Oleifolioside A, a new active compound, attenuates LPS-stimulated iNOS and COX-2 expression through the downregulation of NF-κ B and MAPK Activities in RAW 264.7 Macrophages

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Yu, Hai Yang ^a   Kim, Kyoung Sook ^a   Lee, Young Choon ^a   Moon, Hyung In ^a   Lee, Jai Heon ^a  

^a Dong A University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; OLEIFOLIOSIDE A; PROSTAGLANDIN E; TRANSCRIPTION FACTOR RELA; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN; DNA BINDING; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 84864922730     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/637512     Document Type: Article

References (30)

1. Bae K. H., The Medicinal Plants of Korea 2000 Seoul, Korea Kyo-Hak Publishing
2. Park B. Y., Min B. S., Oh S. R., Kim J. H., Kim T. J., Kim D. H., Bae K. H., Lee H. K., Isolation and anticomplement activity of compounds from Dendropanax morbifera Journal of Ethnopharmacology 2004 90 2-3 403 408
3. Chung I. M., Song H. K., Kim S. J., Moon H. I., Anticomplement activity of polyacetylenes from leaves of Dendropanax morbifera Leveille Phytotherapy Research 2011 25 5 784 786
4. Chung I. M., Kim M. Y., Park W. H., Moon H. I., Antiatherogenic activity of Dendropanax morbifera essential oil in rats Pharmazie 2009 64 8 547 549
5. Chung I. M., Kim M. Y., Park S. D., Park W. H., Moon H. I., In vitro evaluation of the antiplasmodial activity of Dendropanax morbifera against chloroquine-sensitive strains of Plasmodium falciparum Phytotherapy Research 2009 23 11 1634 1637
6. Moon H. I., Antidiabetic effects of dendropanoxide from leaves of Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats Human and Experimental Toxicology 2011 30 8 870 875
7. zipek M., Dnmez A. A., ali I., Brun R., Redi P., Tasdemir D., Leishmanicidal cycloartane-type triterpene glycosides from Astragalus oleifolius Phytochemistry 2005 66 10 1168 1173 (Pubitemid 40728313)
8. Rietschel E. T., Kirikae T., Schade F. U., Mamat U., Schmidt G., Loppnow H., Ulmer A. J., Zahringer U., Seydel U., Di Padova F., Schreier M., Brade H., Bacterial endotoxin: molecular relationships of structure to activity and function FASEB Journal 1994 8 2 217 225 (Pubitemid 24067145)
9. Gallucci S., Provenzano C., Mazzarelli P., Scuderi F., Bartoccioni E., Myoblasts produce IL-6 in response to inflammatory stimuli International Immunology 1998 10 3 267 273 (Pubitemid 28132712)
10. Nakagawa S., Arai Y., Kishida T., Lansoprazole inhibits nitric oxide and prostaglandin E 2 production in murine macrophage RAW 264.7 cells Inflammation 2012 35 3 1062 1068
11. MacMicking J., Xie Q. W., Nathan C., Nitric oxide and macrophage function Annual Review of Immunology 1997 15 323 350 (Pubitemid 27169284)
12. Isomki P., Punnonen J., Pro- and anti-inflammatory cytokines in rheumatoid arthritis Annals of Medicine 1997 29 6 499 507 (Pubitemid 28135102)
13. Shaw P. J., McDermott M. F., Kanneganti T. D., Inflammasomes and autoimmunity Trends in Molecular Medicine 2011 17 2 57 64
14. Alirezaei M., Kemball C. C., Whitton J. L., Autophagy, inflammation and neurodegenerative disease European Journal of Neuroscience 2011 33 2 197 204
15. Arias J. I., Aller M. A., Snchez-Patan F., Arias J., Inflammation and cancer: is trophism the link? Surgical Oncology 2006 15 4 235 242 (Pubitemid 46771197)
16. Jung W. K., Lee D. Y., Park C., Choi Y. H., Choi I., Park S. G., Seo S. K., Lee S. W., Yea S. S., Ahn S. C., Lee C. M., Park W. S., Ko J. H., Choi I. W., Cilostazol is anti-inflammatory in BV2 microglial cells by inactivating nuclear factor-kappaB and inhibiting mitogen-activated protein kinases British Journal of Pharmacology 2010 159 6 1274 1285
17. Moon D. O., Park S. Y., Lee K. J., Heo M. S., Kim K. C., Kim M. O., Lee J. D., Choi Y. H., Kim G. Y., Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia International Immunopharmacology 2007 7 8 1092 1101 (Pubitemid 46900911)
18. Kang J. L., Lee K., Castranova V., Nitric oxide up-regulates DNA-binding activity of nuclear factor- B in macrophages stimulated with silica and inflammatory stimulants Molecular and Cellular Biochemistry 2000 215 1-2 1 9 (Pubitemid 32094937)
19. Honda K., Interleukin-6 and soluble interleukin-6 receptor suppress osteoclastic differentiation by inducing PGE 2 production in chondrocytes Journal of Oral Science 2011 53 1 87 96
20. Baeuerle P. A., Baltimore D., Nf- B: ten years after Cell 1996 87 1 13 20
21. Coulter J. A., McCarthy H. O., Xiang J., Roedl W., Wagner E., Robson T., Hirst D. G., Nitric oxide-A novel therapeutic for cancer Nitric Oxide 2008 19 2 192 198
22. Dawson V. L., Dawson T. M., Nitric oxide in neurodegeneration Progress in Brain Research 1998 118 215 229 (Pubitemid 28530669)
23. Stewart A. G., Phan L. H., Grigoriadis G., Physiological and pathophysiological roles of nitric oxide Microsurgery 1994 15 10 693 702
24. Zamora R., Vodovotz Y., Billiar T. R., Inducible nitric oxide synthase and inflammatory diseases Molecular Medicine 2000 6 5 347 373
25. Kundu J. K., Shin Y. K., Surh Y. J., Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF- B and AP-1 as prime targets Biochemical Pharmacology 2006 72 11 1506 1515 (Pubitemid 44666749)
26. Surh Y. J., Chun K. S., Cha H. H., Han S. S., Keum Y. S., Park K. K., Lee S. S., Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF- B activation Mutation Research 2001 480-481 243 268 (Pubitemid 32744832)
27. Karin M., The beginning of the end: I B kinase (IKK) and NF- B activation Journal of Biological Chemistry 1999 274 39 27339 27342
28. Gilroy D. W., Lawrence T., Perretti M., Rossi A. G., Inflammatory resolution: new opportunities for drug discovery Nature Reviews Drug Discovery 2004 3 5 401 416 (Pubitemid 38618123)
29. Kim J. H., Park Y. M., Shin J. S., Park S. J., Choi J. H., Jung H. J., Park H. J., Lee K. T., Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cells Biological and Pharmaceutical Bulletin 2009 32 6 1062 1068
30. Kim A. R., Lee M. S., Shin T. S., Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF- B, Akt, and p38 MAPK Toxicology in Vitro 2011 25 8 1789 1795