HIV-1 protease and HIV-1 integrase inhibitory substances from Eclipta prostrata

Phytotherapy Research

Volumn 21, Issue 11, 2007, Pages 1092-1095

  Tewtrakul, Supinya ^a   Subhadhirasakul, Sanan ^a   Cheenpracha, Sarot ^a   Karalai, Chatchanok ^a  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

Eclipta prostrata; HIV 1 integrase; HIV 1 protease; Inhibitory activities

Indexed keywords

5 HYDROXYMETHYL (2,2':5',2'') TERTHIENYL ACETATE; 5 HYDROXYMETHYL (2,2':5',2'') TERTHIENYL AGELATE; 5 HYDROXYMETHYL (2,2':5',2'') TERTHIENYL TIGLATE; ACETYL PEPSTATIN; ECLIPTA PROSTRATA EXTRACT; ECLIPTAL; INTEGRASE; OROBOL; PEPSTATIN; PROTEINASE; SURAMIN; UNCLASSIFIED DRUG; WEDELOLACTONE;

ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; ECLIPTA; ECLIPTA PROSTRATA; ENZYME ACTIVITY; FRACTIONATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; NONHUMAN;

ANTI-HIV AGENTS; ECLIPTA; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; PLANT EXTRACTS; PLANTS, MEDICINAL; THAILAND;

ECLIPTA PROSTRATA; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 36549025883     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2252     Document Type: Article

References (16)

1. Cardellina II JH, Bajesh HR, McKee TC, Boyd R. 1995. Resolution and comparative anti-HIV evaluation of the enantiomers of calanolide A and B. Bioorg Med Chem Lett 5: 1011-1014.
2. Das B, Chakravarty AK. 1991. Ecliptal, a new terthienyl aldehyde from Eclipta alba. Indian J Chem B 30: 1052-1053.
3. Han Y, Xia C, Chen X et al. 1998. Preliminary studies on chemical constituents and pharmacological action of Eclipta prostrata L. Zhongguo Zhongyao Zazhi 23: 680-682.
4. Hatano T, Yasuhara T, Miyamoto K, Okuda T. 1988. Anti-human immunodeficiency virus phenolics from Licorice. Chem Pharm Bull 36: 2286-2288.
5. Jain S, Sigh P. 1988. A dithienylacetylene ester from Eclipta erecta Linn. Indian J Chem B 27: 99-100.
6. Jenkins TM, Engelman A, Ghirlando R, Craigie R. 1996. A soluble active mutant of HIV-1 integrase. J Biol Chem 271: 7712-7718.
7. Kobori M, Yang Z, Gong D et al. 2004. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ 11: 123-130.
8. Kosuge T, Ishida H, Satoh T. 1985. Studies on antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. IV. On antihemorrhagic principles in Hypericum erectum Thunb. Chem Pharm Bull 33: 202-205.
9. Liu X, Zhao Y, Jiang, Y, Tang H. 2001. Effect of ethylacetate extract of Eclipta prostrata on function of T-lymphocytes. Disi Junyi Daxue Xuebao 22: 754-756.
10. Sashida Y, Nakata H, Shimomura H, Kagaya M. 1983. Sesquiterpene lactones from pyrethrum flowers. Phytochemistry 22: 1219-1222.
11. Tewtrakul S, Miyashiro H, Hattori M et al. 2001. Inhibitory effects of flavonoids on human immunodeficiency virus type-1 integrase. J Trad Med 18: 229-238.
12. Tewtrakul S, Subhadhirasakul S, Kummee S. 2003. HIV-1 protease inhibitory effects of medicinal plants used as self medication by AIDS patients. Songklanakarin J Sci Technol 25: 239-243.
13. Tewtrakul S., Subhadhirasakul S, Kummee S. 2006. Anti-HIV-1 integrase activity of medicinal plants used as self-medication by AIDS patients. Songklanakarin J Sci Technol. 28: 785-790.
14. Tungtrongjit K. 1978. Pramuan Supphakun Ya Thai. Pisanslip Press: Bangkok, 107-108.
15. Wiart C, Mogana S, Khalifah S et al. 2004. Antimicrobial screening of plants used for traditional medicine in the state of Perak, Penisular Malaysia. Fitoterapia 75: 68-73.
16. Wutthithamavet W. 1997. Thai Traditional Medicine, revised edition. Odean Store Press: Bangkok, 268.