Lysophosphatidic acid-induced membrane ruffling and brain-derived neurotrophic factor gene expression are mediated by ATP release in primary microglia

Journal of Neurochemistry

Volumn 107, Issue 1, 2008, Pages 152-160

  Fujita, Ryousuke ^a   Ma, Yan ^a   Ueda, Hiroshi ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

ATP; Brain derived neurotrophic factor; Lysophosphatidic acid; Membrane ruffling; Microglia

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTISENSE OLIGODEOXYNUCLEOTIDE; APYRASE; BRAIN DERIVED NEUROTROPHIC FACTOR; LUCIFERASE; LUCIFERIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 1; LYSOPHOSPHATIDIC ACID RECEPTOR 2; LYSOPHOSPHATIDIC ACID RECEPTOR 3; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PURINERGIC P2X4 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLUMINESCENCE; CELL ACTIVATION; CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION; MEMBRANE DAMAGE; MICROGLIA; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPE; SIGNAL TRANSDUCTION; UPREGULATION;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURFACE EXTENSIONS; CELLS, CULTURED; GENE EXPRESSION REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; LYSOPHOSPHOLIPIDS; MICROGLIA; MICROSCOPY, ELECTRON, SCANNING; RATS; RATS, WISTAR; RECEPTORS, LYSOPHOSPHATIDIC ACID; RECEPTORS, PURINERGIC P2; RNA, MESSENGER; TYPE C PHOSPHOLIPASES;

RATTUS;

EID: 51849155044     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05599.x     Document Type: Article

References (51)

