Wedelolactone inhibits LPS-induced pro-inflammation via NF-kappaB Pathway in RAW 264.7 cells

Journal of Biomedical Science

Volumn 20, Issue 1, 2013, Pages

  Yuan, Fang ^a   Chen, Jie ^b   Sun, Ping Ping ^b   Guan, Su ^c   Xu, Jing ^d  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^d THE THIRD AFFILIATED HOSPITAL OF SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Inflammation; Macrophage; Nuclear factor B (NF B); Popolysaccharide (LPS); Wedelolactone (WEL)

Indexed keywords

AUTACOID; CYCLOOXYGENASE 2; I KAPPA B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; NITRIC OXIDE; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; WEDELOLACTONE; ANTIINFLAMMATORY AGENT; COUMARIN DERIVATIVE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; RELA PROTEIN, MOUSE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; CELL LINE; DOSE RESPONSE; GENETICS; METABOLISM; SIGNAL TRANSDUCTION;

WEDELIA CHINENSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELL LINE; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 84886745311     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-20-84     Document Type: Article

References (29)

1. Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells. Lim S, Jang HJ, Park EH, Kim JK, Kim JM, Kim EK, et al. J Cell Biochem 2012 113 3436 3445 10.1002/jcb.24220 22678810
2. Neutralization of lethal and myotoxic activities of South American rattlesnake venom by extracts and constituents of the plant Eclipta prostrata (Asteraceae). Mors WB, do NMC, Parente JP, da SMH, Melo PA, Suarez-Kurtz G, Toxicon 1989 27 1003 1009 10.1016/0041-0101(89)90151-7 2799833 (Pubitemid 19226954)
3. Inhibition of snake venoms and phospholipases A(2) by extracts from native andgenetically modified Eclipta alba: isolation of active coumestans. Diogo LC, Fernandes RS, Marcussi S, Menaldo DL, Roberto PG, Matrangulo PV, et al. Basic Clin Pharmacol Toxicol 2009 104 293 299 10.1111/j.1742-7843.2008. 00350.x 19320636
4. Pharmacologic inhibitors of IkappaB kinase suppress growth and migration ofmammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis invivo. Idris AI, Libouban H, Nyangoga H, Landao-Bassonga E, Chappard D, Ralston SH, Mol Cancer Ther 2009 8 2339 2347 19671767
5. Herbal extract of Wedelia chinensis attenuates androgen receptor activity andorthotopic growth of prostate cancer in nude mice. Tsai CH, Lin FM, Yang YC, Lee MT, Cha TL, Wu GJ, et al. Clin Cancer Res 2009 15 5435 5444 10.1158/1078-0432.CCR-09-0298 19690196
6. Coumestans as the main active principles of the liver drugs Eclipta alba andWedelia calendulacea. Wagner H, Geyer B, Kiso Y, Hikino H, Rao GS, Planta Med 1986 5 370 374 3797500 (Pubitemid 17195170)
7. Compounds from Wedelia chinensis synergistically suppress androgen activity andgrowth in prostate cancer cells. Lin FM, Chen LR, Lin EH, Ke FC, Chen HY, Tsai MJ, et al. Carcinogenesis 2007 28 2521 2529 10.1093/carcin/bgm137 17942463 (Pubitemid 350238954)
8. HIV-1 protease and HIV-1 integrase inhibitory substances from Eclipta prostrata. Tewtrakul S, Subhadhirasakul S, Cheenpracha S, Karalai C, Phytother Res 2007 21 1092 1095 10.1002/ptr.2252 17696192 (Pubitemid 350190308)
9. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibitingthe IKK complex. Kobori M, Yang Z, Gong D, Heissmeyer V, Zhu H, Jung YK, et al. Cell Death Differ 2004 11 123 130 10.1038/sj.cdd.4401325 14526390 (Pubitemid 38111379)
10. Leishmania promastigotes activate PI3K/Akt signalling to confer host cellresistance to apoptosis. Ruhland A, Leal N, Kima PE, Cell Microbiol 2007 9 84 96 10.1111/j.1462-5822.2006.00769.x 16889626 (Pubitemid 44896837)
11. Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. Syed SD, Deepak M, Yogisha S, Chandrashekar AP, Muddarachappa KA, D'Souza P, et al. Phytother Res 2003 17 420 421 10.1002/ptr.1153 12722155 (Pubitemid 36565356)
12. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Lawrence T, Willoughby DA, Gilroy DW, Nat Rev Immunol 2002 2 787 795 10.1038/nri915 12360216 (Pubitemid 37328718)
13. Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW 264.7 cells. Tao JY, Zheng GH, Zhao L, Wu JG, Zhang XY, Zhang SL, et al. J Ethnopharmacol 2009 123 97 105 10.1016/j.jep.2009.02.024 19429346
14. Bacterial endotoxin: molecular relationships of structure to activity and function. Rietschel ET, Kirikae T, Schade FU, Mamat U, Schmidt G, Loppnow H, et al. FASEB J 1994 8 217 225 8119492 (Pubitemid 24067145)
15. Automated high-throughput siRNA transfection in raw 264.7 macrophages: a case study for optimization procedure. Carralot JP, Kim TK, Lenseigne B, Boese AS, Sommer P, Genovesio A, et al. J Biomol Screen 2009 14 151 160 10.1177/1087057108328762 19196705
16. Lansoprazole inhibits nitric oxide and prostaglandin E(2) production in murine macrophage RAW 264.7 cells. Nakagawa S, Arai Y, Kishida T, Hiraoka N, Tsuchida S, Inoue H, et al. Inflammation 2012 35 1062 1068 10.1007/s10753-011- 9412-7 22134422
17. MAP kinases in immune responses. Zhang YL, Dong C, Cell Mol Immunol 2005 2 20 27 16212907
18. Toll-like receptors in the induction of the innate immune response. Aderem A, Ulevitch RJ, Nature 2000 406 782 787 10.1038/35021228 10963608
19. ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts. Kefaloyianni E, Gaitanaki C, Beis I, et al. Cell Signal 2006 18 2238 2251 10.1016/j.cellsig.2006.05.004 16806820 (Pubitemid 44740489)
20. Anti-inflammatory effects of dichloromethane fraction from Orostachys japonicus in RAW 264.7 cells: suppression of NF-kappaB activation and MAPK signaling. Lee HS, Ryu DS, Lee GS, Lee DS, et al. J Ethnopharmacol 2012 140 271 276 10.1016/j.jep.2012.01.016 22285522
21. PPARalpha activator fenofibrate modulates angiotensin II-induced inflammatory responses in vascular smooth muscle cells via the TLR4-dependent signaling pathway. Ji YY, Liu JT, Liu N, Wang ZD, Liu CH, et al. Biochem Pharmacol 2009 78 1186 1197 10.1016/j.bcp.2009.06.095 19576184
22. Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism. An H, Xu H, Zhang M, Zhou J, Feng T, Qian C, et al. Blood 2005 105 4685 4692 10.1182/blood-2005-01-0191 15701712 (Pubitemid 40807290)
23. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Lee AK, Sung SH, Kim YC, Kim SG, Br J Pharmacol 2003 139 11 20 10.1038/sj.bjp.0705231 12746218 (Pubitemid 36645303)
24. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. Barnes PJ, Karin M, N Engl J Med 1997 336 1066 1071 10.1056/NEJM199704103361506 9091804 (Pubitemid 27163860)
25. LPS induction of gene expression in human monocytes. Guha M, Mackman N, Cell Signal 2001 13 85 94 10.1016/S0898-6568(00)00149-2 11257452 (Pubitemid 32222977)
26. Oleifolioside A, a New Active Compound, Attenuates LPS-Stimulated iNOS and COX-2 Expression through the Downregulation of NF-kappaB and MAPK Activities in RAW 264.7 Macrophages. Yu HY, Kim KS, Lee YC, Moon HI, Lee JH, et al. Evid Based Complement Alternat Med 2012 2012 637512 22911495
27. Physiological and pathophysiological roles of nitric oxide. Stewart AG, Phan LH, Grigoriadis G, et al. Microsurgery 1994 15 693 702 10.1002/micr. 1920151006 7533876
28. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. Wang Z, Jiang W, Zhang Z, Qian M, Du B, J Ethnopharmacol 2012 144 1 145 150 10.1016/j.jep.2012.08.041 22971898
29. Cucurbitacin E exhibits anti-inflammatory effect in RAW 264.7 cells via suppression of NF-kappaB nuclear translocation. Qiao J, Xu LH, He J, Ouyang DY, He XH, Inflamm Res 2013 62 5 461 469 10.1007/s00011-013-0598-z 23360962