Evidence for phenylalanine zipper-mediated dimerization in the X-ray crystal structure of a magainin 2 analogue

Journal of the American Chemical Society

Volumn 135, Issue 42, 2013, Pages 15738-15741

  Hayouka, Zvi ^a   Mortenson, David E ^a   Kreitler, Dale F ^a   Weisblum, Bernard ^b   Forest, Katrina T ^a   Gellman, Samuel H ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DIMERIZATION; NETWORK SECURITY; PEPTIDES;

ANTI-BACTERIAL ACTIVITY; FOLDING PROPENSITIES; HIGH-RESOLUTION STRUCTURES; HOST DEFENSE; LARGE GROUPS; MAGAININ; NATURAL PEPTIDE; X RAY CRYSTAL STRUCTURES;

CRYSTAL STRUCTURE;

MAGAININ 2; PEXIGANAN; PHENYLALANINE; ANTIINFECTIVE AGENT; MAGAININ 2 PEPTIDE, XENOPUS; MAGAININ DERIVATIVE; XENOPUS PROTEIN;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RACEMIZATION; STAPHYLOCOCCUS AUREUS; STEREOCHEMISTRY; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; MAGAININS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PHENYLALANINE; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS PROTEINS;

EID: 84886532206     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja409082w     Document Type: Article

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