1. An S., Bleu T., Hallmark O. G. Goetzl E. J. (1998) Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J. Biol. Chem. 273, 7906 7910.
2. Anliker B. Chun J. (2004) Lysophospholipid G protein-coupled receptors. J. Biol. Chem. 279, 20555 20558.
3. Bandoh K., Aoki J., Hosono H., Kobayashi S., Kobayashi T., Murakami-Murofushi K., Tsujimoto M., Arai H. Inoue K. (1999) Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 274, 27776 27785.
4. Chun J. (2005) Lysophospholipids in the nervous system. Prostaglandins Other Lipid Mediat. 77, 46 51.
5. Chun J., Contos J. J. Munroe D. (1999) A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs). Cell Biochem. Biophys. 30, 213 242.
6. Chun J., Goetzl E. J., Hla T., Igarashi Y., Lynch K. R., Moolenaar W., Pyne S. Tigyi G. (2002) International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 54, 265 269.
7. Contos J. J., Ishii I. Chun J. (2000) Lysophosphatidic acid receptors. Mol. Pharmacol. 58, 1188 1196.
8. Coull J. A., Boudreau D., Bachand K., Prescott S. A., Nault F., Sik A., De Koninck P. De Koninck Y. (2003) Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424, 938 942.
9. Coull J. A., Beggs S., Boudreau D., Boivin D., Tsuda M., Inoue K., Gravel C., Salter M. W. De Koninck Y. (2005) BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438, 1017 1021.
10. Fujita R., Kiguchi N. Ueda H. (2007) LPA-mediated demyelination in ex vivo culture of dorsal root. Neurochem. Int. 50, 351 355.
11. Fukushima N. Chun J. (2001) The LPA receptors. Prostaglandins Other Lipid Mediat. 64, 21 32.
12. Fukushima N., Ishii I., Contos J. J., Weiner J. A. Chun J. (2001) Lysophospholipid receptors. Annu. Rev. Pharmacol. Toxicol. 41, 507 534.
13. Goetzl E. J. An S. (1998) Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 12, 1589 1598.
14. Hamabe W., Fujita R. Ueda H. (2003) Neuronal necrosis inhibition by insulin through protein kinase C activation. J. Pharmacol. Exp. Ther. 307, 205 212.
15. Haynes S. E., Hollopeter G., Yang G., Kurpius D., Dailey M. E., Gan W. B. Julius D. (2006) The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat. Neurosci. 9, 1512 1519.
16. Hecht J. H., Weiner J. A., Post S. R. Chun J. (1996) Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol. 135, 1071 1083.
17. Hla T., Lee M. J., Ancellin N., Paik J. H. Kluk M. J. (2001) Lysophospholipids-receptor revelations. Science 294, 1875 1878.
18. Honda S., Sasaki Y., Ohsawa K., Imai Y., Nakamura Y., Inoue K. Kohsaka S. (2001) Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci. 21, 1975 1982.
19. Inoue M., Rashid M. H., Fujita R., Contos J. J., Chun J. Ueda H. (2004) Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat. Med. 10, 712 718.
20. Inoue K., Koizumi S. Tsuda M. (2007) The role of nucleotides in the neuron-glia communication responsible for the brain functions. J. Neurochem. 102, 1447 1458.
21. Ishii I., Fukushima N., Ye X. Chun J. (2004) Lysophospholipid receptors: signaling and biology. Annu. Rev. Biochem. 73, 321 354.
22. Khakh B. S., Burnstock G., Kennedy C., King B. F., North R. A., Seguela P., Voigt M. Humphrey P. P. (2001) International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol. Rev. 53, 107 118.
23. Kobayashi K., Yamanaka H., Fukuoka T., Dai Y., Obata K. Noguchi K. (2008) P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain. J. Neurosci. 28, 2892 2902.
24. Komoszynski M. Wojtczak A. (1996) Apyrases (ATP diphosphohydrolases, EC 3.6.1.5): function and relationship to ATPases. Biochim. Biophys. Acta 1310, 233 241.
25. Lee C. W., Rivera R., Gardell S., Dubin A. E. Chun J. (2006) GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J. Biol. Chem. 281, 23589 23597.
26. Meyer zu Heringdorf D. Jakobs K. H. (2007) Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism. Biochim. Biophys. Acta 1768, 923 940.
27. Moalem G. Tracey D. J. (2006) Immune and inflammatory mechanisms in neuropathic pain. Brain Res. Rev. 51, 240 264.
28. Moller T., Contos J. J., Musante D. B., Chun J. Ransom B. R. (2001) Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells. J. Biol. Chem. 276, 25946 25952.
29. Nagy A., Shuster T. A. Rosenberg M. D. (1983) Adenosine triphosphatase activity at the external surface of chicken brain synaptosomes. J. Neurochem. 40, 226 234.
30. Noguchi K., Ishii S. Shimizu T. (2003) Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J. Biol. Chem. 278, 25600 25606.
31. Obata K. Noguchi K. (2006) BDNF in sensory neurons and chronic pain. Neurosci. Res. 55, 1 10.
32. Ohsawa K., Irino Y., Nakamura Y., Akazawa C., Inoue K. Kohsaka S. (2007) Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. Glia 55, 604 616.
33. Ohta H., Sato K., Murata N. et al. (2003) Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol. Pharmacol. 64, 994 1005.
34. Sardar V. M., Bautista D. L., Fischer D. J., Yokoyama K., Nusser N., Virag T., Wang D. A., Baker D. L., Tigyi G. Parrill A. L. (2002) Molecular basis for lysophosphatidic acid receptor antagonist selectivity. Biochim. Biophys. Acta 1582, 309 317.
35. + channels for lysophosphatidic acid-induced microglial migration. Eur. J. Neurosci. 19, 1469 1474.
36. Sprague R. S., Bowles E. A., Olearczyk J. J., Stephenson A. H. Lonigro A. J. (2002) The role of G protein beta subunits in the release of ATP from human erythrocytes. J. Physiol. Pharmacol. 53, 667 674.
37. Takayama N. Ueda H. (2005) Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia. J. Neurosci. 25, 430 435.
38. Tham C. S., Lin F. F., Rao T. S., Yu N. Webb M. (2003) Microglial activation state and lysophospholipid acid receptor expression. Int. J. Dev. Neurosci. 21, 431 443.
39. Tozaki-Saitoh H., Tsuda M., Miyata H., Ueda K., Kohsaka S. Inoue K. (2008) P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury. J. Neurosci. 28, 4949 4956.
40. Trang T., Beggs S. Salter M. W. (2006) Purinoceptors in microglia and neuropathic pain. Pflugers Arch. 452, 645 652.
41. Tsuda M., Shigemoto-Mogami Y., Koizumi S., Mizokoshi A., Kohsaka S., Salter M. W. Inoue K. (2003) P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424, 778 783.
42. Tsuda M., Inoue K. Salter M. W. (2005) Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci. 28, 101 107.
43. Ueda H. (2006) Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms. Pharmacol. Ther. 109, 57 77.
44. Ueda H. (2008) Peripheral mechanisms of neuropathic pain - involvement of lysophosphatidic acid receptor-mediated demyelination. Mol. Pain 4, 11.
45. Ueda H. Inoue M. (2000) In vivo signal transduction of nociceptive response by kyotorphin (tyrosine-arginine) through Galpha(i)- and inositol trisphosphate-mediated Ca(2+) influx. Mol. Pharmacol. 57, 108 115.
46. Virginio C., Robertson G., Surprenant A. North R. A. (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol. Pharmacol. 53, 969 973.
47. Wieseler-Frank J., Maier S. F. Watkins L. R. (2004) Glial activation and pathological pain. Neurochem. Int. 45, 389 395.
48. Ye X., Fukushima N., Kingsbury M. A. Chun J. (2002) Lysophosphatidic acid in neural signaling. Neuroreport 13, 2169 2175.
49. Zhou X. F., Chie E. T., Deng Y. S., Zhong J. H., Xue Q., Rush R. A. Xian C. J. (1999) Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat. Neuroscience 92, 841 853.
50. Zizzo M. G., Mule F. Serio R. (2007a) Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon. Br. J. Pharmacol. 151, 73 81.
51. Zizzo M. G., Mule F. Serio R. (2007b) Inhibitory purinergic transmission in mouse caecum: role for P2Y1 receptors as prejunctional modulators of ATP release. Neuroscience 150, 658 664.