Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice

PLoS ONE

Volumn 5, Issue 3, 2010, Pages

  Gengler, Simon ^a   Hamilton, Alison ^a   Hölscher, Christian ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL; ARTICLE; C57BL MOUSE; DISEASE MODEL; FEMALE; GENETICS; GENOTYPE; HETEROZYGOTE; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; METABOLISM; MOUSE; NERVE CELL PLASTICITY; PHYSIOLOGY; SYNAPSE; SYNAPTIC TRANSMISSION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GENOTYPE; HETEROZYGOTE; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MICE; MICE, INBRED C57BL; NEURONAL PLASTICITY; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 79151475030     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009764     Document Type: Article

References (34)

1. Alzheimer A (1907) Ueber eine eigenartige Erkrankung der Hirnrinde. Zeitschrift fuer Psychiatrie 64: 146-149.
2. Holscher C (2005) Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies. Rev Neurosci 16: 181-212.
3. Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, et al. (2006) Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep 7: 940-946.
4. Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, et al. (2002) Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proc Natl Acad Sci U S A 99: 8025-8030.
5. Bliss TVP, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361: 31-39.
6. Hölscher C, ed (2001) Long-term potentiation induced by stimulation on the positive phase of theta rhythm: a better model for learning and memory? Cambridge: Cambridge University Press. pp 146-167.
7. Roder S, Danober L, Pozza MF, Lingenhoehl K, Wiederhold KH, et al. (2003) Electrophysiological studies on the hippocampus and prefrontal cortex assessing the effects of amyloidosis in amyloid precursor protein 23 transgenic mice. Neuroscience 120: 705-720.
8. Chapman P, White G, Jones M, Cooper-Blacketer D, Marshall V, et al. (1999) Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 3: 271-276.
9. Gureviciene I, Ikonen S, Gurevicius K, Sarkaki A, van Groen T, et al. (2004) Normal induction but accelerated decay of LTP in APP + PS1 transgenic mice. Neurobiol Dis 15: 188-195.
10. Volianskis A, Kostner R, Molgaard M, Hass S, Jensen MS (2008) Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1DeltaE9-deleted transgenic mice model of beta-amyloidosis. Neurobiol Aging. Epub ahead of print.
11. Chen Y, Chad JE, Wheal HV (1996) Synaptic release rather than failure in the conditioning pulse results in paired-pulse facilitation during minimal synaptic stimulation in the rat hippocampal CA1 neurones. Neurosci Lett 218: 204-208.
12. Schulz PE, Cook EP, Johnston D (1995) Using paired-pulse facilitation to probe the mechanisms for long-term potentiation. J Physiol (Paris) 89: 3-9.
13. Tsai ML, Shen B, Leung LS (2008) Seizures induced by GABAB-receptor blockade in early-life induced long-term GABA(B) receptor hypofunction and kindling facilitation. Epilepsy Res 79: 187-200.
14. Long JM, Kalehua AN, Muth NJ, Calhoun ME, Jucker M, et al. (1998) Stereological analysis of astrocyte and microglia in aging mouse hippocampus. Neurobiol Aging 19: 497-503.
15. Bondolfi L, Calhoun M, Ermini F, Kuhn HG, Wiederhold KH, et al. (2002) Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice. J Neurosci 22: 515-522.
16. Cummings BJ, Mason AJ, Kim RC, Sheu PC, Anderson AJ (2002) Optimization of techniques for the maximal detection and quantification of Alzheimer'srelated neuropathology with digital imaging. Neurobiol Aging 23: 161-170.
17. Dema A, Tudose N (1998) Immunohistochemical expression of prostate specific antigen (PSA) in benign and malignant tumors of the prostate. Rom J Morphol Embryol 44: 93-100.
18. Wilcox R (2005) The Yuen-Welch Test. In: Wilcox R, ed. Introduction To Robust Estimation and Hypothesis Testing: Elsevier Academic Press.
19. Yuen K (1974) The two-sample trimmed t for unequal population variances. Biometrika 61: 165-170.
20. Priller C, Mitteregger G, Paluch S, Vassallo N, Staufenbiel M, et al. (2009) Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice. Neurobiol Aging 30: 1227-1237.
21. Kalaria RN, Cohen DL, Premkumar D (1996) Cellular aspects of the inflammatory response in Alzheimer's disease. Neurodegeneration 5: 497-503.
22. Larson J, Lynch G, Games D, Seubert P (1999) Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice. Brain Res 840: 23-35.
23. Sturchler-Pierrat C, Staufenbiel M (2000) Pathogenic Mechanisms of Alzheimer's Disease Analyzed in the APP23 Transgenic Mouse Model. Annals of the New York Academy of Sciences. New York: NYAS. pp 134-139.
24. Ashe KH (2005) Mechanisms of memory loss in Abeta and tau mouse models. Biochem Soc Trans. pp 591-594.
25. Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, et al. (2007) Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem 282: 23818-23828.
26. Palop JJ, Mucke L (2009) Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol 66: 435-440.
27. Rao SC, Dove G, Cascino GD, Petersen RC (2009) Recurrent seizures in patients with dementia: frequency, seizure types, and treatment outcome. Epilepsy Behav 14: 118-120.
28. Wiley CA, Lopresti BJ, Venneti S, Price J, Klunk WE, et al. (2009) Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Arch Neurol 66: 60-67.
29. Wang Y, Greig NH, Yu QS, Mattson MP (2009) Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices. Neurobiol Aging 30: 1061-1068.
30. Dewachter I, Reverse D, Caluwaerts N, Ris L, Kuiperi C, et al. (2002) Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. J Neurosci 22: 3445-3453.
31. Dewachter I, Ris L, Croes S, Borghgraef P, Devijver H, et al. (2008) Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1. Neurobiol Aging 29: 639-652.
32. Yoshiike Y, Kimura T, Yamashita S, Furudate H, Mizoroki T, et al. (2008) GABA(A) receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin. PLoS ONE 3: e3029.
33. Tsai ML, Leung LS (2006) Decrease of hippocampal GABA B receptormediated inhibition after hyperthermia-induced seizures in immature rats. Epilepsia 47: 277-287.
34. Del Vecchio RA, Gold LH, Novick SJ, Wong G, Hyde LA (2004) Increased seizure threshold and severity in young transgenic CRND8 mice. Neurosci Lett 367: 164-167.