buckhaults,P., Rago,C., St Croix,B., Romans,K.E, Saha,S., Zhang,L., Vogelstein,B. and Kinzler,K.W. (2001) Secreted and cell surface genes expressed in benign and malignant colorectal tumors. Cancer Res. 61, 6996-7001.
43. Wakefield,L.M. and Roberts,A.B. (2002) TGF-beta signaling: positive and negative effects on tumorigenesis. Curr. Opin. Genet. Dev., 12, 22-29.